TRPM2 (original) (raw)

• Ame JC, Spenlehauer C, de Murcia G (2004) The PARP superfamily. Bioessays 26:882–893
  Article CAS PubMed Google Scholar
• Becker D, Blase C, Bereiter-Hahn J, et al (2005) TRPV4 exhibits a functional role in cell-volume regulation. J Cell Sci 118:2435–2440
  Article CAS PubMed Google Scholar
• Bessman MJ, Frick DN, O’Handley SF (1996) The MutT proteins or “Nudix” hydrolases, a family of versatile, widely distributed, “housecleaning” enzymes. J Biol Chem 271: 25059–25062
  Article CAS PubMed Google Scholar
• Bessman MJ, Walsh JD, Dunn CA, et al (2001) The geneygdP, associated with the invasiveness of Escherichia coli K1, designates a Nudix hydrolase, Orf176, active on adenosine (5′)-pentaphospho-(5′)-adenosine (Ap5A). J Biol Chem 276:37834–37838
  CAS PubMed Google Scholar
• Cahalan MD (2001) Cell biology. Channels as enzymes. Nature 411:542–543
  Article CAS PubMed Google Scholar
• Chen Q, Olney JW, Lukasiewicz PD, et al (1998) Fenamates protect neurons against ischemic and excitotoxic injury in chick embryo retina. Neurosci Lett 242:163–166
  Article CAS PubMed Google Scholar
• Duncan LM, Deeds J, Hunter J, et al (1998) Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res 58:1515–1520
  CAS PubMed Google Scholar
• Dunn CA, O’Handley SF, Frick DN, et al (1999) Studies on the ADP-ribose pyrophosphatase subfamily of the nudix hydrolases and tentative identification of trgB, a gene associated with tellurite resistance. J Biol Chem 274:32318–32324
  Article CAS PubMed Google Scholar
• Dunn JS, Sheehan HL, McLetchie NGB (1943) Necrosis of islets of Langerhans. Lancet 1:484–487
  Google Scholar
• Dzeja C, Hagen V, Kaupp UB, et al (1999) Ca2+ permeation in cyclic nucleotide-gated channels. EMBO J 18:131–144
  Article CAS PubMed Google Scholar
• Elsner M, Tiedge M, Guldbakke B, et al (2002) Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan. Diabetologia 45:1542–1549
  Article CAS PubMed Google Scholar
• Fonfria E, Marshall IC, Benham CD, et al (2004) TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase. Br J Pharmacol 143:186–192
  Article CAS PubMed Google Scholar
• Fonfria E, Marshall IC, Boyfield I, et al (2005) Amyloid beta-peptide(1–42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures. J Neurochem 95:715–723
  Article CAS PubMed Google Scholar
• Frings S, Seifert R, Godde M, et al (1995) Profoundly different calcium permeation and blockage determine the specific function of distinct cyclic nucleotide-gated channels. Neuron 15:169–179
  Article CAS PubMed Google Scholar
• Gasser A, Guse AH (2005) Determination of intracellular concentrations of the TRPM2 agonist ADP-ribose by reversed-phase HPLC. J Chromatogr B Analyt Technol Biomed Life Sci 821:181–187
  CAS PubMed Google Scholar
• Gasser A, Glassmeier G, Fliegert R, et al (2006) Activation of T cell calcium influx by the second messenger ADP-ribose. J Biol Chem 281:2489–2496
  Article CAS PubMed Google Scholar
• Guse HA (2000) Cyclic ADP-ribose. J Mol Med 78:26–35
  Article CAS PubMed Google Scholar
• Halaszovich CR, Zitt C, Jüngling E, et al (2000) Inhibition of TRP3 channels by lanthanides. Block from the cytosolic side of the plasma membrane. J Biol Chem 275:37423–37428
  Article CAS PubMed Google Scholar
• Hara Y, Wakamori M, Ishii M, et al (2002) LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9:163–173
  Article CAS PubMed Google Scholar
• Harteneck C (2005) Function and pharmacology of TRPM cation channels. Naunyn Schmiedebergs Arch Pharmacol 371:307–314
  Article CAS PubMed Google Scholar
• Heiner I, Eisfeld J, Halaszovich CR, et al (2003) Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD. Biochem J 371:1045–1053
  Article CAS PubMed Google Scholar
• Heiner I, Radukina N, Eisfeld J, et al (2005) Regulation of TRPM2 channels in neutrophil granulocytes by ADP-ribose: a promising pharmacological target. Naunyn Schmiedebergs Arch Pharmacol 371:325–333
  Article CAS PubMed Google Scholar
• Heiner I, Eisfeld J, Warnstedt M, et al (2006) Endogenous ADP-ribose enables calcium-regulated cation currents through TRPM2 channels in neutrophil granulocytes. Biochem J 398:225–232
  Article CAS PubMed Google Scholar
• Herson PS, Ashford ML (1997) Activation of a novel non-selective cation channel by alloxan and H2O2 in the rat insulin-secreting cell line CRI-G1. J Physiol 501:59–66
