Disruption of a Homolog of Trithorax by 11q23 Translocations: Leukemogenic and Transcriptional Implications (original) (raw)

References

• Aasland R, Gibson TJ, Stewart AF (1995) The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem Sci 20: 56 – 59
  PubMed CAS Google Scholar
• Alkema MJ, van der Lugt NMT, Bobeldijk RC, Berns A, van Lohuizen M (1995) Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice. Nature 374: 724 – 727
  PubMed CAS Google Scholar
• Bestor TH (1992) Activation of mammalian DNA methyltransferase by cleavage of a ZN binding regulatory domains. EMBO J 11: 2611 – 2617
  PubMed CAS Google Scholar
• Bestor T, Laudano A, Mattaliano R, Ingram V (1988) Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxy-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J Mol Biol 203: 971 – 983
  PubMed CAS Google Scholar
• Bestor TH, Verdine GL (1994) DNA methyltransferases. Curr Biol 6: 380 – 389
  CAS Google Scholar
• Bernard OA, Mauchauffe M, Mecucci C, Van den Berghe H, Berger R (1994) A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL. Oncogene 9: 1039 – 1045
  PubMed CAS Google Scholar
• Biggin M, Tijan R (1988) Transcription factors that activate the Ultrabithorax promoter in developmentally staged extracts. Cell 53: 699 – 711
  PubMed CAS Google Scholar
• Borkhardt A, Repp R, Haupt E, Brettreich S, Buchen U, Gossen R, Lampert F (1994) Molecular analysis of MLL-1/AF4 recombination in infant acute lymphoblastic leukemia. Leukemia 8: 549 – 553
  PubMed CAS Google Scholar
• Bower M, Parry P, Carter M, Lillington DM, Amess J, Lister TA, Evans G, Young BD (1994a) Prevalence and clinical correlations of MLL gene rearrangements in AML-M4/5. Blood 84: 3776 – 3780
  CAS Google Scholar
• Bower M, Parry P, Gibbons B, Amess J, Lister TA, Young BD, Evans GA (1994b) Human trithorax gene rearrangements in therapy-related acute leukaemia after etoposide treatment. Leukemia 8: 226 – 229
  CAS Google Scholar
• Breen TR, Harte PJ (1991) Molecular characterization of the trithorax gene, a positive regulator of horneo tic gene expression in Drosophila. Mech Dev 35: 113 – 127
  PubMed CAS Google Scholar
• Breen TR, Harte PJ (1993) trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each. Development 117: 119–134
  Google Scholar
• Broeker PL, Gill Super H, Thirman MJ, Pomykala H, Yuka Y, Tanabe S, Zeleznik-Le N, Rowley J (1994) Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites. Blood 87: 1912 – 1922
  Google Scholar
• Broeker PL, Gill Super H, Thirman MJ, Pomykala H, Yuka Y, Tanabe S, Zeleznik-Le N, Rowley J (1994) Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites. Blood 87: 1912 – 1922
  Google Scholar
• Brunk BP, Martin EC, Adler PN (1991) Drosophila genes Posterior sex combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene. Nature 353: 351 – 353
  PubMed CAS Google Scholar
• Cairns BR, Kim YJ, Sayre MH, Laurent BC, Kornberg RD (1994) A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated from yeast. Proc Natl Acad Sci USA 91: 1950 – 1954
  PubMed CAS Google Scholar
• Castelli-Gair JE, García-Bellido A (1990) Interactions of Polycomb and trithorax with cis regulatory regions of Ultrabithorax during the development of Drosophila melanogaster. EMBO J 9: 4267 – 275
  PubMed CAS Google Scholar
• Cedar H (1988) DNA methylation and gene activity. Cell 53: 3 – 4
  PubMed CAS Google Scholar
• Chan C-S, Rastelli L, Pirrotta V (1994) A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression. EMBO J 13: 2553 – 2564
  PubMed CAS Google Scholar
