Detection and Analysis of Somatic Mutations at a lacZ Reporter Locus in Higher Organisms (original) (raw)

References

  1. Vijg, J. (2000) Somatic mutations and aging: a re-evaluation. Mutat. Res. 447, 117–135.
    CAS PubMed Google Scholar
  2. Vijg, J. and Dollé, M. E. (2002) Large genome rearrangements as a primary cause of aging. Mech. Ageing Dev. 123, 907–915.
    Article CAS PubMed Google Scholar
  3. Fukuchi, K., Martin, G. M., and Monnat, R. J., Jr. (1989) Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc. Natl. Acad. Sci. USA 86, 5893–5897.
    Article CAS PubMed Google Scholar
  4. Gossen, J. A., de Leeuw, W. J., Tan, H., et al. (1989) Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc. Natl. Acad. Sci. USA 86, 7971–7975.
    Article CAS PubMed Google Scholar
  5. Boerrigter, M. E., Dolle, M. E., Martus, H. J., Gossen, J. A., and Vijg, J. (1995) Plasmid-based transgenic mouse model for studying in vivo mutations. Nature 377, 657–659.
    Article CAS PubMed Google Scholar
  6. Szilard, L. (1959) On the nature of the aging process. Proc. Natl. Acad. Sci. USA 45, 30–45.
    Article CAS PubMed Google Scholar
  7. Dollé, M. E., Giese, H., Hopkins, L., Martus, H. J., Hausdorff, J. M., and Vijg, J. (1997) Rapid accumulation of genome rearrangements in liver but not in brain of old mice. Nat. Genet. 17, 431–434.
    Article PubMed Google Scholar
  8. Dollé, M. E., Snyder, W. Gossen, J. A., Lohman, P. H., and Vijg, J. (2000) Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. Proc. Natl. Acad. Sci. USA 97, 8403–8408.
    Article PubMed Google Scholar
  9. Dollé, M. E. and Vijg, J. (2002) Genome dynamics in aging mice. Genome Res. 12, 1732–1738.
    Article PubMed Google Scholar
  10. Dollé, M. E., Martus, H. J., Gossen, J. A., Boerrigter, M. E., and Vijg, J. (1996) Evaluation of a plasmid-based transgenic mouse model for detecting in vivo mutations. Mutagenesis 11, 111–118.
    Article PubMed Google Scholar
  11. Gossen, J. A., Martus, H. J., Wei, J. Y., and Vijg, J. (1995) Spontaneous and X-rayinduced deletion mutations in a LacZ plasmid-based transgenic mouse model. Mutat. Res. 331, 89–97.
    CAS PubMed Google Scholar
  12. Busuttil, R. A., Rubio, M., Dollé, M. E., Campisi, J., and Vijg, J. (2006) Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lac-plasmid reporter mice. DNA Repair 5(1), 52–60.
    Article Google Scholar
  13. Dollé, M. E., Snyder, W. van Orsouw, N. J., and Vijg, J. (1999) Background mutations and polymorphisms in lacZ-plasmid transgenic mice. Environ. Mol. Mutagen 34, 112–120.
    Article PubMed Google Scholar
  14. Dolle, M. E., Martus, H. J., Novak, M., van Orsouw, N. J., and Vijg, J. (1999) Characterization of color mutants in lacZ plasmid-based transgenic mice, as detected by positive selection. Mutagenesis 14, 287–293.
    Article CAS PubMed Google Scholar
  15. Dollé, M. E., Busuttil, R. A., Garcia, A. M., et al. (2006) Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutat. Res. 596, 22–35.
    PubMed Google Scholar

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