Helicobacter -Based Mouse Models of Digestive System Carcinogenesis (original) (raw)

References

1. Shibuya, K., Mathers, C. D., Boschi-Pinto, C., Lopez, A. D., and Murray, C. J. (2002) Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000._BMC Cancer_2, 37.
   Article PubMed Google Scholar
2. Bleich, A. and Mahler, M. (2005) Environment as a critical factor for the pathogen-esis and outcome of gastrointestinal disease: experimental and human inflammatory bowel disease and_Helicobacter_-induced gastritis._Pathobiology_72, 293–307.
   Article CAS PubMed Google Scholar
3. Parkin, D. M. (2006) The global health burden of infection-associated cancers in the year 2002._Int J Cancer_118, 3030–3044.
   Article CAS PubMed Google Scholar
4. Rogers, A. B. and Fox, J. G. (2004) Inflammation and cancer. I. Rodent models of infectious gastrointestinal and liver cancer._Am J Phys-iol Gastrointest Liver Physiol_286, G361–366.
   Article CAS Google Scholar
5. Fox, J. G. and Wang, T. C. (2007) Inflammation, atrophy, and gastric cancer._J Clin Invest_117, 60–69.
   Article CAS PubMed Google Scholar
6. Zhang, L. and Mitchell, H. (2006) The roles of mucus-associated bacteria in inflammator y bowel disease._Drugs Today (Barc)_42, 605–616.
   Article CAS PubMed Google Scholar
7. Waterston, R. H., Lindblad-Toh, K., Birney, E., Rogers, J., Abril, J. F., Agarwal, P., et al. (2002) Initial sequencing and comparative analysis of the mouse genome._Nature_420, 520–562.
   Article CAS PubMed Google Scholar
8. Syder, A. J., Oh, J. D., Guruge, J. L., O'Donnell, D., Karlsson, M., Mills, J. C., et al. (2003) The impact of parietal cells on_Helicobacter pylori_tropism and host pathology: an analysis using gnotobiotic normal and transgenic mice._Proc Natl Acad Sci USA_100, 3467–3472.
   Article CAS PubMed Google Scholar
9. Rogers, A. B., Theve, E. J., Feng, Y., Fry, R. C., Taghizadeh, K., Clapp, K. M., et al. (2007) Hepatocellular carcinoma associated with liver-gender disruption in male mice._Cancer Res_67, 11536–11546.
   Article CAS PubMed Google Scholar
10. Backhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., and Gordon, J. I. (2005) Host-bacterial mutualism in the human intestine._Science_307, 1915–1920.
    Article PubMed Google Scholar
11. Maurer, K. J., Ihrig, M. M., Rogers, A. B., Ng, V., Bouchard, G., Leonard, M. R., et al. (2005) Identification of cholelithogenic enterohepatic_Helicobacter_species and their role in murine cholesterol gallstone formation._Gastroentero-logy_128, 1023–1033.
    Article CAS Google Scholar
12. Moss, S. F. and Malfertheiner, P. (2007)_Heli-cobacter_and gastric malignancies._Helicobacter_12(1), 23–30.
    Article CAS PubMed Google Scholar
13. Fox, J. G., Rogers, A. B., Ihrig, M., Taylor, N. S., Whary, M. T., Dockray, G., et al. (2003)_Helicobacter pylori_-associated gastric cancer in INS-GAS mice is gender specific._Cancer Res_63, 942–950.
    CAS PubMed Google Scholar
14. Fox, J. G., Wang, T. C., Rogers, A. B., Pou-tahidis, T., Ge, Z., Taylor, N., et al. (2003) Host and microbial constituents influence_Helicobacter pylori_-induced cancer in a murine model of hypergastrinemia._Gastroenterology_124, 1879–1890.
    Article PubMed Google Scholar
15. Fox, J. G., Rogers, A. B., Whary, M. T., Ge, Z., Ohtani, M., Jones, E. K., et al. (2007) Accelerated Progression of gastritis to dysplasia in the pyloric antrum of TFF2−/−C57BL6 x Sv129_Helicobacter pylori_-infected mice._Am J Pathol_171, 1520–1528.