  Article CAS PubMed Google Scholar
• Herson PS, Lee K, Pinnock RD, et al (1999) Hydrogen peroxide induces intracellular calcium overload by activation of a non-selective cation channel in an insulin-secreting cell line. J Biol Chem 274:833–841
  Article CAS PubMed Google Scholar
• Hill K, Benham CD, McNulty S, et al (2004a) Flufenamic acid is a pH-dependent antagonist of TRPM2 channels. Neuropharmacology 47:450–460
  Article CAS PubMed Google Scholar
• Hill K, McNulty S, Randall AD (2004b) Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole. Naunyn Schmiedebergs Arch Pharmacol 370:227–237
  Article CAS PubMed Google Scholar
• Howard M, Grimaldi JC, Bazan JF, et al (1993) Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. Science 262:1056–1059
  Article CAS PubMed Google Scholar
• im Walde SS, Dohle C, Schott-Ohly P, et al (2002) Molecular target structures in alloxan-induced diabetes in mice. Life Sci 71:1681–1694
  Article PubMed Google Scholar
• Inamura K, Sano Y, Mochizuki S, et al (2003) Response to ADP-ribose by activation of TRPM2 in the CRI-G1 insulinoma cell line. J Membr Biol 191:201–207
  Article CAS PubMed Google Scholar
• Inoue R, Okada T, Onoue H, et al (2001) The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. Circ Res 88:325–332
  CAS PubMed Google Scholar
• Jensen BS, Strobaek D, Christophersen P, et al (1998) Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel. Am J Physiol 275:C848–C856
  CAS PubMed Google Scholar
• Kim SJ, Shin SY, Lee JE, et al (2003) Ca2+-activated Cl− channel currents in rat ventral prostate epithelial cells. Prostate 55:118–127
  Article CAS PubMed Google Scholar
• Kim UH, Kim MK, Kim JS, et al (1993) Purification and characterization of NAD glycohydrolase from rabbit erythrocytes. Arch Biochem Biophys 305:147–152
  Article CAS PubMed Google Scholar
• Kolisek M, Beck A, Fleig A, et al (2005) Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. Mol Cell 18:61–69
  Article CAS PubMed Google Scholar
• Kraft R, Grimm C, Grosse K, et al (2004) Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Am J Physiol Cell Physiol 286:C129–C137
  Article CAS PubMed Google Scholar
• Krause KH, Campbell KP, Welsh MJ, et al (1990) The calcium signal and neutrophil activation. Clin Biochem 23:159–166
  Article CAS PubMed Google Scholar
• Kühn FJ, Lückhoff A (2004) Sites of the NUDT9-H domain critical for ADP-ribose activation of the cation channel TRPM2. J Biol Chem 279:46431–46437
  Article PubMed Google Scholar
• Lee HM, Kim HI, Shin YK, et al (2003a) Diclofenac inhibition of sodium currents in rat dorsal root ganglion neurons. Brain Res 992:120–127
  Article CAS PubMed Google Scholar
• Lee N, Chen J, Sun L, et al (2003b) Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3). J Biol Chem 278:20890–20897
  Article CAS PubMed Google Scholar
• Lee YM, Kim BJ, Kim HJ, et al (2003c) TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach. Am J Physiol Gastrointest Liver Physiol 284:G604–G616
  CAS PubMed Google Scholar
• Lee YT, Wang Q (1999) Inhibition of hKv2.1, a major human neuronal voltage-gated K+ channel, by meclofenamic acid. Eur J Pharmacol 378:349–356
  Article CAS PubMed Google Scholar
• Levitan IB, Cibulsky SM (2001) Biochemistry. TRP ion channels—two proteins in one. Science 293:1270–1271
  Article CAS PubMed Google Scholar
• Li PL, Zhang DX, Ge ZD, et al (2002) Role of ADP-ribose in 11,12-EET-induced activation of KCa channels in coronary arterial smooth muscle cells. Am J Physiol Heart Circ Physiol 282:H1229–H1236
  CAS PubMed Google Scholar
• McHugh D, Flemming R, Xu SZ, et al (2003) Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation. J Biol Chem 278:11002–11006
  Article CAS PubMed Google Scholar
• McNulty S, Fonfria E (2005) The role of TRPM channels in cell death. Pflugers Arch 451:235–242
  Article CAS PubMed Google Scholar
• McQuillin A, Bass NJ, Kalsi G, et al (2006) Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3. Mol Psychiatry 11:134–142
  Article CAS PubMed Google Scholar
• Mehta K, Shahid U, Malavasi F (1996) Human CD38, a cell-surface protein with multiple functions. FASEB J 10:1408–1417
  CAS PubMed Google Scholar
• Miller BA (2004) Inhibition of TRPM2 function by PARP inhibitors protects cells from oxidative stress-induced death. Br J Pharmacol 143:515–516
  Article CAS PubMed Google Scholar
