Principles of Neuronal Regeneration (original) (raw)

Summary

Studies of retrograde changes in axotomized motoneurons have revealed fundamental changes in morphology, metabolism and physiology of these cells. Restructuring of the granular endoplasmic reticulum, s.c. chromatolysis, seems to be the basis for increased and modified protein synthesis. While cytoskeletal proteins with the exception of the neurofilament triplet go up, enzymes and receptors related to neurotransmission go down and new growth associated proteins appear. There is an enhanced glucose uptake and iron metabolism. Complex changes in axonal transport have been observed. This may reflect the efforts of the regenerating nerve cell to compensate for its lost axon.

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Authors and Affiliations

  1. Department of Neuromorphology, Max-Planck-Institute of Psychiatry, D-82152, Martinsried, Federal Republic of Germany
    Georg W. Kreutzberg M.D.

Authors

  1. Georg W. Kreutzberg M.D.
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Editors and Affiliations

  1. Institut für Chirurgische Forschung, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München, Federal Republic of Germany
    Alexander Baethmann & Nikolaus Plesnila &
  2. Institut für Neurochirurgische Pathophysiologie, Johannes-Gutenberg-Universität, Mainz, Federal Republic of Germany
    Oliver S. Kempski
  3. Klinik für Neurochirurgie, Universität zu Köln, Köln, Federal Republic of Germany
    Frank Staub

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© 1996 Springer-Verlag

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Kreutzberg, G.W. (1996). Principles of Neuronal Regeneration. In: Baethmann, A., Kempski, O.S., Plesnila, N., Staub, F. (eds) Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma. Acta Neurochirurgica, vol 66. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9465-2\_18

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