Transport of molecules across tumor vasculature (original) (raw)
References
Jain RK, Weissbrod J, Wei J: Mass transfer in tumors: Characterization and applications in chemotherapy. Advances in Cancer Research 21: 37–47, 1980 Google Scholar
Gerlowski LE, Jain RK: Physiologically based pharmacokinetics: Principles and applications. J Pharm Sci, 72 (10): 1103–1127, 1983 Google Scholar
Jain RK: Mass and heat transfer in tumors. Advances in Transport Process 3: 205–339, 1984 Google Scholar
Jain RK: Transport of macromolecules in tumor microcirculation. Biotech Prog 1: 81–84, 1985 Google Scholar
Poste G: Drug targeting in cancer therapy. In: Gregoriadis G, Poste G, Senior J, Trouet A (eds) Receptor-mediated Targeting of Drugs. Plenum Publishing Corporation, New York, 1985, pp 427–474 Google Scholar
Schlom J: Basic principles and applications of monoclonal antibodies in the management of carcinomas. Cancer Res 46: 3225–3238, 1986 Google Scholar
Winkler C (editor): Nuclear Medicine in Clinical Oncology. New York: Springer-Verlag, 1986 Google Scholar
Jain RK: Transport of molecules in the tumor interstitium: A review. Cancer Res, 47: 3038–3050, 1987 Google Scholar
Jain RK, Ward-Hartley K: Tumor blood flow: Characterization, modifications, and role in hyperthermia. I.E.E.E. Trans Sonics and Ultrasonics, SU-31 (5): 504–526, 1984 Google Scholar
Poste G, Kirsh R, Bugelski P: Liposomes as a drug delivery system in cancer therapy. In: Sunkara P (ed) Novel Approaches to Cancer Chemotherapy. Academic Press, New York, 1984, pp 165–230 Google Scholar
Weiss L. Principles of Metastasis, New York, Academic Press, 1985 Google Scholar
Kawaguchi T, Nakamura K: Analysis of the lodgement and extravasation of tumor cells in experimental models of hematogenous metastasis. Cancer and Metastasis Reviews 5: 77–94, 1986 Google Scholar
Jain R, Ward-Hartley K: Dynamics of cancer cell interactions with microvasculature and interstitium. Biorheology 24: 117–125, 1987 Google Scholar
Starling EH: On the absorption of fluids from the connective tissue spaces. J Physiol (London) 19: 312–326, 1896 Google Scholar
Gullino PM: Extracellular compartments of solid tumors. In: Becker FF (ed) Cancer, Volume 3, Plenum Press, New York, 1975, pp 327–354 Google Scholar
Wiedeman MP, Tuma RF, Mayrovitz HN: An Introduction to Microcirculation, New York, Academic Press, 1981 Google Scholar
Wiedeman MP: Architecture. In: Renkin EM, Michel CC (eds) Handbook of Physiology — The Cardiovascular System, Section 2, Volume IV, Microcirculation, Chapter 2. American Physiological Society, Bethesda, MD, 1984, pp 11–40 Google Scholar
Simionescu M, Simionescu N: Ultrastructure of the microvascular wall: functional correlations. In: Renkin EM, Michel CC (eds) Handbook of Physiology — The Cardiovascular System, Section 2, Volume IV, Microcirculation, Chapter 3. American Physiological Society, Bethesda, MD, 1984, pp 41–101 Google Scholar
Persson CGA, Svensjö E: Vascular responses and their suppression: drugs interfering with venular permeability. Handbook of Inflammation, 5: 61–82, 1985 Google Scholar
Folkman J: Tumor angiogenesis. Adv Cancer Res 43: 175–203, 1985 Google Scholar
Warren BA: The vascular morphology of tumors. In: Peterson HI (ed) Tumor Blood Circulation, Chapter 1. CRC Press Inc., Boca Raton FL, 1979, pp 1–47 Google Scholar
Warren BA:In vivo and electron microscopic study of vessels in a hemangiopericytoma of the hamster. Angiologica, 5: 230, 1968 Google Scholar