• Chaplin TC, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD (1995a) A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. Blood 85: 1435 – 1441
  CAS Google Scholar
• Chaplin TC, Bernard OA, Beverloo HB, Saha V, Hagemeijer A, Berger R, Young BD (1995b) The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene. Blood 86: 2073 – 2076
  CAS Google Scholar
• Chen CS, Medberry PS, Arthur DC, Kersey JH (1991) Breakpoint clustering in t(4;11) (q21;q23) acute leukemia. Blood 78: 2498 – 2504
  PubMed CAS Google Scholar
• Chen CS, Hilden JM, Frestedt J, Domer PH, Moore R, Korsmeyer SJ, Kersey JH (1993a) The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia. Blood 82: 1080 – 1085
  CAS Google Scholar
• Chen CS, Sorensen PH, Domer PH, Reaman GH, Korsmeyer SJ, Heerema NA, Hammond GD, Kersey JH (1993b) Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome. Blood 81: 2386 – 2393
  CAS Google Scholar
• Churchill M, Susuki M (1989) “SPKK” motifs prefer to bind DNA at AT-rich sites. EMBO J 8: 4189–4195
  Google Scholar
• Cimino G, Moir DT, Canaani O, Williams K, Crist WM, Katzav S, Cannizzaro L, Lange B, Nowell PC, Croce CM, Canaani E (1991) Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations. Cancer Res 51: 6712 – 6714
  PubMed CAS Google Scholar
• Cimino G, Nakamura T, Gu Y, Canaani O, Prasad P, Crist WM, Carroll AJ, Baer M, Bloomfield CD, Nowell PC, Croce CM, Canaani E (1992) An altered 11-kilobase transcript in leukemic cell lines with the t(4;11)(q21;q23) chromosome translocation. Cancer Res 52: 3811 – 3813
  PubMed CAS Google Scholar
• Cimino G, Lo Coco F, Biondi A, Elia L, Luciano A, Croce CM, Masera G, Mandelli F, Canaani E (1993) ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy. Blood 82: 544 – 546
  PubMed CAS Google Scholar
• Cimino G, Rapanotti MC, Elia L, Biondi A, Fizzotti M, Testi AM, Tosti S, Croce CM, Canaani E, Mandelli F, Lo Coco F (1995a) ALL-1 gene rearrangements in acute myeloid leukemia: association with M4-M5 French-American-British classification subtypes and young age. Cancer Res 55: 1625 – 1628
  CAS Google Scholar
• Ciminio G, Rapanotti MC, Rivolta A, Lo Coco F, D’Arcangelo E, Rondelli R, Basso G, Barisone E, Rosanda C, Santostasi T, Canaani E, Masera G, Mandelli F, Biondi A (1995b) Prognostic relevance of ALL-1 gene rearrangement in infant acute leukemias. Leukemia 9: 391 – 395
  Google Scholar
• Corral J, Forster A, Thompson S, Lampert F, Kaneko Y, Slater R, Kroes WG, van der Schoot CE, Ludwig WD, Karpas A, Pocock C, Cotter F, Rabbitts TH (1993) Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation. Proc Natl Acad Sci USA 90: 8538 – 8542
  PubMed CAS Google Scholar
• Côté J, Quinn J, Workman JL, Peterson CL (1994) Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex. Science 265: 53 – 60
  PubMed Google Scholar
• Croston GE, Kerrigan LA, Lira LM, Marshak DR, Kadonaga JT (1991) Sequence-specific antirepression of histone H1-mediated inhibition of basal RNA polymerase II transcription. Science 251: 643 – 649
  PubMed CAS Google Scholar
• Djabali M, Selleri L, Parry P, Bower M, Young BD, Evans GA (1992) A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nat Gen 2: 113 – 118
  CAS Google Scholar
• Domer PH, Fakharzadeh SS, Chen CS, Jockel J, Johansen L, Silverman GA, Kersey JH, Korsmeyer SJ (1993) Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. Proc Natl Acad Sci USA 90: 7884 – 7888
  PubMed CAS Google Scholar
• Domer PH, Head DR, Renganathan N, Raimondi SC, Yang E, Atlas M (1995) Molecular analysis of 13 cases of MLL/11q23 secondly acute leukemia and identification of topoisomerase II consensus-binding sequences near chromosome breakpoint of a secondary leukemia with the t(4;11). Leukemia 9: 1305 – 1312
