Effects of Taurine Supplementation on Vascular Endothelial Function at Rest and After Resistance Exercise (original) (raw)

Abstract

High-intensity resistance exercise has been shown to increase arterial stiffness and reduce vascular endothelial function. Taurine supplementation has a favorable effect on maintaining vascular function. We had previously reported that taurine supplementation attenuated increases in resistance exercise–induced arterial stiffness. In the present study, we further investigate the effects of taurine supplementation on vascular endothelial function at rest and after resistance exercise.

Twenty-nine healthy men were recruited and randomly assigned to either the placebo supplement group (n = 14) or the taurine supplement group (n = 15) in a double-blinded manner. Subjects were required to ingest 6 g of either a placebo or the taurine supplement for 2 weeks prior to and 3 days following the exercise. Two weeks after the commencement of supplementation, the subjects were asked to perform 2 sets of 20 repetitive unilateral maximal-effort resistance exercise of the elbow flexors on a Biodex isokinetic dynamometer, with each contraction lasting 3 s, with 1 repetition performed every 9 s and 4 min rest in between sets. We evaluated the changes in brachial artery flow-mediated dilation (FMD) in the non-exercised arm as an index of vascular endothelial function. Relative and absolute FMDs were measured prior to supplementation, before exercise, and 24, 48, and 96 h after exercise.

Two weeks of taurine supplementation significantly increased both relative and absolute FMDs. Baseline diameter significantly increased at 96 h following the exercise in both groups. However, there was no change in the peak diameter. Consequently, both relative and absolute FMDs were significantly reduced at 96 h after the exercise in both groups. Taurine supplementation does not affect resistance exercise–induced reduction in FMD.

Two weeks of taurine supplementation (6 g/day) significantly increased vascular endothelial function at rest; however, taurine supplementation did not improve resistance exercise–induced reduction in FMD.

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Acknowledgements

We thank Dr. Yoshio Nakata and Dr. Nobutake Shimojo for providing scientific and technical support. The present work was supported by a Grant-in-Aid for the Japan Society for the Promotion of Science (JSPS) Fellows KAKENHI Grant Number 25711.

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Authors and Affiliations

1. Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan
   Song-Gyu Ra & Kentaro Kawanaka
2. Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan
   Youngju Choi, Hajime Ohmori & Seiji Maeda
3. Japan Institute of Sports Science, Tokyo, Japan
   Nobuhiko Akazawa

Authors

1. Song-Gyu Ra
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2. Youngju Choi
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3. Nobuhiko Akazawa
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4. Kentaro Kawanaka
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5. Hajime Ohmori
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6. Seiji Maeda
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Correspondence toSeiji Maeda .

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Editors and Affiliations

1. College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China
   Jianmin Hu
2. Department of Occupational and Environmental Health, Dalian Medicine University, Dalian, Liaoning, China
   Fengyuan Piao
3. Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, USA
   Stephen W. Schaffer
4. Department of Biology, Center for Developmental Neuroscience, College of Staten Island, Staten Island, NY, USA
   Abdeslem El Idrissi
5. Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA
   Jang-Yen Wu

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Ra, SG., Choi, Y., Akazawa, N., Kawanaka, K., Ohmori, H., Maeda, S. (2019). Effects of Taurine Supplementation on Vascular Endothelial Function at Rest and After Resistance Exercise. In: Hu, J., Piao, F., Schaffer, S., El Idrissi, A., Wu, JY. (eds) Taurine 11. Advances in Experimental Medicine and Biology, vol 1155. Springer, Singapore. https://doi.org/10.1007/978-981-13-8023-5\_38

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• DOI: https://doi.org/10.1007/978-981-13-8023-5\_38
• Published: 30 August 2019
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