Warren BA: The ultrastructure of the microcirculation of the advancing edge of Walker 256 carcinoma. Microvasc Res 2: 443–453, 1970 Google Scholar
Groscurth P, Kistler G: Human renal cell carcinoma in the nude mouse: long term observations. Beitr Pathol 160: 337, 1977 Google Scholar
Hirano A, Matsui T: Vascular structures in brain tumors. Human Pathol 6: 611–621, 1975 Google Scholar
Vogel AW: Intratumoral vascular changes with increased size of a mammary adenocarcinoma: New methods and results. J Natl Cancer Inst 34: 571–578, 1965 Google Scholar
Warren BA, Chauvin WJ: Transmission and scanning electron microscopy of renal adenocarcinoma. Ann Royal Con Phys Surg Can 10: 74, 1977 Google Scholar
Dvorak HF, Singer DR, Dvorak AM, Harvery VS, McDonagh J: Regulation of extravascular coagulation by microvascular permeability. Science 227: 1059–1061, 1985 Google Scholar
Warren BA, Shubik P: The growth of the blood supply to melanoma transplants in the hamster cheek pouch chamber. Lab Invest 15: 464, 1966 Google Scholar
Cliff WJ: Observations on healing tissue: a combined light and electron microscopic investigation. Philos Trans Roy Soc, London, Series B, 246: 305–325, 1963 Google Scholar
Warren BA, Shubik P, Feldman R: Metastasis via the blood stream: the method of intravasation of tumor cells in a transplantable melanoma of the hamster. Cancer Lett 4: 245–251, 1978 Google Scholar
Krogh A: The Anatomy and Physiology of Capillaries. New Haven, CT: Yale Univ Press, 1929, p 326 Google Scholar
Landis EM: Micro-injection studies of capillary permeability. II. The relation between capillary pressure and the rate at which fluid passes through the walls of single capillaries. Am J Physiol 82: 217–238, 1927 Google Scholar
Pappenheimer JR, Renkin EM, Borrero LM: Filtration, diffusion and molecular sieving through peripheral capillary membranes: A contribution to the pore theory of capillary permeability. Am J Physiol 167: 13–46, 1951 Google Scholar
Palade GE: Fine structure of blood capillaries. [Abstract], J Appl Physiol 24: 1424, 1953 Google Scholar
Karnovsky MJ: The ultrastructural basis of capillary permeability studies with peroxidase as a tracer. J Cell Biol 35: 213–236, 1967 Google Scholar
Simionescu N, Simionescu M, Palade GE: Permeability of muscle capillaries to small heme-peptides: Evidence for the existence of patent transendothelial channels. J Cell Biol 64: 586–607, 1975 Google Scholar
Bruns RR, Palade GE: Studies on blood capillaries. I. General organization of blood capillaries in muscle. J Cell Biol 37: 244–276, 1968 Google Scholar
Bruns RR, Palade GE: Studies on blood capillaries. II. Transport of ferritin molecules across the wall of muscle capillaries. J Cell Biol 37: 277–299, 1968 Google Scholar
Bundgaard M, Frokjaer-Jensen J, Crone C: Endothelial plasmalemmal vesicles as elements in a system of branching invaginations from the cell surface. Proc Natl Acad Sci USA 76: 6439–6442, 1979 Google Scholar
Crone C: The function of capillaries. Recent Adv in Physiology 10: 125–162, 1984 Google Scholar
Renkin EM, Michel CC (eds): Handbook of Physiology, Section 2 — The Cardiovascular System, Volume IV — Microcirculation. Am Physiological Soc, Bethesda, MD, 1984 Google Scholar
Renkin EM: Multiple pathways of capillary permeability. Circ Res 41: 735–743, 1977 Google Scholar