  PubMed CAS Google Scholar
• Downing JR, Head DR, Raimondi SC, Carroll AJ, Curcio-Brint AM, Motroni TA, Hulshof MG, Pullen DJ, Domer PH (1994) The der(11)-encoded MLL/AF-4 fusion transcript is consistently detected in t(4;11)(q21;q23)-containing acute lymphoblastic leukemia. Blood 83: 330 – 335
  PubMed CAS Google Scholar
• Farkas G, Gausz J, Galloni M, Reuter G, Gyurkovics H, Karch F (1994) The Trithorax-like gene encodes the Drosophila GAGA factor. Nature 371: 806 – 808
  PubMed CAS Google Scholar
• Fazioli F, Minichiello L, Matoskova B, Wong WT, Di Fiore P (1993) eps15, a novel tyrosine kinase substrate, exhibits transforming activity. Mol Cell Biol 13: 5814–5828
  Google Scholar
• Felix CA, Winick NJ, Negrini M, Bowman WP, Croce CM, Lange BJ (1993) Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia. Cancer Res 53: 2954 – 2956
  PubMed CAS Google Scholar
• Felix CA, Hosler MR, Winick NJ, Masterson M, Wilson AE, Lange BJ (1995) ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children. Blood 85: 3250 – 3256
  PubMed CAS Google Scholar
• Ford AM, Ridge SA, Cabrera ME, Mahmoud H, Steel CM, Chan LC, Greaves M (1993) In utero rearrangements in the trithorax-related oncogene in infant leukaemias. Nature 363: 358 – 360
  PubMed CAS Google Scholar
• Galili N, Davis RJ, Fredericks WJ, Mukhopadhyay S, Rauscher FJ III, Emanuel BS, Rovera G, Barr FG (1993) Fusion of fork head domain gene to PAX3 in solid tumor alveolar rhabdomyosarcoma. Nat Gen 5: 230 – 235
  CAS Google Scholar
• Gasser SM, Amati BB, Cardenas ME, Hoffman JF-X (1989) Studies on scaffold-attachment sites and their relation to genome function. In: Jeon KW, Friedlander M (eds) Int Rev Cytol Acad Press, New York
  Google Scholar
• Gill Super HJ, McCabe NR, Thirman MJ, Larson RA, Le Beau MM, Pedersen-Bjergaard J, Philip P, Diaz MO, Rowley JD (1993) Rearrangements of the MLL gene in theraphy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II. Blood 82: 3705 – 3711
  Google Scholar
• Gill Super HJ, Rothberg PG, Kobayashi H, Freeman AI, Diaz MO, Rowley JD (1994) Clonal, non-constitutional rearrangements of the MLL gene in infant twins with acute lymphoblastic leukemia: in utero chromosome rearrangement of 11q23. Blood 83: 641 – 644
  PubMed CAS Google Scholar
• Gindhart JG Jr, Kaufman TC (1995) Identification of Polycomb and trithorax group responsive elements in the regulatory region of the Drosophila homeotic gene Sex combs reduced. Genetics 139: 797 – 814
  PubMed CAS Google Scholar
• Gu Y, Cimino G, Alder H, Nakamura T, Prasad R, Canaani O, Moir DT, Jones C, Nowell PC, Croce CM, Canaani E (1992a) The (4;11)(q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase. Proc Natl Acad Sci USA 89: 10464 – 10468
  CAS Google Scholar
• Gu Y, Nakamura T, Alder H, Prasad R, Canaani O, Cimino G, Croce CM, Canaani E (1992b) The t(4; 11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71: 701 – 708
  CAS Google Scholar
• Gu Y, Alder H, Nakamura T, Schichman SA, Prasad R, Canaani O, Saito H, Croce CM, Canaani E (1994) Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia. Cancer Res 54: 2326–2330
  Google Scholar
• Height SE, Dainton MG, Kearney L, Swansbury GJ, Matutes E, Dyer MJ, Treleaven JG, Powles RL, Catovsky D (1994) Acute myelomonocytic leukemia with t(10;11)(p13;q23): heterogeneity of breakpoints at 11q23 and association with recombinase activation. Genes Chromosome Cancer 11: 136 – 139
  CAS Google Scholar
• Henry NL, Campbell AM, Feaver WJ, Poon D, Weil PA, Kornberg RD (1994) TFIIF-TAF-RNA polymerase II connection. Genes Dev 8: 2868 – 2878
