The Biological and Pharmacological Role of Nitric Oxide in Platelet Function (original) (raw)

References

• Barrett, M.L., Willis, A.L. and Vane, J.R., 1989, Inhibition of platelet-derived mitogen release by nitric oxide (EDRF), Agents and Actions 27:488.
  Article PubMed CAS Google Scholar
• Basista, M., Grodzinska, L. and Swies, J., 1985, The influence of molsidomine and its active metabolite SIN-1 on fibrinolysis and platelet aggregation, Thromb. Haemost. 54:746.
  PubMed CAS Google Scholar
• Baydoun, A.R., Emery, P.W., Pearson, J.D. and Mann, G.E., 1990, Substrate-dependent regulation of intracellular amino acid concentrations in cultured bovine aortic endothelial cells, Biochem. Biophys. Res. Commun. 173:940.
  Article PubMed CAS Google Scholar
• Beckman, J.S., Beckman, T.W., Chen, J., Marshall, P.A. and Freeman, B.A., 1990, Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide, Proc. Natl. Acad. Sci. USA 87:1620.
  Article PubMed CAS Google Scholar
• Bhardwaj, R., Page, C.P., May, G.R. and Moore, P.K., 1988, Endothelium-derived relaxing factor inhibits platelet aggregation in human whole blood in vitro and in the rat in vivo, Eur. J. Pharmacol. 157:83.
  Article PubMed CAS Google Scholar
• Brune, B. and Ullrich, V., 1991, 12-hydroperoxyeicosatetгaenoic acid inhibits main platelet functions by activation of soluble guanylate cyclase, Mol. Pharmacol. 39:671.
  PubMed CAS Google Scholar
• Buchanan, M.R., Richardson, M., Haas, T.A., Hirsh, J. and Madri, J.A., 1987, The basement membrane underlying the vascular endothelium is not thrombogenic: In vivo and in vitro studies with rabbit and human tissue, Thromb. Haemost. 58:698.
  PubMed CAS Google Scholar
• Caren, R. and Corbo, L., 1973, Response of plasma lipids and platelet aggregation to intravenous argimne, Proc. Soc. Exp. Biol. Med. 143:1067.
  PubMed CAS Google Scholar
• Chester, A.H., O’Neil, G.S., Moncada, S., Tadjkarimi, S. and Yacoub, M.H., 1990, Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries, Lancet 336:897.
  Article PubMed CAS Google Scholar
• Corrigan, J.J., Jr., Ray, W. and May, N., 1968, Changes in the blood coagulation system associated with septicemia, New Engl. J. Med. 279:851.
  Article PubMed Google Scholar
• Davies, T., Davidson, M.M.L., Mc Clenaghan, M.D, Say, A. and Haslam, R.J., 1976, Factors affecting platelet cyclic GMP levels during aggregation induced by collagen and by arachidonic acid. Thromb. Res. 9:387.
  Article PubMed CAS Google Scholar
• Drexler, H., Zeiher, A.M., Wollschlager, H., Meinertz, T., Just, H. and Bonzel, T., 1989, Flow-dependent coronary artery dilatation in humans, Circulation 80:466.
  Article PubMed CAS Google Scholar
• Durante, W., Schini, V.B., Scott-Burden, T., Junquero, D.C., Kroll, M.H., Vanhoutte, P.M. and Schafer, A.I., 1991, Platelet inhibition by an L- arginine-derived substance released by I1-lß-treated vascular smooth muscle cells, Am. J. Physiol. 261:H2024
  PubMed CAS Google Scholar
• Feelisch, M. and Noack, E.A., 1987, Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase, Eur. J. Pharmacol. 139:19.
  Article PubMed CAS Google Scholar
• Furchgott, R.F., 1988, Studies on relaxation of rabbit aorta by sodium nitrite: the basis for the proposal that the acid-activatab a inhibitory factor from retractor penis is inorganic nitrite and the endothelium-derived relaxing factor is nitric oxide, in: “Vasodilatation: Vascular Smooth muscle, Peptides,Autonomic Nerves and Endothelium”. P.M. Vanhoutte, ed., Raven Press, New York.
  Google Scholar
• Furchgott, R.F., Zawadzki. and J.V., 1980, The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature 288:373.