    Article CAS PubMed Google Scholar
16. Whar y, M. T. and Fox, J. G. (2004) Th1-mediated pathology in mouse models of human disease is ameliorated by concurrent Th2 responses to parasite antigens._Curr Top Med Chem_4, 531–538.
    Google Scholar
17. Lee, A., O'Rourke, J., and Enno, A. (2000) Gastric mucosa-associated lymphoid tissue lymphoma: implications of animal models on pathogenic and therapeutic considerations– mouse models of gastric lymphoma._Recent Results Cancer Res_156, 42–51.
    CAS PubMed Google Scholar
18. Lee, A., Fox, J. G., Otto, G., and Murphy, J. (1990) A small animal model of human_Helicobacter pylori_active chronic gastritis._Gastroenterology_99, 1315–1323.
    CAS PubMed Google Scholar
19. De Bock, M., D'Herde, K., Duchateau, L., Hellemans, A., Decostere, A., Haesebrouck, F., et al. (2006) The effect of_Helicobacter felis_and_Helicobacter bizzozeronii_on the gastric mucosa in Mongolian gerbils: a sequential pathological study._J Comp Pathol_135, 226–236.
    Article PubMed Google Scholar
20. Gasbarrini, A., Carloni, E., Gasbarrini, G., and Menard, A. (2003)Helicobacter pylori_and extragastric diseases – other_Helicobacters._Helicobacter_8(1), 68–76.
    Article PubMed Google Scholar
21. McCracken, V. J., Martin, S. M., and Lorenz, R. G. (2005) The_Helicobacter felis_model of adoptive transfer gastritis._Immunol Res_33, 183–194.
    Article CAS PubMed Google Scholar
22. Fox, J. G., Sheppard, B. J., Dangler, C. A., Whary, M. T., Ihrig, M., and Wang, T. C. (2002) Germ-line p53-targeted disruption inhibits helicobacter-induced premalignant lesions and invasive gastric carcinoma through down- regulation of Th1 proinflammatory responses._Cancer Res_62, 696–702.
    CAS PubMed Google Scholar
23. Fox, J. G., Blanco, M., Murphy, J. C., Taylor, N. S., Lee, A., Kabok, Z., et al. (1993) Local and systemic immune responses in murine_Helicobacter felis_active chronic gastritis._Infect Immun_61, 2309–2315.
    CAS PubMed Google Scholar
24. Lee, A., Hazell, S. L., O'Rourke, J., and Kou-prach, S. (1988) Isolation of a spiral-shaped bacterium from the cat stomach._Infect Immun_56, 2843–2850.
    CAS PubMed Google Scholar
25. Mohammadi, M., Redline, R., Nedrud, J., and Czinn, S. (1996) Role of the host in patho-genesis of_Helicobacter_-associated gastritis:_H. felis_infection of inbred and congenic mouse strains._Infect Immun_64, 238–245.
    CAS PubMed Google Scholar
26. Fox, J. G., Beck, P., Dangler, C. A., Whary, M. T., Wang, T. C., Shi, H. N., et al. (2000) Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces_Helicobacter_-induced gastric atrophy._Nat Med_6, 536–542.
    Article CAS PubMed Google Scholar
27. Stoicov, C., Whary, M., Rogers, A. B., Lee, F. S., Klucevsek, K., Li, H., et al. (2004) Coinfec-tion modulates inflammatory responses and clinical outcome of_Helicobacter felis_and_Toxoplasma gondii_infections._J Immunol_173, 3329–3336.
    CAS PubMed Google Scholar
28. Fox, J. G. and Lee, A. (1993) Gastric helico-bacter infection in animals: natural and experimental infections. In Biology and Clinical Practice (Goodwin, C. and Worsley, B., eds), pp. 407–430, CRC Press, Boca Raton.