• Nagamine K, Kudoh J, Minoshima S, et al (1998) Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain. Genomics 54:124–131
  Article CAS PubMed Google Scholar
• Partida-Sanchez S, Cockayne DA, Monard S, et al (2001) Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo. Nat Med 7:1209–1216
  Article CAS PubMed Google Scholar
• Peier AM, Moqrich A, Hergarden AC, et al (2002) A TRP channel that senses cold stimuli and menthol. Cell 108:705–715
  Article CAS PubMed Google Scholar
• Perraud AL, Fleig A, Dunn CA, et al (2001) ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 411:595–599
  Article CAS PubMed Google Scholar
• Perraud AL, Shen B, Dunn CA, et al (2003) NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. J Biol Chem 278:1794–1801
  Article CAS PubMed Google Scholar
• Pfister M, Ogilvie A, da Silva CP, et al (2001) NAD degradation and regulation of CD38 expression by human monocytes/macrophages. Eur J Biochem 268:5601–5608
  Article CAS PubMed Google Scholar
• Qian F, Huang P, Ma L, et al (2002) TRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells. Diabetes 51Suppl 1:S183–S189
  CAS PubMed Google Scholar
• Ruf A, de Murcia G, Schulz GE (1998) Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling. Biochemistry 37:3893–3900
  Article CAS PubMed Google Scholar
• Runnels LW, Yue L, Clapham DE (2001) TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science 291:1043–1047
  Article CAS PubMed Google Scholar
• Sano Y, Inamura K, Miyake A, et al (2001) Immunocyte Ca2+ influx system mediated by LTRPC2. Science 293:1327–1330
  Article CAS PubMed Google Scholar
• Scharenberg AM (2005) TRPM2 and TRPM7: channel/enzyme fusions to generate novel intracellular sensors. Pflugers Arch 451:220–227
  Article CAS PubMed Google Scholar
• Schuber F, Lund FE (2004) Structure and enzymology of ADP-ribosyl cyclases: conserved enzymes that produce multiple calcium mobilizing metabolites. Curr Mol Med 4:249–261
  Article CAS PubMed Google Scholar
• Shen BW, Perraud AL, Scharenberg A, et al (2003) The crystal structure and mutational analysis of human NUDT9. J Mol Biol 332:385–398
  Article CAS PubMed Google Scholar
• Smith MA, Herson PS, Lee K, et al (2003) Hydrogen-peroxide-induced toxicity of rat striatal neurones involves activation of non-selective cation channel. J Physiol (Lond) 547:417–425
  Article CAS PubMed Google Scholar
• Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, Tominaga M (2006) TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J 25:1804–1815
  Article CAS PubMed Google Scholar
• Tousova K, Vyklicky L, Susankova K, et al (2005) Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites. Mol Cell Neurosci 30:207–217
  Article CAS PubMed Google Scholar
• Tsavaler L, Shapero MH, Morkowski S, et al (2001) Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res 61:3760–3769
  CAS PubMed Google Scholar
• Uemura T, Kudoh J, Noda S, et al (2005) Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum. Biochem Biophys Res Commun 328:1232–1243
  Article CAS PubMed Google Scholar
• Ullrich ND, Voets T, Prenen J, et al (2005) Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 frommice. Cell Calcium 37:267–278
  Article CAS PubMed Google Scholar
• Wehage E, Eisfeld J, Heiner I, et al (2002) Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose. J Biol Chem 277:23150–23156
  Article CAS PubMed Google Scholar
• Xu C, Macciardi F, Li PP, et al (2006) Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 141:36–43
  PubMed Google Scholar
• Yang KT, Chang WL, Yang PC, et al (2006) Activation of the transient receptor potential M2 channel and poly(ADP-ribose) polymerase is involved in oxidative stress-induced cardiomyocyte death. Cell Death Differ 13:1815–1826
  Article CAS PubMed Google Scholar
• Yost DA, Anderson BM (1981) Purification and properties of the soluble NAD glycohydrolase from Bungarus fasciatus venom. J Biol Chem 256:3647–3653
  CAS PubMed Google Scholar
• Zhang W, Chu X, Tong Q, et al (2003) A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. J Biol Chem 278:16222–16229
  Article CAS PubMed Google Scholar
• Zhang W, Hirschler-Laszkiewicz I, Tong Q, et al (2006) TRPM2 is an ion channel which modulates hematopoietic cell death through activation of caspases and PARP cleavage. Am J Physiol Cell Physiol 290:C1146–C1159
  Article CAS PubMed Google Scholar