  Article PubMed CAS Google Scholar
• Fuster, V., Badimon, L., Badimon, J., Adams, P.C., Turitto, V. and Chesebro, J.H., 1987, Drugs interfering with platelet functions: mechanisms and clinical relevance, in: Thrombosis and Haemostasis 1987 eds. Verstraete, M., Vermylen, J., Lijnen, R., Arnout, J., University Press, Leuven.
  Google Scholar
• Gasic, G.J. and Gasic, T.B., 1962, Removal of sialic acid from the cell coat in tumor cells and vascular endothelium, and its effect on metastasis, Proc. Natl. Acad. Sci. USA 48:1172.
  Article PubMed CAS Google Scholar
• Gasic, G.J., Gasic, T.B., Galanti, N., Johnson, T. and Murphy, S., 1973, Platelet-tumor cell interactions in mice. The role of platelets in the spread of malignant disease, 1nt. J. Cancer 11:704.
  Article CAS Google Scholar
• Gebalska, J., 1990, Platelet adhesion and aggregation in relation to clinical course of acute myocardial infarction, M.D. thesis, Warsaw (in Polish).
  Google Scholar
• Goldberg, N.D., Haddox, M.K., Nicol, S.E., Glass, D.B, Sanford, C.H., Kuehl, Jr., F.A. and Estensen, R., 1975, Biological regulation through opposing influences of cyclic GMP and cyclic AMP: The yin yang hypothesis, in: Advances in Cyclic Nucleotide Research vol.5., Drummond, G.I., Greengard, P., Robison, G.A., eds. Raven Press, New York
  Google Scholar
• Gordge, M.P. and Neild, G.H., 1992, Impaired activity of soluble guanylate cyclase in platelets from haemodialysis patients, Br.J.Haematol. 8051:7
  Google Scholar
• Grant, P.G. and Colman, R.W., 1984, Purification and characterization of a human platelet cyclic nucleotide phosphodiesterase, Biochemistry 23:1801.
  Article PubMed CAS Google Scholar
• Grant, P.G., Mannarino, A.F and Colman, R.W., 1990, Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from the cytosol of human platelets. _Thromb. Res._59:105.
  Article PubMed CAS Google Scholar
• Gryglewski, R.J., Palmer, R.M.J. and Monada, S., 1986, Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor, Nature 320:454.
  Article PubMed CAS Google Scholar
• Herbaczynska-Cedro, K., Lembowich, K. and Pytel, B., 1991, NG-monomethyl-L-arginine increases platelet deposition on damaged endothelium in vivo. A scanning electron microscopy study, Thromb. Res. 64:1.
  Article PubMed CAS Google Scholar
• Hibbs, J.B., Jr., Taintor, R.R., Vavrin, Z., Granger, D.L., Drapier, J.C., Amber, I,J. and Lancaster, J.R., Jr., 1990, Synthesis of nitric oxide from a terminal guanidino atom of L- arginine: a molecular mechanism regulating cellular proliferation that targets intracellular iron, in: Nitric oxide from L-Arginine: A Bioregulatory System, ed. Monada, S., Higgs, E.A., Elsevier, Amsterdam.
  Google Scholar
• Hidaka, H. and Asano, T., 1976, Human blood platelet 3’:5’-cyclic nucleotide phosphodiesterase. Biochim. Biophys. Acta 429:485.
  Article PubMed CAS Google Scholar
• Hogan, J.C., Lewis, M.J. and Henderson, A.H., 1988, In vivo EDRF activity influences platelet function, Br. J. Pharmacol. 94:1020.
  Article PubMed CAS Google Scholar
• Houston, D.S., Gerrard, J.M., NcCrea, J., Glover, S. and Butler, A.M., 1983, The influence of amines on various platelet responses, Biochim. Biophys. Acta 734:267.
  Article PubMed CAS Google Scholar
• Houston, D.S., Robinson, P. and Gerrard, J.M., 1990, Inhibition of intravascular platelet aggregation by endothelium-derived relaxing factor: reversal by red blood cells, Blood 76:953.