    Google Scholar
29. Lee, A., O'Rourke, J., De Ungria, M. C., Robertson, B., Daskalopoulos, G., and Dixon, M. F. (1997) A standardized mouse model of_Helico-bacter pylori_infection: introducing the Sydney strain._Gastroenterology_112, 1386–1397.
    Article CAS PubMed Google Scholar
30. Rogers, A. B., Taylor, N. S., Whary, M. T., Stefanich, E. D., Wang, T. C., and Fox, J. G. (2005)_Helicobacter pylori_but not high salt induces gastric intraepithelial neoplasia in B6129 mice._Cancer Res_65, 10709–10715.
    Article CAS PubMed Google Scholar
31. Peek, R. M., Jr. and Blaser, M. J. (2002)_Heli-cobacter pylori_and gastrointestinal tract aden-ocarcinomas._Nat Rev Cancer_2, 28–37.
    Article CAS PubMed Google Scholar
32. Pritchard, D. M. and Przemeck, S. M. (2004) Review article: how useful are the rodent animal models of gastric adenocarcinoma?_Aliment Pharmacol Ther_19, 841–859.
    Article CAS PubMed Google Scholar
33. Friis-Hansen, L., Rieneck, K., Nilsson, H. O., Wadstrom, T., and Rehfeld, J. F. (2006) Gastric inflammation, metaplasia, and tumor development in gastrin-deficient mice._Gastro-enterology_131, 246–258.
    Article CAS Google Scholar
34. Wang, T. C., Dangler, C. A., Chen, D., Gold-enring, J. R., Koh, T., Raychowdhury, R., et al. (2000) Synergistic interaction between hypergastrinemia and_Helicobacter_infection in a mouse model of gastric cancer._Gastroenter-ology_118, 36–47.
    Article CAS Google Scholar
35. Stenstrom, B., Zhao, C. M., Rogers, A. B., Nilsson, H. O., Sturegard, E., Lundgren, S., et al. (2007) Swedish moist snuff accelerates gastric cancer development in_Helicobacter pylori_-infected wild-type and gastrin trans-genic mice._Carcinogenesis_28(9), 2041–2046
    Article PubMed Google Scholar
36. Ohtani, M., Garcia, A., Rogers, A. B., Ge, Z., Taylor, N. S., Xu, S., et al. (2007) Protective role of 17{beta}-estradiol against the development of_Helicobacter pylori_-induced gastric cancer in INS-GAS mice._Carcinogenesis_28, 2597–2604.
    Article CAS PubMed Google Scholar
37. Kuzushita, N., Rogers, A. B., Monti, N. A., Whary, M. T., Park, M. J., Aswad, B. I., et al. (2005) p27kip1 deficiency confers susceptibility to gastric carcinogenesis in_Helicobacter pylori_-infected mice._Gastroenterology_129, 1544–1556.
    Article CAS PubMed Google Scholar
38. Xia, H. H., Yang, Y., Lam, S. K., Wong, W. M., Leung, S. Y., Yuen, S. T., et al. (2004) Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in_Helicobacter pylori_infected gastric antrum, incisura, and body and its association with antralisation._J Clin Pathol_57, 861–866.
    Article CAS PubMed Google Scholar
39. Nomura, S., Baxter, T., Yamaguchi, H., Leys, C., Vartapetian, A. B., Fox, J. G., et al. (2004) Spasmolytic polypeptide expressing metaplasia to preneoplasia in_H. felis_-infected mice._Gastroenterology_127, 582–594.
    Article CAS PubMed Google Scholar
40. Kang, W., Rathinavelu, S., Samuelson, L. C., and Merchant, J. L. (2005) Interferon gamma induction of gastric mucous neck cell hypertrophy._Lab Invest_85, 702–715.
    Article CAS PubMed Google Scholar
41. Goldenring, J. R. and Nomura, S. (2006) Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia._Am J Physiol Gastrointest Liver Physiol_291, G999–1004.