  PubMed CAS Google Scholar
• Hernandez JM, Mecucci C, Beverloo HB, Selleri L, Wlodarska I, Stul M, Michaux L, Verhoef G, Van Orshoven A, Cassiman JJ, Evans GA, Hagemeijer A, Van den Berghe H (1995) Translocation (11;15)(q23;q14) in three patients with acute non-lymphoblastic leukemia (ANLL); clinical, cytogenetic and molecular studies. Leukemia 9: 1162 – 1166
  PubMed CAS Google Scholar
• Hilden JM, Chen CS, Moore R, Frestedt J, Kersey JH (1993) Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the polymerase chain reaction in t(4;11) acute leukemia. Cancer Res 53: 3853 – 3856
  PubMed CAS Google Scholar
• Hunger SP, Tkachuk DC, Amylon MD, Link MP, Carroll AJ, Welborn JL, Willman CL, Cleary ML (1993) HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities. Blood 81: 3197 – 3203
  PubMed CAS Google Scholar
• Iida S, Seto M, Yamamoto K, Komatsu H, Akao Y, Nakazawa S, Ariyoshi Y, Takahashi T, Ueda R (1993a) Molecular cloning of 19p13 breakpoint region in infantile leukemia with t(11;19)(q23;p13) translocation. Jpn J Cancer Res 84: 532 – 537
  CAS Google Scholar
• Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R (1993b) MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13. Oncogene 8: 3085 – 3092
  CAS Google Scholar
• Imbalzano AN, Kwon H, Green MR, Kingston RE (1994) Facilitated binding of TATA-binding protein to nucleosomal DNA. Nature 370: 481 – 185
  PubMed CAS Google Scholar
• Jani Sait SN, Raimondi SC, Look AT, Gill H, Thirman M, Diaz MO, Shows TB (1993) A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL gene. Genes Chromosom Cancer 7: 28 – 31
  PubMed CAS Google Scholar
• Janssen JWG, Ludwig WD, Borkhardt A, Spadinger U, Rieder H, Fontasch C, Hossfeld DK, Harbott J, Schulz AS, Repp R, Sykora KW, Hoelzer D, Bartram CR (1994) Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease during complete remission. Blood 84: 3835 – 3842
  PubMed CAS Google Scholar
• Jones RS, Gelbart WM (1993) The Drosophila polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax. Mol Cell Bio1 13: 6357 – 6366
  CAS Google Scholar
• Kearney L, Bower M, Gibbons B, Das S, Chaplin T, Nacheva E, Chessells JM, Reeves B, Riley JH, Lister TA, Young BD (1992) Chromosome 11q23 translocations in both infant and adult acute leukemias are detected by in situ hybridization with a yeast artificial chromosome. Blood 80: 1659 – 1665
  Google Scholar
• Kennison JA (1993) Transcriptional activation of Drosophila homeotic genes from distant regulatory elements. Trends Genet 9: 75 – 79
  PubMed CAS Google Scholar
• Khavari PA, Peterson CL, Tamkun JW, Mendel DB, Crabtree GR (1993) BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. Nature 366: 170 – 174
  PubMed CAS Google Scholar
• Kobayashi H, Espinosa R, Thirman MJ, Gill HJ, Fernald AA, Diaz MO, Le Beau MM, Rowley JD (1993) Heterogeneity of breakpoints of 11q23 rearrangements in hematologic malignancies identified with fluorescence in situ hybridization. Blood 82: 547 – 551
  PubMed CAS Google Scholar
• Krumlauf R (1994) Hox genes in vertebrate development. Cell 78: 191 – 201
  PubMed CAS Google Scholar
• Kuzin B, Tillib S, Sedkov Y, Mizrokhi L, Mazo A (1994) The Drosophila trithorax gene encodes a chromosomal protein and directly regulates the region-specific homeotic gene fork head. Genes Dev 8: 2478 – 2490
  PubMed CAS Google Scholar
• Kwon H, Imbalzano AN, Khavari PA, Kingston RE, Green MR (1994) Nucleosome disruption and enhancement of activator binding by a human SWI/SNF complex. Nature 370: 477 – 481
  PubMed CAS Google Scholar