Duling BR, Berne RM: Longitudinal gradients in periarteriolar oxygen tension. Circ Res 27: 669–678, 1970 Google Scholar
Scow RO, Blanchette-Mackie EJ, Smith LC: Role of capillary endothelium in the clearance of chylomicrons. Circ Res 39: 149–162, 1978 Google Scholar
Taylor AE, Granger DN: Exchange of macromolecules across the microcirculation. In: Renkin EM, Michel CC (eds) Handbook of Physiology — The Cardiovascular System, Section 2, Volume IV, MIcrocirculation, Chapter 11. American Physiology Society, Bethesda, MD, 1984, pp 467–520 Google Scholar
Curry FE: Mechanics and thermodynamics of transcapillary exchange. In: Renkin EM, Michel CC (eds) Handbook of Physiology-The Cardiovascular System, Volume IV, Microcirculation, Chapter 8. American Physiological Soc, Bethesda, MD, 1984, pp 309–374 Google Scholar
Underwood JCE, Carr I: The ultrastructure and permeability characteristics of the blood vessels of a transplantable rat sarcoma. J Pathol 107: 157–166, 1972 Google Scholar
Papadimitriou JM, Woods AE: Structural and functional characteristics of the microcirculation in neoplasms. J Pathol 116: 65, 1975 Google Scholar
Ward JD, Hadfield MG, Becker DP, Lovings ET: Endothelial fenestrations and other vascular alterations in primary melanoma of the central nervous system. Cancer 34: 1982–1991, 1976 Google Scholar
Waggener JD, Beggs JL: Vasculature of neural neoplasma. Adv Neurol 15: 27, 1976 Google Scholar
Kedem O, Katchalsky A: Thermodynamic analysis of the permeability of biological membranes to non-electrolytes. Biochim Biophys Acta 27: 229–245, 1958 Google Scholar
Staverman AJ: The theory of measurement of osmotic pressure. Rec Trav Chim Pays-Bas, 70: 344–352, 1951 Google Scholar
Kedem O, Katchalsky A: A physical interpretation of the phenomenological coefficients of membrane permeability. J Gen Physiol 45: 143–179, 1961 Google Scholar
Patlak CS, Goldstein DA, Hoffman JF: The flow of solute and solvent across a two-membrane system. J Theor Biol 5: 426–442, 1963 Google Scholar
Crone C, Levitt DG: Capillary permeability to small solutes. In: Renkin EM, Michel CC (eds) Handbook of Physiology — The Cardiovascular System, Section 2, Volume IV, Microcirculation, Chapter 10. American Physiological Society, Bethesda, MD, 1984, pp 411–466 Google Scholar
Michel CC: Fluid movements through capillary wall. In: Renkin EM, Michel CC (eds) Handbook of Physiology — The Cardiovascular System, Section 2, Volume IV, Microcirculation, Chapter 9. American Physiological Society, Bethesda, MD, 1984, pp 375–409 Google Scholar
Landis EM, Gibbon Jr JH: The effects of temperature and of tissue pressure on the movement of fluid through the human capillary wall. J Clin Invests 12: 105–138, 1933 Google Scholar
Gore RW, McDonagh PF: Fluid exchange across single capillaries. Annual Rev Physiol 42: 337–357, 1980 Google Scholar
Curry FE, Huxley VH, Sarelius IH: Techniques in the microcirculation: Measurements of permeability, pressure and flow. In: Linden RJ (ed) Techniques in the Life Sciences-Cardiovascular Physiology, Vol. P3/1. Elsevier, New York, 1983, pp 1–34 Google Scholar
Zweifach BW, Intaglietta M: Mechanics of fluid movement across single capillaries in the rabbit. Microvasc Res 1: 83–101, 1968 Google Scholar
Smaje LH, Zweifach BW, Intaglietta M: Micropressures and capillary filtration coefficients in single vessels of the cremaster muscle of the rat. Microvasc Res 2: 96–110, 1970 Google Scholar