    Article CAS PubMed Google Scholar
42. Kurt-Jones, E. A., Cao, L., Sandor, F., Rogers, A. B., Whary, M. T., Nambiar, P. R., et al. (2007) Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses._Infect Immun_75, 471–480.
    Article CAS PubMed Google Scholar
43. Farrell, J. J., Taupin, D., Koh, T. J., Chen, D., Zhao, C. M., Podolsky, D. K., et al. (2002) TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury._J Clin Invest_109, 193–204.
    CAS PubMed Google Scholar
44. Correa, P. (1985) Mechanisms of gastric carcino-genesis. In Diet and Human Carcinogenesis (Joosens, J., et al., eds), pp. 109–115, Elsevier, Amsterdam.
    Google Scholar
45. Correa, P. and Houghton, J. (2007) Carcino-genesis of_Helicobacter pylori_._Gastroenterology_133, 659–672.
    Article CAS PubMed Google Scholar
46. Stolte, M. and Meining, A. (2001) The updated Sydney system: classification and grading of gastritis as the basis of diagnosis and treatment._Can J Gastroenterol_15, 591–598.
    CAS PubMed Google Scholar
47. Ming, S.-C. and Hirota, T. (1998) Malignant epithelial tumors of the stomach. In Pathology of the Gastrointestinal Tract (2nd edn) (Ming, S.-C. and Goldman, H., eds), pp. 607–650, Williams & Wilkins, Baltimore.
    Google Scholar
48. Boivin, G. P., Washington, K., Yang, K., Ward, J. M., Pretlow, T. P., Russell, R., et al. (2003) Pathology of mouse models of intestinal cancer: consensus report and recommendations._Gas-troenterology_124, 762–777.
    Article Google Scholar
49. Ward, J. M., Yoon, M., Anver, M. R., Haines, D. C., Kudo, G., Gonzalez, F. J., et al. (2001) Hyalinosis and Ym1/Ym2 gene expression in the stomach and respiratory tract of 129S4/ SvJae and wild-type and CYP1A2-null B6, 129 mice._Am J Pathol_158, 323–332.
    Article CAS PubMed Google Scholar
50. Haines, D. C., Chattopadhyay, S., and Ward, J. M. (2001) Pathology of aging B6;129 mice._Toxicol Pathol_29, 653–661.
    Article CAS PubMed Google Scholar
51. Cardiff, R. D., Ward, J. M., and Barthold, S. W. (2007) ‘One medicine-one pathology’: are veterinary and human pathology prepared?_Lab Invest_88(1), 18–26.
    Article PubMed Google Scholar
52. Houghton, J., Stoicov, C., Nomura, S., Rogers, A. B., Carlson, J., Li, H., et al. (2004) Gastric cancer originating from bone marrow-derived cells._Science_306, 1568–1571.
    Article CAS PubMed Google Scholar
53. Cendan, J. C. and Behrns, K. E. (2007) Associated neoplastic disease in inflammatory bowel disease._Surg Clin North Am_87, 659–672.
    Article PubMed Google Scholar
54. Taylor, N. S., Xu, S., Nambiar, P., Dewhirst, F. E., and Fox, J. G. (2007) Enterohepatic_Helicobacter_species are prevalent in mice from commercial and academic institutions in Asia, Europe, and North America._J Clin Microbiol_45, 2166–2172.
    Article CAS PubMed Google Scholar
55. Dieleman, L. A., Arends, A., Tonkonogy, S. L., Goerres, M. S., Craft, D. W., Grenther, W., et al. (2000)_Helicobacter hepaticus_does not induce or potentiate colitis in interleukin-10-deficient mice._Infect Immun_68, 5107–5113.
    Article CAS PubMed Google Scholar
56. Takaishi, H., Matsuki, T., Nakazawa, A., Takada, T., Kado, S., Asahara, T., et al. (2007) Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease._Int J Med Micro-biol_298(5–6), 463–472.
