A New Form of Epstein-Barr Virus Latency in vivo (original) (raw)

Abstract

Epstein-Barr virus is a human herpesvirus that is associated with a number of tumors including Burkitts lymphoma, immunoblastic lymphoma, Hodgkins lymphoma, rare T cell lymphomas and nasopharyngeal carcinoma, suggesting a relatively broad tissue tropism for the virus in vivo [1,2]. Immunosuppression through allograft transplantation or HIV infection is known to promote the development of EBV positive tumors, particularly immunoblastic lymphomas. In vitro the virus has a strong tropism for B cells which it infects and causes to become latently infected, immortalized lymphoblasts. This is the only model system for EBV latency in a normal cell. These latently infected cells express 9 known latent proteins and high levels of cell surface markers, such as CD23, that are characteristically expressed on activated B cells [3,4].

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Epstein–Barr virus latent genes

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Authors and Affiliations

  1. Dept. of Pathology, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA, 02111, USA
    E. Miyashita & D. A. Thorley-Lawson

Authors

  1. E. Miyashita
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  2. D. A. Thorley-Lawson
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Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute National Institutes of Health, Bldg. 37, Rm. 2B04, 20892, Bethesda, MD, USA
    Michael Potter M.D. (Chief) (Chief)
  2. Institute for Immunology, Grenzacherstr. 487, CH-4005, Basel, Switzerland
    Fritz Melchers (Director) (Director)

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© 1995 Springer-Verlag Berlin Heidelberg

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Miyashita, E., Thorley-Lawson, D.A. (1995). A New Form of Epstein-Barr Virus Latency in vivo. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1994. Current Topics in Microbiology and Immunology, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79275-5\_17

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