A New Form of Epstein-Barr Virus Latency in vivo (original) (raw)
Abstract
Epstein-Barr virus is a human herpesvirus that is associated with a number of tumors including Burkitts lymphoma, immunoblastic lymphoma, Hodgkins lymphoma, rare T cell lymphomas and nasopharyngeal carcinoma, suggesting a relatively broad tissue tropism for the virus in vivo [1,2]. Immunosuppression through allograft transplantation or HIV infection is known to promote the development of EBV positive tumors, particularly immunoblastic lymphomas. In vitro the virus has a strong tropism for B cells which it infects and causes to become latently infected, immortalized lymphoblasts. This is the only model system for EBV latency in a normal cell. These latently infected cells express 9 known latent proteins and high levels of cell surface markers, such as CD23, that are characteristically expressed on activated B cells [3,4].
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Epstein–Barr virus latent genes
Article Open access 23 January 2015
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- Dept. of Pathology, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA, 02111, USA
E. Miyashita & D. A. Thorley-Lawson
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- E. Miyashita
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- Laboratory of Genetics, National Cancer Institute National Institutes of Health, Bldg. 37, Rm. 2B04, 20892, Bethesda, MD, USA
Michael Potter M.D. (Chief) (Chief) - Institute for Immunology, Grenzacherstr. 487, CH-4005, Basel, Switzerland
Fritz Melchers (Director) (Director)
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Miyashita, E., Thorley-Lawson, D.A. (1995). A New Form of Epstein-Barr Virus Latency in vivo. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1994. Current Topics in Microbiology and Immunology, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79275-5\_17
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