Relationship of Neuron Specific Enolase and Protein S-100 Concentrations in Systemic and Jugular Venous Serum to Injury Severity and Outcome after Traumatic Brain Injury (original) (raw)

Summary

Neuron specific enolase (NSE) and protein S-100 have previously been described as markers of brain injury. We aimed to discover whether concentrations of either were raised in arterial and jugular venous serum after traumatic brain injury, and whether serum profiles were related to injury severity and neurological outcome. We recruited 22 patients with a traumatic brain injury who were admitted to the intensive care unit. Paired arterial and jugular venous blood samples were taken on admission, and at 24, 48 and 96 hrs after injury. Samples were analysed for NSE and S-100 by RIA. Concentrations of both NSE and S-100 were increased above controls — mean NSE concentration was highest on admission, whilst mean S-100 peaked at 24 hours after injury. There was a small, but significant difference between jugular venous and arterial concentrations of S-100 (p = 0.022). High NSE and S-100 concentrations were significantly related to poor neurological outcome (p = 0.004 and p < 0.001 respectively). Both serum NSE and S-100 may be of some value in helping to predict outcome after a traumatic brain injury.

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Authors and Affiliations

  1. Department of Anaesthetics, University of Edinburgh, Western General Hospital, Edinburgh, UK
    E. Grant McKeating FRCA, P. J. D. Andrews & L. Mascia

Authors

  1. E. Grant McKeating FRCA
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  2. P. J. D. Andrews
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  3. L. Mascia
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Editors and Affiliations

  1. Medical College of Virginia, Richmond, Virginia, USA
    Anthony Marmarou Ph.D. & Ross Bullock M.D., Ph.D. &
  2. University Hospital Rotterdam, Rotterdam, The Netherlands
    Cees Avezaat M.D.
  3. University of Munich, Munich, Germany
    Alexander Baethmann M.D., Ph.D.
  4. UCLA School of Medicine, Los Angeles, California, USA
    Donald Becker M.D.
  5. University of Berlin, Berlin, Germany
    Mario Brock M.D.
  6. University of Michigan, Ann Arbor, Michigan, USA
    Julian Hoff M.D., Ph.D.
  7. Nagoya City University, Nagoya, Japan
    Hajime Nagai M.D.
  8. Ludwig Maximilians University, Munich, Germany
    Hans-J. Reulen M.D.
  9. Institute of Neurological Sciences, Glasgow, UK
    Graham Teasdale M.D.

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© 1998 Springer-Verlag Wien

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McKeating, E.G., Andrews, P.J.D., Mascia, L. (1998). Relationship of Neuron Specific Enolase and Protein S-100 Concentrations in Systemic and Jugular Venous Serum to Injury Severity and Outcome after Traumatic Brain Injury. In: Marmarou, A., et al. Intracranial Pressure and Neuromonitoring in Brain Injury. Acta Neurochirurgica Supplements, vol 71. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6475-4\_35

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