The Initiation and Function of Th2 Responses during Infection with Schistosoma Mansoni (original) (raw)

Abstract

Schistosomes, like most other parasitic helminths, induce strong type-2 responses in which the Th2-cell defining cytokines (IL-4, -5, -6, -13 and others) are produced by Th cells and additional cell types such as basophils and eosinophils(1)–(3). Since mice are susceptible to infection with Schistosoma mansoni, one of the major schistosome parasites of humans, and develop a disease similar to human schistosomiasis, it has been possible to use this experimental host/parasite system to ask specific questions about the induction and function of the type 2 response during infection.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, USA
    Edward J. Pearce, Anne La Flamme & Laura Rosa Brunet
  2. Heska Corporation, Fort Collins, Colorado, 80525, USA
    Elizabeth Sabin

Authors

  1. Edward J. Pearce
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  2. Anne La Flamme
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  3. Elizabeth Sabin
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  4. Laura Rosa Brunet
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Editor information

Editors and Affiliations

  1. University of California, Irvine, Irvine, California, USA
    Sudhir Gupta
  2. National Institutes of Health, Bethesda, Maryland, USA
    Alan Sher
  3. Emory University, Atlanta, Georgia, USA
    Rafi Ahmed

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Pearce, E.J., La Flamme, A., Sabin, E., Brunet, L.R. (1998). The Initiation and Function of Th2 Responses during Infection with Schistosoma Mansoni . In: Gupta, S., Sher, A., Ahmed, R. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VII. Advances in Experimental Medicine and Biology, vol 452. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5355-7\_9

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