Structure, function and regulation of mammalian DNA methyltransferase (original) (raw)
References
Adams, R. L., Burdon, R. H., McKinnon, K., and Rinaldi, A. (1983) Stimulation of de novo methylation following limited proteolysis of mouse ascites DNA methylase. FEBS Lett. 163, 194–198. ArticlePubMedCAS Google Scholar
Adams, R. L. P., Bryans, M., Rinaldi, A., Smart, A., and Yesufu, H. M. I. (1990) Eukaryotic DNA methylases and their use for in vitro methylation. Phil. Trans. R. Soc. Lond. B 326, 11–21. Article Google Scholar
Antequera, F., Boyes, J., and Bird, A. (1990) High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell 62, 503–14. ArticlePubMedCAS Google Scholar
Antequera, F., Macleod, D., and Bird, A. P. (1989) Specific protection of methylated CpGs in mammalian nuclei. Cell 58, 509–517. ArticlePubMedCAS Google Scholar
Bestor, T. (1990) DNA methylation: evolution of a bacterial immune function into a regulator of gene expression and genome structure in higher eukaryotes. Phil. Trans. R. Soc. Lond. B 326, 179–187. ArticleCAS Google Scholar
Bestor, T. (1992) Activation of mammalian DNA methyltransferase by cleavage of a Zinc-binding regulatory domain. EMBO J., 11, 2611–2617. PubMedCAS Google Scholar
Bestor, T., Hellewell, S. B., and Ingram, V. M. (1984) Differentiation of two mouse cell lines is accompanied by demethylation of their genomes. Mol. Cell. Biol. 4, 1800–1806. PubMedCAS Google Scholar
Bestor, T., Laudano, A., Mattaliano, R., and Ingram, V. (1988) Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J. Mol. Biol. 203, 971–83. ArticlePubMedCAS Google Scholar
Bestor, T. H., and Ingram, V. M. (1983) Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA. Proc. Natl. Acad. Sci. USA_80_, 5559–63. ArticlePubMedCAS Google Scholar
Bestor, T. H., and Ingram, V. M. (1985) Growth-dependent expression of multiple species of DNA methyltransferase in murine erythroleukemia cells. Proc. Natl. Acad. Sci. USA 82, 2674–8. ArticlePubMedCAS Google Scholar
Bolden, A., Ward, C., Siedlecki, J. A., and Weissbach, A. (1984) DNA methylation. Inhibition of de novo and maintenance methylation in vitro by RNA and synthetic polynucleotides. J. Biol. Chem. 259, 12437–43. PubMedCAS Google Scholar
Chaillet, J. R., Vogt, T. F., Beier, D. R., and Leder, P. (1991) Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis. Cell 66, 77–83. ArticlePubMedCAS Google Scholar
Chen, L., MacMillan, A. M., Chang, W., Ezaz, N. K., Lane, W. S., and Verdine, G. L. (1991) Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase. Biochemistry 30, 11018–25. ArticlePubMedCAS Google Scholar
Czank, A., Hàuselman, R., Page, A. W., Leonhardt, H., Bestor, T. H, Schaffner, W., and Hergersberg, M. (1991) Expression in mammalian cells of a cloned gene encoding murine DNA methyltransferase. Gene 109, 259–263. ArticlePubMedCAS Google Scholar
Engler, P., Haasch, D., Pinkert, C. A., Doglio, L., Glymour, M., Brinster, R., and Storb, U. (1991) A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci. Cell 65, 939–947. ArticlePubMedCAS Google Scholar
Flatau, E., Gonzales, F. A., Michalowsky, L. A., and Jones, P. A. (1984) DNA methylation in 5-aza-2’-deoxycytidine-resistant variants of C3H 10T1/2 CI8 cells. Mol. Cell. Biol. 4, 2098–102. PubMedCAS Google Scholar
Fox, K. R. (1986) The effect of Hhal methylation on DNA local structure. Biochem. J. 234, 213–216. PubMedCAS Google Scholar
Gruenbaum, Y., Stein, R., Cedar, H., and Razin, A. (1981) Methylation of CpG sequences in eukaryotic DNA. FEBS Lett. 124, 67–71. ArticlePubMedCAS Google Scholar
Gruenbaum, Y., Cedar, H., and Razin, A. (1982) Substrate and sequence specificity of a eukaryotic DNA methylase. Nature 295, 620–622. ArticlePubMedCAS Google Scholar
Holliday, R., and Pugh, J. (1975) DNA modification mechanisms and gene activity during development. Science 187, 226–232. ArticlePubMedCAS Google Scholar
Howlett, S. K., and Reik, W. (1991) Methylation levels of maternal and paternal genomes during preimplantation development. Development 113, 119–127. PubMedCAS Google Scholar
Hubrich, K. K., Buhk, H. J., Wagner, H., Kroger, H., and Simon, D. (1989) Non-C-G recognition sequences of DNA cytosine-5-methyltransferase from rat liver. Biochem. Biophys. Res. Commun. 160., 1175–1182. Google Scholar
Ingrosso, D., Fowler, A. V., Bleibaum, J., and Clarke, S. (1989) Sequence of the D-aspartyl/L- isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltrans- ferases. J. Biol. Chem. 264., 20131–20139. Google Scholar
Klimasauskas, S., Nelson, J. L., and Roberts, R. J. (1991) The methylase specificity domain of cytosine C5 methylases. Nucl. Acids Res. 19; 6183–6190. ArticlePubMedCAS Google Scholar
