Oxidative Stress, Poly(ADP)Ribosylation and Aging: In Vitro Studies on Lymphocytes from Normal and Down’s Syndrome Subjects of Different Age and from Patients with Alzheimer’s Dementia (original) (raw)
Abstract
Free radicals are formed in the body as a consequence of aerobic metabolism. Cells have developed a variety of antioxidant systems, that include classical antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase) as well as nonenzymatic oxy-radicals scavengers (vitamin E, urea, ß-carotene and some more recently described substances such as carnosine) (1). However, a certain fraction of active oxygen species escapes the cellular defence and may cause transient or permanent damage to cellular components. According to one of the most interesting theory of aging is the “free radical theory of aging”, proposed by D. Harman (2) more than thirty years ago, where oxidative damage has been suggested as a major cause of aging. One of the prediction of this theory is an age-related decrease of the efficiency of antioxidant defence mechanisms.
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
- R. Kohen, Y. Yamamoto, K.C. Cundy, and B.N. Ames, Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc. Natl. Acad. Sci. (USA) 85: 3175 (1988).
Article CAS Google Scholar - D. Harman, A theory based on free radicals and radiation chemistry. J. Gerontol. 11: 298 (1956).
PubMed CAS Google Scholar - D.R. Spitz, W.C. Dewey, and C.G. Li, Hydrogen peroxide or heat shock induced resistance to hydrogen peroxide in Chinese hamster fibroblasts, J. Cell Physiol. 131: 364 (1987).
Article PubMed CAS Google Scholar - S. Shall, ADP-ribosylation of proteins: a ubiquitous cellular control mechanism. In: Advances in post-translational modifications of proteins and aging, V. Zappia, P.Galletti, R.Porta and F. Wold eds, Plenum Press, NY 1988.
Google Scholar - J.E. Cleaver, C.Borek, K. Milam, and W.F. Morgan, The role of poly (ADP-ribose) synthesis ion toxicity and repair of DNA damage, Pharmacol. Ther. 31: 269 (1987).
Article Google Scholar - D.A., Carson, S. Seto, and B. Wasson, Lymphocyte disfunction after DNA damage by toxic oxygen species. A model for immunodeficiency. J. Exp. Med. 163: 746 (1986).
Article PubMed CAS Google Scholar - C. Franceschi, F. Licastro, M. Chiricolo, M. Zannotti, and M. Masi, Premature senility in Down’s syndrome: a model for and an approach to the molecular genetic of the ageing process. In: Immunoregulation in Aging, A. Facchini, J.J. Harman, and G. Labó, Eurage, Rijswijk (1986).
Google Scholar - J. Kedziora and G. Bartosz, Down’s syndrome: a pathology involving the lack of balance of reactive oxygen species, Free Rad. Biol. Med. 4: 317 (1988).
Article PubMed CAS Google Scholar - P. Sola, E. Merelli, P. Faglioni, D. Monti, A Cossarizza, and C. Franceschi, DNA repair, sensitivity to gamma radiation and to heat shock in lymphocytes from acute, untreated multiple sclerosis patients, J. Neuroimmunol. 21: 23 (1989).
Article PubMed CAS Google Scholar
Author information
Authors and Affiliations
- Istituto di Patologia generale, via Campi 287, 41100, Modena, Italy
C. Franceschi, D. Monti, A. Cossarizza & A. Tomasi - Clinica Neurologica, Universitá di Modena, Italy
P. Sola - Istituto di Istologia ed Embriologia generale, Universitá di Bologna, Italy
M. Zannotti
Authors
- C. Franceschi
You can also search for this author inPubMed Google Scholar - D. Monti
You can also search for this author inPubMed Google Scholar - A. Cossarizza
You can also search for this author inPubMed Google Scholar - A. Tomasi
You can also search for this author inPubMed Google Scholar - P. Sola
You can also search for this author inPubMed Google Scholar - M. Zannotti
You can also search for this author inPubMed Google Scholar
Editor information
Editors and Affiliations
- Centre National de la Recherche Scientifique, University of Paris, Paris, France
Ingrid Emerit - Dept. of Physiology Anatomy, University of California, Berkeley, Berkeley, California, 94720, USA
Lester Packer - Institut Gustave-Roussy, 94800, Villejuif, France
Christian Auclair - Groupe de Recherche Radicaux Libres, Institut Biomédical des Cordeliers, 15, Rue de l’Ecole de Médecine, 75006, Paris, France
Ingrid Emerit
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Franceschi, C., Monti, D., Cossarizza, A., Tomasi, A., Sola, P., Zannotti, M. (1990). Oxidative Stress, Poly(ADP)Ribosylation and Aging: In Vitro Studies on Lymphocytes from Normal and Down’s Syndrome Subjects of Different Age and from Patients with Alzheimer’s Dementia. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8\_76
Download citation
- .RIS
- .ENW
- .BIB
- DOI: https://doi.org/10.1007/978-1-4684-5730-8\_76
- Publisher Name: Springer, Boston, MA
- Print ISBN: 978-1-4684-5732-2
- Online ISBN: 978-1-4684-5730-8
- eBook Packages: Springer Book Archive