• Lanza C, Gaidano G, Cimino G, Lo Coco F, Basso G, Sainati L, Pastore C, Nomdedeu J, Volpe G, Parvis G, Barisone E, Mazza U, Madon E, Saglio G (1995) p53 gene inactivation in acute lymphoblastic leukemia of B cell lineage associates with chromosomal breakpoints at 11q23 and 8q24. Leukemia 9: 955–959
  Google Scholar
• Leblanc T, Hillion J, Derre J, Le Coniai M, Baruchel A, Daniel MT, Berger R (1994) Translocation t(11;11)(q13;q23) and HRX gene rearrangement associated with therapy-related leukemia in a child previously treated with VP16. Leukemia 8: 1646 – 1648
  PubMed CAS Google Scholar
• Leonhardt H, Page AW, Weier H-U, Bestor TH (1992) A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell 71: 865 – 873
  PubMed CAS Google Scholar
• Li E, Bestor TH, Jaenisch R (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69: 915 – 926
  PubMed CAS Google Scholar
• Lonie A, D’Andrea R, Paro R, Saint R (1994) Molecular characterization of the Polycomblike gene of _Drosophila melanogaster, a trans_-acting negative regulator of homeotic gene expression. Development 120: 2629–2636
  Google Scholar
• Ma Q, Alder H, Nelson KK, Chatterjee D, Gu Y, Nakamura T, Canaani E, Croce CM, Siracusa LD, Buchberg AM (1993) Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases. Proc Natl Acad Sci USA 90: 6350 – 6354
  PubMed CAS Google Scholar
• Marschalek R, Greil J, Lochner K, Nilson I, Siegler G, Zweckbronner I, Beck JD, Fey GH (1995) Molecular analysis of the chromosomal breakpoint and fusion transcripts in the acute lymphoblastic SEM cell line with chromosomal translocation t(4;11). Br J Haematol 90: 308 – 320
  PubMed CAS Google Scholar
• Martinex-Climent JA, Thirman MJ, Espinosa R III, Le Beau MM, Rowley JD (1995) Detection of 11q23/MLL rearrangements in infant leukemias with fluorescence in situ hybridization and molecular analysis. Leukemia 9: 1299 – 1304
  Google Scholar
• Mazo AM, Huang DH, Mozer BA, Dawid IB (1990) The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains. Proc Natl Acad Sci USA 87: 2112 – 2116
  PubMed CAS Google Scholar
• McCabe NR, Burnett RC, Gill HJ, Thirman MJ, Mbangkollo D, Kipiniak M, van Melle E, Ziemin-van der Poel S, Rowley JD, Diaz MO (1992) Cloning of cDNAs of the MLL gene that detect DNA rearrangements and altered RNA transcripts in human leukemic cells with 11q23 translocations. Proc Natl Acad Sci USA 89: 11794 – 11798
  CAS Google Scholar
• McCabe NR, Kipiniak M, Kobayashi H, Thirman M, Gill H, Rowley JD, Diaz MO (1994) DNA rearrangements and altered transcripts of the MLL gene in a human T-ALL cell line Karpas 45 with a t(X;11)(q13;q23) translocation. Genes Chromosom Cancer 9: 221 – 224
  PubMed CAS Google Scholar
• McGinnis W, Krumlauf R (1992) Homeobox genes and axial patterning. Cell 68: 283 – 302
  PubMed CAS Google Scholar
• Milner CM, Campbell RD (1993) The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats. Biochem J 290: 811 – 818
  PubMed CAS Google Scholar
• Mitani K, Kanda Y, Ogawa S, Tanaka T, Inazawa J, Yazaki Y, Hirai H (1995) Cloning of several species of MLL/MEN chimeric cDNAs in myeloid leukemia with t(11;19)(q23;p13.1) translocation. Blood 85: 2017 – 2024
  PubMed CAS Google Scholar
• Morgan GJ, Cotter F, Katz FE, Ridge SA, Domer P, Korsmeyer S, Wiedemann LM (1992) Breakpoints at 11q23 in infant leukemias with the t(11;19) (q23;p13) are clustered. Blood 80: 2172 – 2175
  PubMed CAS Google Scholar
• Morrissey J, Tkachuk DC, Milatovich A, Francke U, Link M, Cleary ML (1993) A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias. Blood 81: 1124 – 1131
  PubMed CAS Google Scholar
• Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, Croce CM, Canaani E (1993) Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Proc Natl Acad Sci USA 90: 4631 – 4635
  PubMed CAS Google Scholar
• Naoe T, Kubo K, Kiyoi H, Ohno R (1993) Involvement of the MLL/ALL-1 gene associated with multiple point mutations of the N-ras gene in acute myeloid leukemia with t(11;17)(q23;q25). Blood 82: 2260 – 2261
  PubMed CAS Google Scholar
• Negrini M, Felix CA, Martin C, Lange BJ, Nakamura T, Canaani E, Croce CM (1993) Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia. Cancer Res 53: 4489 – 4492
  PubMed CAS Google Scholar
• Paro R (1990) Imprinting a determined state into the chromatin of Drosophila. Trends Genet 6: 416–421
  Google Scholar
• Paro R (1993) Mechanisms of heritable gene repression during development of Drosophila. Curr Opin Cell Biol 5: 999 – 1005
  Google Scholar
• Parry P, Djabali M, Bower M, Khristich J, Waterman M, Gibbons B, Young BD, Evans G (1993) Structure and expression of the human trithorax-like gene 1 involved in acute leukemias. Proc Natl Acad Sci USA 90: 4738 – 4742
  PubMed CAS Google Scholar
• Parry P, Wei Y, Evans G (1994) Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family. Genes, Chromosom Cancer 11: 79–84 Pedersen-Bjergaard J, Rowley JD (1994) The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation. Blood 83: 2780 – 2786
  Google Scholar
• Pocock CFE, Malone M, Booth M, Evans M, Morgan G, Greil J, Cotter FE (1995) BCL-2 expression by leukaemic blasts in a SCID mouse model of biphenotypic leukaemia associated with the t(4;11)(q21;q23) translocation. Brit J Haematol 90: 855 – 867
  CAS Google Scholar
• Prasad R, Gu Y, Alder H, Nakamura T, Canaani O, Saito H, Huebner K, Gale RP, Nowell PC, Kuriyama K, Miyazaki Y, Croce CM, Canaani E (1993) Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6; 11) chromosome translocation. Cancer Res 53: 5624 – 5628
  PubMed CAS Google Scholar
• Prasad R, Leshkowitz D, Gu Y, Alder H, Nakamura T, Saito H, Huebner K, Berger R, Croce CM, Canaani E (1994) Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia. Proc Natl Acad Sci USA 91: 8107 – 8111
  PubMed CAS Google Scholar
• Pui CH, Behm FG, Downing JR, Hancock ML, Shurtleff SA, Ribeiro RC, Head DR, Mahmoud HH, Sandlund JT, Furman WL, Roberts WM, Crist WM, Raimondi SC (1994) 11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia. J Clin Oncol 12: 909–915
  Google Scholar
• Rastelli L, Chan CS, Pirrotta V (1993) Related chromosome binding sites for zeste, suppressor of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function. EMBO J 12: 1513 – 1522
  PubMed CAS Google Scholar
• Reeves R (1992) Chromatin changes during the cell cycle. Current Biol 4: 413 – 423
  CAS Google Scholar
• Reeves R, Nissen MS (1990) The AT-DNA-binding domain of mammalian high mobility group chromosomal proteins: a novel peptide motif for recognizing DNA structure. J Biol Chem 265: 8573 – 8582
  PubMed CAS Google Scholar
• Rowley JD (1992) The der(11) chromosome contains the critical breakpoint junction in the 4; 11, 9; 11, and 11;19 translocations in acute leukemia. Genes Chromosom Cancer 5: 264 – 266
  CAS Google Scholar
• Rowley JD, Diaz MO, Espinosa R, Patel YD, van Melle E, Ziemin S, Taillon-Miller P, Lichter P, Evans GA, Kersey JH, Ward DC, Domer PH, LeBeau MM (1990) Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: identification of 11q23 translocation breakpoints with a yeast artificial chromosome. Proc Natl Acad Sci USA 87: 9358 – 9362
  PubMed CAS Google Scholar
