The Plasma Membrane ‘Skeleton’ of Tumor and Lymphoid Cells: A Role in Cell Lysis? (original) (raw)

Abstract

A detailed understanding of the structure and dynamics of the surface membrane of cells is crucial to study of the mechanisms of cell mediated cytotoxicity. The dynamics of the membrane receptors, target cell antigens and accessory proteins almost certainly affect the efficiency of establishing and maintaining cell-cell contact and delivery of the transmembrane signal resulting in triggering of the lytic mechanisms. Furthermore, whether the primary event involved in target cell lysis is formation of membrane lesions (pore formation) or transfer of a lytic component (enzyme?) from the effector cell to the target, the molecular requirements for these events will certainly depend upon the structure and dynamics of the target cell plasma membrane.

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Authors and Affiliations

  1. Department of Pathology, Harvard Medical School, 25 Shattuck Street, 02115, Boston, Massachusetts, USA
    Matthew F. Mescher & John R. Apgar

Authors

  1. Matthew F. Mescher
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  2. John R. Apgar
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA
    Pierre Henkart
  2. University of Massachusetts, Amherst, Massachusetts, USA
    Eric Martz

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© 1985 Plenum Press, New York

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Mescher, M.F., Apgar, J.R. (1985). The Plasma Membrane ‘Skeleton’ of Tumor and Lymphoid Cells: A Role in Cell Lysis?. In: Henkart, P., Martz, E. (eds) Mechanisms of Cell-Mediated Cytotoxicity II. Advances in Experimental Medicine and Biology, vol 184. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-8326-0\_26

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