  PubMed CAS Google Scholar
• Humphries, R.G., Tomlinson, W., O’Connor, S.E. and Leff, P., 1990, Inhibition of collagen-and ADP-induced platelet aggregation by substance P in vivo: Involvement of endothelium-derived relaxing factor, J. Cardiovasc. Pharmacol. 16:292.
  Article PubMed CAS Google Scholar
• Ignarro, L.J., Byrns, R.E. and Wood, K.S., 1988, Biochemical and pharmacological properties of endothelium-derived relaxing factor and its similarity to nitric oxide radical, in: “Vasodilatation:Vascular Smooth muscle, Peptides, Autonomic Nerves and Endothelium ”. P.M. Vanhoutte, ed., Raven Press, New York.
  Google Scholar
• Iuliano, L., Pratico, D., Ghiselli, A., Bonavita, M.S. and Violi, F., 1991, Superoxide dismutase triggers activation of “primed” platelets, Arch. Biochim. Biophys. 289:180.
  Article CAS Google Scholar
• Jandak, J., Steiner, M. and Richardson, P.D., 1989, Alpha-tocopherol, an effective inhibitor of platelet adhesion, Blood 73:141.
  PubMed CAS Google Scholar
• Jansen, W., Prenze, R., Kumper, H. and Tauchert, M., 1990, Interval treatment of coronary artery disease with sustained-release isosorbide-5-mononitrate, Am. J. Cardiol. 65:16J.
  Article PubMed CAS Google Scholar
• Korbut, R., Lidbury, P.S. and Vane, J.R., 1991, Prolongation of fibrinolytic activity of tissue plasminogen activator by nitrovasodilators, Lancet 335:669.
  Article Google Scholar
• Lang, D. and Lewis, M.J., 1991, Inhibition of inositol 1,4,5-triphosphate formation by cyclic GMP in cultured aortic endothelial cells of the pig, Br. J. Pharmacol. 102:277.
  Article PubMed CAS Google Scholar
• Lansman, J.B., Hallam, T.J. and Rink, T.J., 1987, Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers? Nature 325:811.
  Article PubMed CAS Google Scholar
• Laustiola, K.E., Vuorinen, P., Porsti, I., Metsa-Ketela, T. and Vapaatalo, H., 1991, Exogenous GTP enhances the effects of sodium nitrite on cyclic GMP accumulation, vascular smooth muscle relaxation and platelet aggregation, Pharmacol. Toxicol. 68:60.
  Article PubMed CAS Google Scholar
• Lelchuk, R., Radomski, M.W., Martin, J.F. and Moncada, S., 1992, Constitutive and inducible nitric oxide synthases in human megakaryoblastic cells., J. Pharmacol. Exp. Ther., 262; 1220.
  PubMed CAS Google Scholar
• Loscalzo, J. and Vaughan, D.E., 1987, Tissue Plasminogen activator promotes platelet disaggregation in plasma, J. Clin. Invest. 79:1749.
  Article PubMed CAS Google Scholar
• Luscher, T.F., Yang, Z., Diederich, D. and Buhler, F.R., 1989, Endothelium-derived vasoactive substances: Potential role in hypertension, atherosclerosis, and vascular occlusion, J. Cardiovasc. Pharmacol. 14:563.
  Google Scholar
• Marcus, A.J. and Zucker, M.B., 1965, The physiology of blood platelets, Grune & Stratton Inc. New York, London.
  Google Scholar
• Martin, W., Villani, G.M., Jothianandan, D. and Furchgott, R. F., 1985, Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta, J. Pharmacol. Exp. Ther. 232:708.
  PubMed CAS Google Scholar
• Martin, W., White, D.G. and Henderson, A.H., 1988, Endothelium-derived relaxing factor and atriopeptin II elevate cyclic GMP levels in pig aortic endothelial cells. Br. J. Pharmacol. 93:229.
  Article PubMed CAS Google Scholar
• Matsuoka, I., Nakahata, N. and Nakanishi, H., 1989, Inhibitory effect of 8-bromo cyclic GMP on an extracellular Ca2+ -dependent arachidonic acid liberation in collagen -stimulated rabbit platelets, Biochem. Pharmacol. 38:1841.
  Article PubMed CAS Google Scholar
• Maurice, D.H. and Haslam, R.J., 1990, Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: Inhibition of cyclic AMP breakdown by cyclic GMP, Mol. Pharmacol. 37:671.