• Rubnitz JE, Link MP, Shuster JJ, Carroll AJ, Hakami N, Frankel LS, Pullen DJ, Cleary ML (1994a) Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: a Pediatric Oncology Group study. Blood 84: 570 – 573
  CAS Google Scholar
• Rubnitz JE, Morrissey J, Savage PA, Cleary ML (1994b) ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells. Blood 84: 1747 – 1752
  CAS Google Scholar
• Sachs AB, Deardorff JA (1992) Translation initiation requires the PAB-dependent poly (A) ribonuclease in yeast. Cell 70: 961 – 973
  PubMed CAS Google Scholar
• Schichman SA, Caligiuri MA, Gu Y, Strout MP, Canaani E, Bloomfield CD, Croce CM (1994a) All-1 partial duplication in acute leukemia. Proc Natl Acad Sci USA 91: 6236 – 6239
  CAS Google Scholar
• Schichman SA, Caligiuri MA, Strout MP, Carter SL, Gu Y, Canaani E, Bloomfield CD, Croce CM (1994b) All-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between Alu elements. Cancer Res 54: 4277 – 4280
  CAS Google Scholar
• Schichman SA, Canaani E, Croce CM (1995) Self-fusion of the ALL1 gene. A new genetic mechanism for acute leukemia. JAMA 273: 571 – 576
  PubMed CAS Google Scholar
• Sedkov Y, Tillib S, Mizrokhi L, Mazo A (1994) The bithorax complex is regulated by trithorax earlier during Drosophila embryogenesis than is the Antennapedia complex, correlating with a bithorax- like expression pattern of distinct early trithorax transcripts. Development 120: 1907 – 1917
  PubMed CAS Google Scholar
• Slovak ML, Traweek ST, Willman CL, Head DR, Kopecky KJ, Magenis RE, Appelbaum FR, Forman SJ (1995) Trisomy 11: an association with stem/progenitor cell immunophenotype. Brit J Haematol 90: 266 – 273
  CAS Google Scholar
• Sorensen PH, Chen CS, Smith FO, Arthur DC, Domer PH, Bernstein ID, Korsmeyer SJ, Hammond GD, Kersey JH (1994) Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotype. J Clin Invest 93: 429 – 437
  PubMed CAS Google Scholar
• Stock W, Thirman MJ, Dodge RK, Rowley JD, Diaz MO, Wurster-Hill D, Sobol RE, Davey FR, Larson RA, Westbrook CA, Bloomfield CD (1994) Detection of MLL gene rearrangements in adult acute lymphoblastic leukemia. A Cancer and Leukemia Group B study. Leukemia 8: 1918 – 1922
  PubMed CAS Google Scholar
• Surowy C, Hoganson G, Gosink J, Strunk K, Spritz R (1990) The human RD protein is closely related to nuclear RNA-binding proteins that has been conserved. Gene 90: 299 – 302
  PubMed CAS Google Scholar
• Susuki M (1989) SPKK, a new nucleic acid-binding unit of protein found in histone. EMBO J 8: 797–804
  Google Scholar
• Tamkun JW, Deuring R, Scott MP, Kissinger M, Pattatucci AM, Kaufman TC, Kennison JA (1992) brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2. Cell 68: 561 – 572
  Google Scholar
• Theissen J, Etzerodt M, Reuter R, Schneider C, Lottspeich F, Argos P, Lührmann R, Philipson L (1986) Cloning of the human cDNA for the Ul RNA-associated 70K protein. EMBO J 5: 3209 – 3217
  PubMed CAS Google Scholar
• Thirman MJ, Gill HJ, Burnett RC, Mbangkollo D, McCabe NR, Kobayashi H, Ziemin-van der Poel S, Kaneko Y, Morgan R, Sandberg AA, Chaganti RSK, Larson RA, Le Beau MM, Diaz MO, Rowley JD (1993a). Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. New Engl J Med 329: 909 – 914
  CAS Google Scholar
• Thirman MJ, Mbangkollo D, Kobayashi H, McCabe NR, Gill HJ, Rowley JD, Diaz MO (1993b) Molecular analysis of 3’ deletions of the MLL gene in 11q23 translocation reveals that the zinc finger domain of MLL are often deleted. Proc American Assoc Cancer Res 34: 495 (abstr)
  Google Scholar
• Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD (1994) Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia. Proc Natl Acad Sci USA 91: 12110 – 12114.