    Google Scholar
57. Suerbaum, S., Josenhans, C., Sterzenbach, T., Drescher, B., Brandt, P., Bell, M., et al. (2003) The complete genome sequence of the carcinogenic bacterium_Helicobacter hepaticus_._Proc Natl Acad Sci USA_100, 7901–7906.
    Article CAS PubMed Google Scholar
58. Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K., and Muller, W. (1993) Interleukin-10-de-ficient mice develop chronic enterocolitis._Cell_75, 263–274.
    Article CAS PubMed Google Scholar
59. Maggio-Price, L., Treuting, P., Zeng, W., Tsang, M., Bielefeldt-Ohmann, H., and Iritani, B. M. (2006)_Helicobacter_infection is required for inflammation and colon cancer in SMAD3-defi-cient mice._Cancer Res_66, 828–838.
    Article CAS PubMed Google Scholar
60. Baumgart, D. C., Olivier, W. A., Reya, T., Peritt, D., Rombeau, J. L., and Carding, S. R. (1998) Mechanisms of intestinal epithelial cell injury and colitis in interleukin 2 (IL2)-deficient mice._Cell Immunol_187, 52–66.
    Article CAS PubMed Google Scholar
61. Mombaerts, P., Mizoguchi, E., Grusby, M. J., Glimcher, L. H., Bhan, A. K., and Ton-egawa, S. (1993) Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice._Cell_75, 274–282.
    Article CAS PubMed Google Scholar
62. Rudolph, U., Finegold, M. J., Rich, S. S., Har-riman, G. R., Srinivasan, Y., Brabet, P., et al. (1995) Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice._Nat Genet_10, 143–150.
    Article CAS PubMed Google Scholar
63. Engle, S. J., Ormsby, I., Pawlowski, S., Boivin, G. P., Croft, J., Balish, E., et al. (2002) Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice._Cancer Res_62, 6362–6366.
    CAS PubMed Google Scholar
64. Maggio-Price, L., Bielefeldt-Ohmann, H., Treuting, P., Iritani, B. M., Zeng, W., Nicks, A., et al. (2005) Dual infection with_Heli-cobacter bilis_and_Helicobacter hepaticus_in p-glycoprotein-deficient mdr1a−/−mice results in colitis that progresses to dysplasia._Am J Pathol_166, 1793–1806.
    Article CAS PubMed Google Scholar
65. Erdman, S. E., Poutahidis, T., Tomczak, M., Rogers, A. B., Cormier, K., Plank, B., et al. (2003) CD4(+) CD25(+) regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice._Am J Pathol_162, 691–702.
    Article CAS PubMed Google Scholar
66. Berg, D. J., Davidson, N., Kuhn, R., Muller, W., Menon, S., Holland, G., et al. (1996) Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses._J Clin Invest_98, 1010–1020.
    Article CAS PubMed Google Scholar
67. Erdman, S. E., Rao, V. P., Poutahidis, T., Ihrig, M. M., Ge, Z., Feng, Y., et al. (2003) CD4(+) CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogen-esis in mice._Cancer Res_63, 6042–6050.
    CAS PubMed Google Scholar
68. Itzkowitz, S. H. and Yio, X. (2004) Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation._Am J Physiol Gastrointest Liver Physiol_287, G7–17.
    Article CAS PubMed Google Scholar
69. Winawer, S. J., Zauber, A. G., Fletcher, R. H., Stillman, J. S., O'Brien, M. J., Levin, B., et al. (2006) Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society._Gas-troenterology_130, 1872–1885.
    Article Google Scholar
70. Mast, E. E., Alter, M. J., and Margolis, H. S. (1999) Strategies to prevent and control_Hepatitis B_and_C_virus infections: a global perspective._Vaccine_17, 1730–1733.
    Article CAS PubMed Google Scholar
71. Dandri, M., Lutgehetmann, M., Volz, T., and Petersen, J. (2006) Small animal model systems for studying_Hepatitis B_virus replication and pathogenesis._Semin Liver Dis_26, 181–191.