Jahner, D., and Jaenisch, R. (1985) Chromosomal position and specific demethylation in enhancer sequences of germ line-transmitted retroviral genomes during mouse development. Mol. Cell. Biol. 5, 2212–2220. PubMedCAS Google Scholar
Jost, J.-P., Saluz, H.-P., McEwan, I., Feavers, I. M., Hughes, M., Reiber, S., Liang, H. M., and Vaccaro, M. (1990) Tissue specific expression of avian vitellogenin gene is correlated with DNA hypomethylation and in vivo specific protein-DNA interactions. Phil. Trans. Roy. Soc. Lond. B 326, 53–63. Article Google Scholar
Lahm, A., and Suck, D. (1991) DNase I-induced DNA conformation. J. Mol. Biol. 221, 645–667. Article Google Scholar
Lange, C., Jugel, A., Walter, J., Noyer, W. M., and Trautner, T. A. (1991) ‘Pseudo’ domains in phage-encoded DNA methyltransferases. Nature 352, 645–648. Google Scholar
Lauster, R., Trautner, T. A., and Noyer-Weidner, M. (1989) Cytosine-specific type II DNA methyltransferases. A conserved enzyme core with variable target-recognizing domains. J. Mol. Biol. 206., 305–312. Google Scholar
Li, E., Bestor, T. H., and Jaenisch, R. (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915–926. ArticlePubMedCAS Google Scholar
Mansour, S. L., Thomas, K. R., and Capecchi, M. R. (1988) Disruption of the protooncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336, 348–352. ArticlePubMedCAS Google Scholar
Meehan, R. R., Lewis, J. D., McKay, S., Kleiner, E. L., and Bird, A. P. (1989) Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs. Cell 58, 499–507. ArticlePubMedCAS Google Scholar
Monk, M. (1990). Changes in DNA methylation during mouse embryonic development in relation to X-chromosome activity and imprinting. Phil. Trans. Roy. Soc. Lond. B. 326, 179–187. Article Google Scholar
Monk, M., Boubelik, M., and Lehnert, S. (1987) Temporal and regional changes in DNA methylation in the embryonic, extraembryonic, and germ cell lineages during mouse embryo development. Development 99; 371–382. PubMedCAS Google Scholar
Pfeifer, G. P., and Drahovsky, D. (1986) DNA methyltransferase polypeptides in mouse and human cells. Biochim. Biophys. Acta 868, 238–242. CAS Google Scholar
Pfeifer, G. P., Grunwald, S., Palitti, F., Kaul, S., Boehm, T. L., Hirth, H. P., and Drahovsky, D. (1985) Purification and characterization of mammalian DNA methyltransferases by use of monoclonal antibodies. J. Biol. Chem. 260, 13787–13793. PubMedCAS Google Scholar
Pfeifer, G. P., Grunwald, S., Boehm, T. L., and Drahovsky, D. (1983) Isolation and characterization of DNA cytosine 5-methyltransferase from human placenta. Biochim. Biophys. Acta 740, 323–330. PubMedCAS Google Scholar
Posfai, J., Bhagwat, A. S., Posfai, G., and Roberts, R. J. (1989) Predictive motifs derived from cytosine methyltransferases. Nucl. Acids Res. 17, 2421–2435. ArticlePubMedCAS Google Scholar
Renbaum, P., Abrahamove, D., Fainsod, A., Wilson, G. G., Rottem, S., and Razin, A. (1990) Cloning, characterization, and expression in Escherichia coli of the gene coding for the CpG DNA methylase from Spiroplasma sp. strain MQ1 (M. Sssl). Nucl. Acids Res. 18, 1145–1152. ArticlePubMedCAS Google Scholar
Riggs, A. D. (1975) X inactivation, differentiation, and DNA methylation. Cytogenet. Cell Genet. 14, 9–25. ArticleCAS Google Scholar
Santi, D. V., Garrett, C. E., and Barr, P. J. (1983) On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs. Cell 33, 9–10. ArticlePubMedCAS Google Scholar
Simon, D., Stuhlmann, H., Jahner, D., Wagner, H., Werner, E., and Jaenisch, R. (1983) Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infec- tious. Nature 304, 275–277. ArticlePubMedCAS Google Scholar
Schwartz, M. N., Trautner, T. A., and Kornberg, A. (1962) Enzymatic synthesis of DNA. J. Biol. Chem. 237, 1961–1967. Google Scholar
Sznyter, L. A., Slatko, B., Moran, L., O’Donnell, K. H., and Brooks, J. E. (1987) Nucleotide sequence of the Ddel restriction-modification system and characterization of the methylase protein. Nucl. Acids Res. 15, 1846–1866. Article Google Scholar
Uehara, Y., Ono, T., Kurishita, A., Kokuryu, H., and Okada, S. (1989) Age-dependent and tissue-specific changes of DNA methylation within and around the c-fos gene in mice. Oncogene 4, 1023–1028. PubMedCAS Google Scholar
Wu, J. C., and Santi, D. V. (1987) Kinetic and catalytic mechanism of Hhal methyltrans- ferase. J. Biol. Chem. 262, 4778–4786. PubMedCAS Google Scholar
Zucker, K. E., Riggs, A. D., and Smith, S. S. (1985) Purification of human DNA (cytosine-5)- methyltransferase. J. Cell. Biochem. 29, 337–349. ArticlePubMedCAS Google Scholar