  PubMed CAS Google Scholar
• Thompson KA, Wang B, Argraves WS, Giancotti FG, Scxhrank DP, Ruoslahti E (1994) BR140, a novel zinc-finger protein with homology to the TAF250 subunit of TFIID. Biochem Biophys Res Commun 198: 1143 – 1152
  PubMed CAS Google Scholar
• Tkachuk DC, Kohler S, Cleary ML (1992) Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71: 691 – 700
  PubMed CAS Google Scholar
• Tschiersch B, Hofmann A, Krauss V, Dorn R, Korge G, Reuter G (1994) The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var) 3–9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J 13: 3822 – 3831
  PubMed CAS Google Scholar
• Tsukiyama T, Becker PB, Wu C (1994) ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor. Nature 367: 525 – 532
  PubMed CAS Google Scholar
• Tse W, Zhu W, Chen HS, Cohen A (1995) A novel gene, AF1q, fused to MLL in t(1;11)(q21;q23), is specifically expressed in leukemic and immature hematopoietic cells. Blood 85: 650 – 656
  PubMed CAS Google Scholar
• Welch MD, Drubin DG (1994) A nuclear protein with sequence similarity to proteins implicated in human leukemias is important for cellular morphogenesis and actin cytoskeletal function in Saccharomyces cerevisiae. Mol Biol Cell 5: 617 – 632
  PubMed CAS Google Scholar
• Winston F, Carlson M (1992) Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection. Trends Genet 8: 387 – 392
  PubMed CAS Google Scholar
• Wolfe AP (1991) Developmental regulation of chromatin structure and function. Trends Cell Biol 1: 61 – 66
  Google Scholar
• Wolfe AP (1994) Transcription: in tune with histones. Cell 77: 13 – 16
  Google Scholar
• van der Lugt NMT, Domen J, Linders K, van Roon M, Robanus-Maandag E, te Riele H, van der Valk M, Deschamps J, Sofroniew M, van Lohuizen M, Berns A (1994) Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with targeted deletion of the bmi-1 proto-oncogene. Genes Dev 8: 757 – 769
  PubMed Google Scholar
• van Lohuizen M, Frasch M, Wientjes E, Berns A (1991) Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2. Nature 353: 353 – 355
  PubMed Google Scholar
• Yamamoto K, Seto M, Akao Y, Iida S, Nakazawa S, Oshimura M, Takahashi T, Ueda R (1993a) Gene rearrangement and truncated mRNA in cell lines with 11q23 translocation. Oncogene 8: 479 – 485
  CAS Google Scholar
• Yamamoto K, Seto M, Komatsu H, Iida S, Akao Y, Kojima S, Kodera Y, Nakazawa S, Ariyoshi Y, Takahashi T, Ueda R (1993b) Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia. Oncogene 8: 2617 – 2625
  CAS Google Scholar
• Yu BD, Hess JL, Horning SE, Brown G, Korsmeyer SJ (1995) The mixed-lineage leukemia gene is required for Hox gene expression and proper segment identity. Blood 86: 123a
  Google Scholar
• Zeleznik-Le NJ, Harden AM, Rowley JD (1994) 11q23 translocations split the “AT-hook” cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene. Proc Natl Acad Sci USA 91: 10610–10614
  Google Scholar
• Ziemen-van der Poel S, McCabe NR, Gill HJ, Espinosa R III, Patel Y, Harden A, Rubinelli P, Smith SD, LeBeau MM, Rowley JD, Diaz MO (1991) Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci USA 88: 10735 – 10739
  Google Scholar
• Zink B, Engstrom Y, Gehring WJ, Paro R (1991) Direct interaction of the Polycomb protein with Antennapedia regulatory sequences in polytene chromosomes of Drosophila melanogaster. EMBO J 10: 153 – 162
  PubMed CAS Google Scholar

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