    Article CAS PubMed Google Scholar
72. Perz, J. F., Armstrong, G. L., Farrington, L. A., Hutin, Y. J., and Bell, B. P. (2006) The contributions of_Hepatitis B_virus and_Hepatitis C_virus infections to cirrhosis and primary liver cancer worldwide._J Hepatol_45, 529–538.
    Article PubMed Google Scholar
73. El-Serag, H. B. and Rudolph, K. L. (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis._Gastroenterology_132, 2557–2576.
    Article CAS PubMed Google Scholar
74. Chaimuangraj, S., Thamavit, W., Tsuda, H., and Moore, M. A. (2003) Experimental investigation of opisthorchiasis-associated cholan-giocarcinoma induction in the Syrian hamster – pointers for control of the human disease._Asian Pac J Cancer Prev_4, 87–93.
    PubMed Google Scholar
75. Fox, J. G., Dewhirst, F. E., Tully, J. G., Paster, B. J., Yan, L., Taylor, N. S., et al. (1994)_Heli-cobacter hepaticus_sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice._J Clin Microbiol_32, 1238–1245.
    CAS PubMed Google Scholar
76. Ward, J. M., Fox, J. G., Anver, M. R., Haines, D. C., George, C. V., Collins, M. J., Jr., et al. (1994) Chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel_Helicobacter_species._J Natl Cancer Inst_86, 1222–1227.
    Article CAS PubMed Google Scholar
77. Ward, J. M., Anver, M. R., Haines, D. C., and Benveniste, R. E. (1994) Chronic active hepatitis in mice caused by_Helicobacter hepaticus_._Am J Pathol_145, 959–968.
    CAS PubMed Google Scholar
78. Canella, K. A., Diwan, B. A., Gorelick, P. L., Donovan, P. J., Sipowicz, M. A., Kasprzak, K. S., et al. (1996) Liver tumorigenesis by_Helico-bacter hepaticus_: considerations of mechanism._In Vivo_10, 285–292.
    CAS PubMed Google Scholar
79. Leong, R. W. and Sung, J. J. (2002) Review article:_Helicobacter_species and hepatobiliary diseases._Aliment Pharmacol Ther_16, 1037–1045.
    Article CAS PubMed Google Scholar
80. Whary, M. T. and Fox, J. G. (2006) Detection, eradication, and research implications of_Helicobacter_infections in laboratory rodents._Lab Anim (NY)_35, 25–27, 30–26.
    Article Google Scholar
81. Nyska, A., Maronpot, R. R., Eldridge, S. R., Haseman, J. K., and Hailey, J. R. (1997) Alteration in cell kinetics in control B6C3F1 mice infected with_Helicobacter hepaticus_._Tox-icol Pathol_25, 591–596.
    Article CAS Google Scholar
82. Hailey, J. R., Haseman, J. K., Bucher, J. R., Radovsky, A. E., Malarkey, D. E., Miller, R. T., et al. (1998) Impact of_Helicobacter hepaticus_infection in B6C3F1 mice from twelve National Toxicology Program two-year carcinogenesis studies._Toxicol Pathol_26, 602–611.
    CAS PubMed Google Scholar
83. Ihrig, M., Schrenzel, M. D., and Fox, J. G. (1999) Differential susceptibility to hepatic inflammation and proliferation in AXB recombinant inbred mice chronically infected with_Helicobacter hepaticus_._Am J Pathol_155, 571–582.
    Article CAS PubMed Google Scholar
84. Singh, R., Leuratti, C., Josyula, S., Sipowicz, M. A., Diwan, B. A., Kasprzak, K. S., et al. (2001) Lobe-specific increases in malondial-dehyde DNA adduct formation in the livers of mice following infection with_Helicobacter hepaticus_._Carcinogenesis_22, 1281–1287.