Lee JS, Smaje LH, Zweifach BW: Fluid movement in occluded single capillaries of rabbit omentum. Circ Res 28: 358–370, 1971 Google Scholar
Gore RW: Fluid exchange across single capillaries in rat intestinal muscle. Am J Physiol 242 (Heart Circ Physiol) 11: H268-H287, 1982 Google Scholar
Clough G, Smaje LH: Changes in capillary permeability in scurvy. Biorheology 14: 203, 1977 [Abstract] Google Scholar
McDonagh PF, Gore RW: Comparison of hydraulic conductivities in single capillaries of red versus white skeletal muscle. [Abstract]. Microvasc Res 15: 269, 1978 Google Scholar
Frazer PA, Smaje LH, Verrinder A: Microvascular pressure and filtration coefficients in the cat mesentery. J Physiol, London, 283: 439–456, 1978 Google Scholar
Smaje LH, Frazer PA, Clough G: The distensibility of single capillaries and venules in the cat mesentery. Microvasc Res 20: 358–376, 1980 Google Scholar
Michel CC, Mason JC, Curry FE, Tooke JE, Hunter PA: A development of the Landis technique for measuring the filtration coefficient of individual capillaries in the frog mesentery. Q.J. Exp Physiol 59: 283–309, 1974 Google Scholar
Curry FE, Mason JC, Michel CC: Osmotic reflection coefficients of capillary walls to low molecular weight hydrophilic solutes measured in single perfused capillaries of the frog mesentery. J Physiol 261: 319–336, 1976 Google Scholar
Levick JR, Michel CC: A densitometric method for determining the filtration coefficients of single capillaries in the frog mesentery. Microvasc Res 13: 141–151, 1977 Google Scholar
Mason JC, Curry FE, Michel CC: The effects of protein upon the filtration coefficient of individually perfused frog mesenteric capillaries. Microvasc Res 13: 185–202, 1977 Google Scholar
Michel CC: Filtration coefficients and osmotic reflection coefficients of the walls of single frog mesenteric capillaries. J Physiol, London, 309: 355, 1980 Google Scholar
Curry FE: Permeability coefficients of the capillary wall to low molecular weight hydrophilic solutes measured in single perfused capillaries of frog mesentery. Microvasc Res 17: 290–308, 1979 Google Scholar
Curry FE, Frokjaer-Jensen J: Water flow across the walls of single muscle capillaries in the frog, Rana Pipiens. J Physiol 350: 293–307, 1984 Google Scholar
Mellander S, Oberg B, Odelram H: Vascular adjustments to increased transmural pressure in cat and man with special reference to shifts in capillary fluid transfer. Acta Physiol Scand 61: 34–48, 1964 Google Scholar
Sejrsen P, Henriksen O, Paaske WP: Effect of orthostatic blood pressure changes upon capillary filtration-absorption rate in the human calf. Acta Physiol Scand 111: 287–291, 1981 Google Scholar
Folkow B, Mellander S: Measurements of capillary filtration coefficient and its use in studies of the control of capillary exchange. In: Crone C, Lassen NA (eds) Capillary Permeability, Copenhagen: Munksgaard, 1970, p 614–623 (Alfred Benzon Symp. 2) Google Scholar
Richardson PDI, Granger DN, Taylor AE: Capillary filtration coefficient: the technique and its application to the small intestine. Cardiovasc Res 13: 547–561, 1979 Google Scholar
Mortillaro NA, Taylor AE: Interaction of capillary and tissue forces in the cat small intestine. Circ Res 39: 349–358, 1976 Google Scholar
Diana JN, Long SC, Yao H: Effect of histamine on equivalent pore radius in capillaries of isolated dog hind-limb. Microvasc Res 4: 413–437, 1972 Google Scholar
