Analysis and Pathogenetic Significance of Class II MHC (Ia) Antigen Induction on Astrocytes During JHM Coronavirus Infection in Rats (original) (raw)

Abstract

This laboratory has developed over the past several years a rat model for virus-induced1, 2, 3 central nervous system (CNS) disease involving inflammatory demyelinating lesions. The JHM strain of murine hepatitis coronavirus causes an array of neurological diseases differing in complexity depending on factors associated with the age and genetic background of the host4 and the particular JHM virus isolate utilized5. Factors related to the age and genetics of the host associated with susceptibility to disease appear to involve immunological function4, whereas factors related to the virus appear to depend on functional aspects of the E2 envelope glycoprotein4, 6, 7 (Wege et al., this volume).

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References

  1. K. Nagashima, H. Wege, R. Meyermann, and V. ter Meulen, Corona virus induced subacute demyelinating encephalomyelitis in rat: a morphological analysis. Acta Neuropathol 44: 63 (1978).
    Article PubMed CAS Google Scholar
  2. K. Nagashima, H. Wege, R. Meyermann, and V. ter Meulen, Demyelinating encephalomyelitis induced by a long-term coronavirus infection in rats. Acta Neuropathol 45: 205 (1979).
    Article PubMed CAS Google Scholar
  3. H. Wege, R. Watanabe, and V. ter Meulen, Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection. J. Neuroimmunol 6: 325 (1984).
    Article PubMed CAS Google Scholar
  4. H. Wege, P.T. Massa, R. Dörries, R. Watanabe, and V. ter Meulen, Coronavirus infection of rats: a model for virus induced demyelinating disease associated with autoimmunity, in: Modern Trends in Virology (Bauer et al., eds., Springer Verlag (1986) (in press).
    Google Scholar
  5. H. Wege, J.R. Stephenson, M. Koga, H. Wege, and V. ter Meulen, Genetic variation of neurotropic and non-neurotropic murine coronaviruses. J Gen Virol 54: 67 (1981).
    Article PubMed CAS Google Scholar
  6. H.M. Baybutt, H. Wege, M.J. Carter, and V. ter Meulen, Adaptation of coronavirus JHM to persistent infection of murine Sac(−) cells. J Gen Virol 65: 915 (1984).
    Article PubMed Google Scholar
  7. H. Wege, R. Dörries, and H. Wege, Hybridoma antibodies to the murine coronavirus JHM: characterization of epitopes on the peplomer protein (E2). J Gen Virol 65: 1931 (1984).
    Article PubMed CAS Google Scholar
  8. P.T. Massa, H. Wege, and V. ter Meulen, Analysis of murine hepatitis virus (JHM strain) tropism toward Lewis rat glial cells in vitro: Type I astrocytes and brain macrophages (microglia) as primary glial cell targets. Lab Invest 55: 318 (1986).
    PubMed CAS Google Scholar
  9. E. Barbarese and S.E. Pfeiffer, Developmental regulation of myelin basic protein in dispersed cultures. Proc Natl Acad Sci USA 78: 1953 (1983).
    Article Google Scholar
  10. A.G. Walker, J. Chapman, C.B. Bruce, and M.G. Rumsby, Immunocytochemical characterization of cell cultures grown from dissociated 1–2 day post-natal rat cerebral tissue: a developmental study. J Neuroimmunol 7: 1 (1985).
    Article Google Scholar
  11. B.L. Padgett and D.L. Walker, New human papovaviruses. Prog Med Virol 22: 1 (1976).
    PubMed CAS Google Scholar
  12. W.F. Hickey, N.K. Gonatas, H. Kimura, and D.B. Wilson, Identification and quantitation of T-lymphocyte subsets found in the spinal cord of the Lewis rat during acute experimental allergic encephalomyelitis. J Immunol 131: 2805 (1983).
    PubMed CAS Google Scholar
  13. R. Watanabe, H. Wege, and V. ter Meulen, Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demyelinating encephalomyelitis. Nature 305: 150 (1983).
    Article PubMed CAS Google Scholar
  14. A. Fontana, W. Fierz, and H. Wekerle, Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature 307: 273 (1984).
    Article PubMed CAS Google Scholar
  15. A. Ben-Nun, H. Wekerle, and I.R. Cohen, The rapid isolation of clonable antigen-specific T-lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur J Immunol 11: 195 (1981).
    Article PubMed CAS Google Scholar
  16. K. Sakai, T. Tabira, M. Endoh, and L. Steinman, la expression in chronic relapsing experimental allergic encephalomyelitis induced by long-term cultured T cell lines in mice. Lab Invest 54: 345 (1986).
    PubMed CAS Google Scholar
  17. S. Sriram, and L. Steinman, Anti I-A antibody suppresses active encephalomyelitis: Treatment model for diseases linked to IR genes. J Exp Med 158: 1362 (1983).
    Article PubMed CAS Google Scholar
  18. P.T. Massa, R. Dörries, and V. ter Meulen, Viral particles induce la antigen expression on astrocytes. Nature 320: 543 (1986).
    Article PubMed CAS Google Scholar
  19. W.H. Yap, T.S. Teo, Y.H. Tan, An early event in the interferon-induced transmembrane signaling process. Science 234: 355 (1986).
    Article PubMed CAS Google Scholar
  20. T.A. Hamilton, J.E. Rigsbee, W.A. Scott, and D.O. Adams, Gamma-interferon enhances the secretion of arachidonic acid metabolites from murine peritoneal macrophages stimulated with phorbol diesters. J Immunol 134: 2631 (1985).
    PubMed CAS Google Scholar
  21. G.G.B. Klaus, A. O’Garra, M.K. Bijsterbosch, and M. Holman, Activation and proliferation signals in mouse B-cells. VIII. Induction of DNA synthesis in B-cells by a combination of calcium ionophores and phorbol myristate acetate. Eur J Immunol 16: 92 (1986).
    Article PubMed CAS Google Scholar
  22. E. Günther, H. Odenthal, and W. Wechsler, Association between susceptibility to experimental allergic encephalomyelitis and the major histocompatibility system in congenic rat strains. Clin. exp. Immunol. 32: 429 (1978).
    PubMed Google Scholar

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Authors and Affiliations

  1. Institute of Virology and Immunobiology, University of Würzburg, Versbacher Str. 7, D-8700, Würzburg, Germany
    Paul T. Massa, Rüdiger Dörries, Helmut Wege & Volker ter Meulen

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  1. Paul T. Massa
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  2. Rüdiger Dörries
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  3. Helmut Wege
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  4. Volker ter Meulen
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Editors and Affiliations

  1. University of Southern California School of Medicine, Los Angeles, California, USA
    Michael M. C. Lai & Stephen A. Stohlman &

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Massa, P.T., Dörries, R., Wege, H., ter Meulen, V. (1987). Analysis and Pathogenetic Significance of Class II MHC (Ia) Antigen Induction on Astrocytes During JHM Coronavirus Infection in Rats. In: Lai, M.M.C., Stohlman, S.A. (eds) Coronaviruses. Advances in Experimental Medicine and Biology, vol 218. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1280-2\_25

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