  PubMed CAS Google Scholar
• May, G.R., Crook, P., Moore P.K. and Page, C.P., 1991, The role of nitric oxide as an endogenous regulator of platelet and neutrophil activation within the pulmonary circulation of the rabbit, Br. J. Pharmacol. 102:759.
  Article PubMed CAS Google Scholar
• Mellion, B.T., Ignarro,L.J., Ohlstein, E.H., Pontecorvo, E. G., Hyman,A.L. and Kadowitz, P.J., 1981, Evidence for the inhibitory role of guanosine 3’,5’-monophosphate in ADP - induced human platelet aggregation in the presence of nitric oxide and related vasodilators, Blood 57:946.
  PubMed CAS Google Scholar
• Mellion, B.T., Ignarro, L.J., Myers, C.B., Ohlstein, E.H., Ballot, B.A., Hymana, A.L. and Kadowitz, P.J., 1983, Inhibition of human platelet aggregation by S-nitrosothiols. Herne-dependent activation of soluble guanylate cyclase and stimulation of cyclic GMP accumulation, Mol. Pharmacol. 23:653.
  PubMed CAS Google Scholar
• Mills, D.C.B., 1981, The basic biochemistry of the platelet, in: Haemostasis and Thrombosis, ed. Bloom, A.L., Thomas, D.P., Churchill Livingstone, Edinburgh, London, Melbourne, New York.
  Google Scholar
• Molina y Vedia, L., McDonald, B., Brune, B. and Lapetina, E.G., 1992, Nitric oxide-induced 8-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation, Biol. Chem., 267; 24929.
  Google Scholar
• Moncada, S., Gryglewski, R.J., Bunting, S. and Vane, J.R., 1976, An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation, Nature 263:663.
  Article PubMed CAS Google Scholar
• Moncada, S., Palmer, R.M.J. and Higgs, E.A., 1989, Biosynthesis of nitric oxide from L-arginine. Apathway for the regulation of cell function and communication, Biochem. Pharmacol. 38:1709.
  Article PubMed CAS Google Scholar
• Moncada, S., Palmer, R.M.J. and Higgs, E.A., 1991, Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43:109
  PubMed CAS Google Scholar
• Morgan, R.O. and Newby, A.C., 1989, Nitroprusside differentially inhibits ADP-stimulated calcium influx and mobilization in human platelets, Biochem. J. 258:447.
  PubMed CAS Google Scholar
• Murray, R., Shipp, E. and FitzGerald, G.A., 1990, Prostaglandin endoperoxide/thromboxane A2 receptor desensitization. Cross-talk with adenylate cyclase in human platelets. J. Biol. Chem. 265:21670.
  PubMed CAS Google Scholar
• Nakashima, S., Tohmatsu, T., Hattori, H., Okano, Y. and Nozawa, Y., 1986, Inhibitory action of cyclic GMP on secretion, polyphosphoinositide hydrolysis and calcium mobilization in thrombin-stimulated human platelet, Biochem. Biophys. Res. Commun. 135:109.
  Article Google Scholar
• Ohno, M., Ochiai, M., Taguchi, J., Hara, K., Akatsuka, N. and Kurokawa, K., 1990, Stretch may enhance the release of endothelium-derived relaxing factor in rabbit aorta, Biochem. Biophys. Res. Commun.173:1038.
  Article PubMed CAS Google Scholar
• Palmer, R.M.J., Ashton, D.S. and Moncada, S., 1988, Vascular endothelial cells synthesize nitric oxide from L-arginine, Nature 333:664.
  Article PubMed CAS Google Scholar
• Palmer, R.M.J., Bridge, L., Foxwell, N.A. and Moncada, S., 1992, The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids, Br. J. Pharmacol. 105:11.
  Article PubMed CAS Google Scholar
• Petros, A., Bennett, D. and Valiance, P., 1991, Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock, Lancet 338:1557.
  Article PubMed CAS Google Scholar
• Pohl, U. and Busse, R., 1989, EDRF increases cyclic GMP in platelets during passage through the coronary vascular bed, Circ. Res. 65:1798.