Chen HI, Granger HJ, Taylor AE: Interaction of capillary, interstitial and lymphatic forces in the canine hind paw. Circ Res 39: 245–254, 1976 Google Scholar
Johnson P, Hanson KM: Capillary filtration in the small intestine of the dog. Circ Res 19: 766–773, 1966 Google Scholar
Guyton AC, Lindsey AW: Effects of elevated left atrial pressure and decreased plasma protein concentration on the development of pulmonary edema. Circ Res 7: 649–657, 1959 Google Scholar
Gaar Jr KA, Taylor AE, Owens LJ, Guyton AC: Pulmonary capillary pressure and filtration coefficient in the isolated perfused lung. Am J Physiol 213: 910–914, 1967 Google Scholar
Perl W, Chowdhury P, Chinard FP: Reflection coefficients of dog lung endothelium to small hydrophilic solutes. Am J Physiol 228: 797–809, 1975 Google Scholar
Drake RE, Smith JH, Gabel JC: Estimation of the filtration coefficient in intact dog lungs. Am J Physiol 238: H430-H438, 1980 Google Scholar
Renkin EM, Zaun BD: Effects of adrenal hormones on capillary permeability in perfused rat tissues. Am J Physiol 180: 498–502, 1955 Google Scholar
Rippe B, Kamiya A, Folkow B: Simultaneous measurements of capillary diffusion and filtration exchange during shifts in filtration-absorption and at graded alterations in the capillary permeability surface area product (PS). Acta Physiol Scand 104: 318–336, 1978 Google Scholar
Vargas F, Johnson JA: Permeability of rabbit heart capillaries to nonelectrolytes. Am J Physiol 213: 87–93, 1967 Google Scholar
Nicolaysen G: Increase in capillary filtration rate resulting from reduction in the intravascular calcium ion concentration. Acta Physiol Scand 81: 517–527, 1971 Google Scholar
Wangensteen OD, Lysaker E, Savaryn P: Pulmonary capillary filtration and reflection coefficients in the adult rabbit. Microvasc Res 19: 239–241, 1977 Google Scholar
Fenstermacher JD, Johnson JA: Filtration and reflection coefficients of the rabbit blood-brain barrier. Am J Physiol 211: 341–346, 1966 Google Scholar
Erdmann AJ III, Vaughan Jr TR, Brigham KL, Woolverton WC, Staub NC: Effect of increased vascular pressure on lung fluid balance in unanesthetized sheep. Circ Res 37: 271–284, 1975 Google Scholar
Parker JC, Parker RE, Granger DN, Taylor AE: Vascular permeability and transvascular fluid and protein transport in the dog lung. Circ Res 48: 549–560, 1981 Google Scholar
Vargas F, Johnson JA: An estimate of reflection coefficients for rabbit heart capillaries. J Gen Physiol 47: 667–677, 1964 Google Scholar
Curry FE, Huxley VH, Adamson RH: Permeability of single capillaries to intermediate-sized colored solutes. Am J Physiol 245: H495-H505, 1983 Google Scholar
Vargas FF, Blackshear GL: Transcapillary osmotic flows in the_in vitro_ perfused heart. Am J Physiol, 240 (Heart Circ Physiol, 9): H448-H456, 1981 Google Scholar
Renkin EM, Curry FE: Transport of water and solutes across capillary endothelium. In: Giebisch G, Tosteson DC (eds) Transport Across Biological Membranes: Transport Organs, Berlin: Springer-Verlag, Vol. 4, p 1–45, 1978 Google Scholar
Ballard K, Perl W: Osmotic reflection coefficients of canine subcutaneous adipose tissue endothelium. Microvasc Res 16: 224–236, 1978 Google Scholar
Granger DN, Granger JP, Brace RA, Parker RE, Taylor AE: Analysis of the permeability characteristics of cat intestinal capillaries. Circ Res 44: 335–344, 1979 Google Scholar
