Evaluation of Brown Adipose Tissue Using Near-Infrared Time-Resolved Spectroscopy (original) (raw)

Abstract

Human brown adipose tissue (BAT) activity (SUVmax) has been typically evaluated by 18F-fluorodeoxy glucose (FDG)–positron emission tomography (PET) combined with computed tomography (CT). In this study, the objective was to detect human BAT by near-infrared time-resolved spectroscopy (NIRTRS), a noninvasive and simple method for measuring total hemoglobin concentration [total-Hb] and reduced scattering coefficient (μs′) in the tissue. The [total-Hb] in the supraclavicular region of the BAT (+) (SUVmax ≥ 2.0) group was 95.0 ± 28.2 μM (mean +/− SD), which was significantly higher than that of the BAT (−) (SUVmax < 2.0) group (52.0 ± 14.8 μM), but not in other regions apart from the BAT deposits. The μs′ in the supraclavicular region of the BAT (+) group was 8.4 ± 1.7 cm−1, which was significantly higher than that of BAT (−) group (4.3 ± 1.0 cm−1), but not in other regions. The area under the receiver operating characteristic curve closest to (0, 1) for [total-Hb] and μs′ to discriminate BAT (+) from BAT (−) was 72.5 μM and 6.3 cm−1, respectively. The sensitivity, specificity, and accuracy for both parameters were 87.5, 100, and 93.3 %, respectively. Our novel NIRTRS method is noninvasive, simple, and inexpensive compared with FDG-PET/CT, and is reliable for detecting human BAT.

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Authors and Affiliations

  1. Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, Kyoto, 612-8555, Japan
    Shinsuke Nirengi
  2. Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Takeshi Yoneshiro
  3. Graduate School of Sport and Health Science, Ritsumeikan University, Kusatsu, Japan
    Takeshi Saiki
  4. Department of Food and Nutrition, Hakodate Junior College, Hakodate, Japan
    Sayuri Aita
  5. Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo, Japan
    Mami Matsushita
  6. LSI Sapporo Clinic, Sapporo, Japan
    Hiroki Sugie
  7. Hokkaido University, Sapporo, Japan
    Masayuki Saito
  8. Department of Sports Medicine for Health Promotion, Tokyo Medical University, Shinjyuku, Japan
    Takafumi Hamaoka

Authors

  1. Shinsuke Nirengi
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  2. Takeshi Yoneshiro
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  3. Takeshi Saiki
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  4. Sayuri Aita
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  5. Mami Matsushita
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  6. Hiroki Sugie
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  7. Masayuki Saito
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  8. Takafumi Hamaoka
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Corresponding author

Correspondence toTakafumi Hamaoka .

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Editors and Affiliations

  1. Department of Medical Physics & Biomedical Engineering, University College London, London, UK
    Clare E. Elwell & Terence S. Leung &
  2. Microvascular Measurements, St. Lorenzen, Italy
    David K. Harrison

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Nirengi, S. et al. (2016). Evaluation of Brown Adipose Tissue Using Near-Infrared Time-Resolved Spectroscopy. In: Elwell, C.E., Leung, T.S., Harrison, D.K. (eds) Oxygen Transport to Tissue XXXVII. Advances in Experimental Medicine and Biology, vol 876. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3023-4\_46

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