Cell Type-Specific Signaling in Response to Interferon-γ (original) (raw)

Abstract

Type II interferon-γ (IFN-γ) is a pleiotropic cytokine that regulates many different cellular functions. The major signaling pathway activated by IFN-γ involves sequential phosphorylation of the tyrosine residues of the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) proteins, providing the primary mechanism through which gene expression is induced. However, recent work has revealed that the responses are complex, as shown by the activation of kinases in addition to JAKs, differential patterns of activation of STAT1, STAT3, and STAT5 in different cells, and activation of transcription factors other than STATs. This complexity is used to regulate biological functions differentially in a cell type-specific manner, by activating different specific signals and patterns of gene expression.

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Authors and Affiliations

  1. Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA
    A. H. H. van Boxel-Dezaire & G. R. Stark

Authors

  1. A. H. H. van Boxel-Dezaire
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  2. G. R. Stark
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Editors and Affiliations

  1. The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, 1650 Orleans Street, Baltimore, MD, 21231, USA
    Paula M. Pitha

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© 2007 Springer-Verlag Berlin Heidelberg

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van Boxel-Dezaire, A., Stark, G.R. (2007). Cell Type-Specific Signaling in Response to Interferon-γ. In: Pitha, P.M. (eds) Interferon: The 50th Anniversary. Current Topics in Microbiology and Immunology, vol 316. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71329-6\_7

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