    Article CAS PubMed Google Scholar
85. Sipowicz, M. A., Chomarat, P., Diwan, B. A., Anver, M. A., Awasthi, Y. C., Ward, J. M., et al. (1997) Increased oxidative DNA damage and hepatocyte overexpression of specific cytochrome P450 isoforms in hepatitis of mice infected with_Helicobacter hepaticus_._Am J Pathol_151, 933–941.
    CAS PubMed Google Scholar
86. Sipowicz, M. A., Weghorst, C. M., Shiao, Y. H., Buzard, G. S., Calvert, R. J., Anver, M. R., et al. (1997) Lack of p53 and ras mutations in_Helicobacter hepaticus_-induced liver tumors in A/JCr mice._Carcinogenesis_18, 233–236.
    Article CAS PubMed Google Scholar
87. Ramljak, D., Jones, A. B., Diwan, B. A., Per-antoni, A. O., Hochadel, J. F., and Anderson, L. M. (1998) Epidermal growth factor and transforming growth factor-alpha-associated overexpression of cyclin D1, Cdk4, and c-Myc during hepatocarcinogenesis in_Helicobacter hepaticus_-infected A/JCr mice._Cancer Res_58, 3590–3597.
    CAS PubMed Google Scholar
88. Diwan, B. A., Ward, J. M., Ramljak, D., and Anderson, L. M. (1997) Promotion by_Heli-cobacter hepaticus_-induced hepatitis of hepatic tumors initiated by_N_-nitrosodimethylamine in male A/JCr mice._Toxicol Pathol_25, 597–605.
    Article CAS PubMed Google Scholar
89. Ward, J. M. (1997) Helicobacter infections of rodents and carcinogenesis bioassays._Toxicol Pathol_25, 590.
    Article CAS PubMed Google Scholar
90. Fox, J. G., MacGregor, J. A., Shen, Z., Li, X., Lewis, R., and Dangler, C. A. (1998) Comparison of methods of identifying_Helicobacter hepaticus_in B6C3F1 mice used in a carcinogen-esis bioassay._J Clin Microbiol_36, 1382–1387.
    CAS PubMed Google Scholar
91. Haseman, J. K., Hailey, J. R., and Morris, R. W. (1998) Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F1 mice in two-year carcinogenicity studies: a National Toxicology Program update._Toxicol Pathol_26, 428–441.
    Article CAS PubMed Google Scholar
92. Waxman, D. J. and O×Connor, C. (2006) Growth hormone regulation of sex-dependent liver gene expression._Mol Endocrinol_20, 2613–2629.
    Article CAS PubMed Google Scholar
93. Boutin, S. R., Rogers, A. B., Shen, Z., Fry, R. C., Love, J. A., Nambiar, P. R., et al. (2004) Hepatic temporal gene expression profiling in_Helicobacter hepaticus_-infected A/JCr mice._Toxicol Pathol_32, 678–693.
    Article PubMed Google Scholar
94. Rogers, A. B., Boutin, S. R., Whary, M. T., Sundina, N., Ge, Z., Cormier, K., et al. (2004) Progression of chronic hepatitis and preneoplasia in_Helicobacter hepaticus_-infected A/JCr mice._Toxicol Pathol_32, 668–677.
    Article PubMed Google Scholar
95. O'Rourke, J. L., Grehan, M., and Lee, A. (2001) Non-pylori Helicobacter species in humans._Gut_49, 601–606.
    Article PubMed Google Scholar
96. Fox, J. (1998) Enterohepatic_Helicobacters_: natural and experimental models._Ital J Gas-troenterol Hepatol_30(3), S264–269.
    Google Scholar
97. Maurer, K. J., Rogers, A. B., Ge, Z., Wiese, A. J., Carey, M. C., and Fox, J. G. (2006)_Heli-cobacter pylori_and cholesterol gallstone formation in C57L/J mice: a prospective study._Am J Physiol Gastrointest Liver Physiol_290, G175–182.
    Article CAS PubMed Google Scholar

Download references