  Article PubMed CAS Google Scholar
• Pohl, U., Busse, R., kuon, E. and Bassenge, E., 1986, Pulsatile perfusion stimulates the release of endothelial autacoids, J. Appl. Cardiol. 1:215.
  CAS Google Scholar
• Pronai, L., Ichimori, k., Nozaki, H., Nakazawa, H., Okino, H., Carmichael, A.J. and Arroyo, C.M., 1991, Investigation of the existence and biological role of L-arginine/nitric oxide pathway in human platelets by spin-trapping/EPR studies, Eur. J. Biochem. 202:923.
  Article PubMed CAS Google Scholar
• Radomski, M.W. and Moncada, S., 1991, Role of nitric oxide in endothelial cell-platelet interactions, in: Antithrombotics. Pathophysiological Rationale for Pharmacological Interventions, ed. Herman, A.G., Kluwer Academic Publishers, Dordrecht.
  Google Scholar
• Radomski, M.W., Palmer, R.M.J. and Moncada, S., 1987a, Comparative pharmacology of endothelium - derived relaxing factor, nitric oxide and prostacyclin in platelets, Br. J. Pharmacol. 92:181.
  Article CAS Google Scholar
• Radomski, M.W., Palmer, R.M.J. and Moncada, S., 1987b, Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium, Lancet ii:1057.
  Article Google Scholar
• Radomski, M.W., Palmer, R.M.J. and Moncada, S., 1987c, The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium, Biochem. Biophys. Res. Commun. 148:1482.
  Article CAS Google Scholar
• Radomski, M.W., Palmer, R.M.J. and Moncada, S., 1987d, The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide, Br. J. Pharmacol. 92:639.
  Article CAS Google Scholar
• Radomski, M.W., Palmer, R.M.J. and Moncada, S., 1988, Isolation and washing of human platelets with nitric oxide, Thromb. Res. 50:537.
  Article PubMed CAS Google Scholar
• Radomski, M.W., Palmer, R.M.J. and Moncada, S., 1990a, An L-Arginine/nitric oxide pathway present in human platelets regulates aggregation, Proc. Natl. Acad. Sci. USA 87:5193.
  Article CAS Google Scholar
• Radomski, M.W., Palmer, R.M.J. and Moncada, S., 1990b, Characterization of the L-argimne: nitric oxide pathway in human platelets, Br. J. Pharmacol. 101:325.
  Article CAS Google Scholar
• Radomski, M.W., Palmer, R.M.J. and Moncada, S., 1990c, Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells, Proc. Natl. Acad. Sci. USA 87:10043.
  Article CAS Google Scholar
• Radomski, M.W., Jenkins, D.C., Holmes, L. and Moncada, S., 1991a, Human colorectal adenocarcinoma cells: differential nitric oxide synthesis determines their ability to aggregate platelets, Cancer Res. 51:6073
  CAS Google Scholar
• Radomski, M.W., Martin, J.F. and Moncada, S., 1991b, Synthesis of nitric oxide by the haemocytes of the American horseshoe crab (Limulus polyphemus), Phil. Trans. R. Soc. Lond. B 334:129
  Article CAS Google Scholar
• Radomski, M.W., Rees, D.D., Dutra, A. and Moncada, S., 1992, S-nitroso-glutathione inhibits platelet activation in vitro and in vivo,Br. J. Pharmacol, 107; 745.
  Article PubMed CAS Google Scholar
• Rees, D.D., Cellek, S., Palmer, R.M.J. and Moncada, S., 1990, Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: an insight into endotoxin shock, Biochem. Biophys. Res. Comman. 173:541.
  Article CAS Google Scholar
• Remuzzi, G., Perico, N., Zoja, C., Corna, D., Macconi, D. and Vigano, G., 1990, Role of endothelium-derived nitric oxide in the bleeding tendency of uremia, J. Clin. Invest. 86:1768.
  Article PubMed CAS Google Scholar
• Rosenblum, W.I., Nelson, G.H. and Povlishock, J.T., 1987, Laser-induced endothelial damage inhibits endothelium-dependent relaxation in the cerebral microcirculation of the mouse, Circ. Res. 60:169.
  Article PubMed CAS Google Scholar
• Ross, R. and Glomset J A., 1976a, The pathogenesis of atherosclerosis (First of two parts), New Engl. J.Med. 295:369.
  Article CAS Google Scholar
• Ross, R. and Glomset, J.A., 1976b, The pathogenesis of atherosclerosis (Second of two parts), New Engl. J. Med. 295:420.
  Article CAS Google Scholar
• Rubanyi, G.M. and Vanhoutte, P.M., 1986, Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor, Am. J. Physiol. 250:H822.
  PubMed CAS Google Scholar
• Salvemini, D., de Nucci, G., Sneddon, J.M. and Vane, J.R., 1989, Superoxide anions enhance platelet adhesion and aggregation, Br. J. Pharmacol. 97:1145.
  Article PubMed CAS Google Scholar
• Sane, D.C., Bielawska, A., Greenberg, C.S. and Hannun, Y.A., 1989, Cyclic GMP analogs inhibit gthrombin-induced arachidonic acid release in human platelets, Biochem. Biophys. Res. Commun. 165:708.
  Article PubMed CAS Google Scholar
• Sinzinger, H., Virgolini, I., O’Grady, J., Rauscha, F. and Fitscha, P., 1992, Modification of platelet function by isosorbide dinitrate in patients with coronary artery disease, Thromb. Res. 65:323.
  Article PubMed CAS Google Scholar
• Sneddon, J.M. and Vane, J.R., 1988, Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells, Proc. Natl. Acad. Sci. USA 85:2800.
  Article PubMed CAS Google Scholar
• Souness, J.E., Diocee, B.K., Martin, W. and Moodie, S.A., 1990, Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells, Biochem. J. 266:127.
  PubMed CAS Google Scholar
• Stamler, J.S., Vaughan, D.E. and Loscalzo, J., 1989, Synergistic disaggregation of platelets by tissue-type plasminogen activator, prostaglandin E1,and glyceryl trinitrate, Circ. Res. 65:796.
  Article PubMed CAS Google Scholar
• Stamler, J.S., Simon, D.I., Osborne, J.A., Mullins, M.E., Jaraki, O., Michel, T., Singel, D.J. and Loscalzo, J., 1992, S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds, Proc. Natl. Acad. Sci. USA 89:444.
  Article PubMed CAS Google Scholar
• Valiance, P., Benjamin, N. and Collier, J., 1992, The effect of endothelium-derived nitric oxide on ex vivo whole blood platelet aggregation in man, Eur. J. Clin. Pharmacol. 42:37.
  Article Google Scholar
• Venturini, C.M., Del Vecchio, P.J. and Kaplan, J.E., 1989, Thrombin induced platelet adhesion to endothelium is modified by endothelial derived relaxing factor (EDRF). Biochem. Biophys. Res. Commun. 159:349.
  Article PubMed CAS Google Scholar
• Verbeuren, T.J., Jordaens, F.H., Zonnekeyn, L.L., Va Hove, C.E, Coene, M.C. and Herman, A.G., 1986, Effect of hypercholesterolemia on vascular reactivity in the rabbit. I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits, Circ. Res. 58:552.
  Article PubMed CAS Google Scholar
• Villaneuva, V.R. and Giret, M., 1980, Human platelet arginase, Mol. Cell. Biochem. 33:97.
  Google Scholar
• Walter, U., 1989, Physiological role of cGMP and cGMP-dependent protein kinase in the cardiovascular system, _Rev. Physiol. Biochem. Pharmacol._113:41.
  Article PubMed CAS Google Scholar
• Ware, J.A., Smith, M. and Salzman, E.W., 1987, Synergism of platelet-aggregating agents. Role of elevation of cytoplasmic calcium, J. Clin. Invest. 80:267.
  Article PubMed CAS Google Scholar
• Wautier, J.L., Weill, D., Kadeva, H., Maclouf, J. and Soria, C., 1989, Modulation of platelet function by SIN-1A, a metabolite of molsidomine, J. Cardiovasc. Pharmacol. 14:S111.
  PubMed CAS Google Scholar
• Whittle, B.J.R., Moncada, S. and Vane, J.R., 1978, Comparison of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species, Prostaglandins 16:373.
  PubMed CAS Google Scholar

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