Bassingthwaighte JB, Goresky CG: Modeling in the analysis of solute and water exchange in the microvasculature. In: Renkin EM, Michel CG (eds) Handbook of Physiology — The Cardiovascular System, Section 2, Volume IV, Microcirculation, Chapter 13. American Physiological Society, Bethesda, MD, 1984, pp 549–626 Google Scholar
Miles AA, Miles EM: Vascular reactions to histamine, histamine-liberator, and leukotaxine in the skin of guinea pigs. J Physiol 118: 228–257, 1952 Google Scholar
Song CW, Levitt SH: Quantitative study of vascularity in Walker carcinoma 256, Cancer Res 31: 587–589, 1971 Google Scholar
Clement JJ, Song CW, Levitt SH: Changes in functional vascularity and cell number following X-irradiation of a murine carcinoma. Int J Radiation Oncology, Biol Phys 1: 671–678, 1976 Google Scholar
Song CW, Kang MS, Rhee JG, Levitt SH: Effect of hyperthermia on vascular function in normal and neoplastic tissues. Ann NY Acad Sci 335: 35–43, 1980 Google Scholar
Sands H, Shah SA, Gallagher BM: Vascular volume and permeability of human and murine tumors grown in athymic mice. Cancer Lett 27: 15–21, 1985 Google Scholar
Zweifach BW, Lipowsky HH: Pressure-flow relations in blood and lymph microcirculation. In: Renkin EM, Michel CC (eds) Handbook of Physiology-The Cardiovascular System, Volume IV, Microcirculation, Chapter 7. American Physiological Soc, Bethesda, MD, 1984, pp 251–307 Google Scholar
O'Connor SW, Bale WF: Accessibility of circulating immunoglobulin G to the extravascular compartment of solid rat tumors. Cancer Res 44: 3719–3723, 1984 Google Scholar
Fenstermacher JD, Blasberg RG, Patlak CS: Methods for quantifying the transport of drugs across brain barrier systems. Pharmacol Ther 14: 217–248, 1981 Google Scholar
Gullino PM, Grantham FH: Studies on the exchange of fluids between host and tumor. I. A method for growing ‘tissue-isolated’ tumors in laboratory animals. J Natl Cancer Inst 27: 679–693, 1961 Google Scholar
Gullino PM: Techniques for the study of tumor physiopathology. Methods in Cancer Research 5: 45–91, 1970 Google Scholar
Jain RK, Wei J, Gullino PM: Pharmacokinetics of methotrexate in solid tumors. J Pharmacokin Biopharma 7: 181–194, 1979 Google Scholar
Bjork J, Smedegard G, Svensjo E, Arfors KE: The use of the hamster cheek pouch for intravital microscopy studies of microvascular events. Prog Appl Microcirc 6: 41–53, 1984 Google Scholar
Baxter LT, Jain RK, Svensjo E: Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: Effects of vasoactive drugs. Microvasc Res. (in press), 1987
Nugent LJ, Jain RK: Monitoring transport in the rabbit ear chamber. Microvasc Res 24: 204–209, 1982 Google Scholar
Nugent LJ, Jain RK: Plasma pharmacokinetics and interstitial diffusion of macromolecules in a capillary bed. Am J Physiol 246: H129-H137, 1984 Google Scholar
Nugent LJ, Jain RK: Extravascular diffusion in normal and neoplastic tissues. Cancer Res 44: 238–244, 1984 Google Scholar
Gerlowski LE, Jain RK: Microvascular permeability of normal and neoplastic tissues. Microvasc Res 31: 288–305, 1986 Google Scholar
Crone C, Frokjer-Jensen J, Friedman JJ, Christensen O: The permeability of single capillaries to potassium ions. J Gen Physiol 71: 195–220, 1978 Google Scholar
Curry FE, Joyner WL: The effect of histamine, 40/80 and A23187 on albumin permeability in frog venular capillaries. [Abstract]. Fed Proc 45: 1159, 1986 Google Scholar
Hansen AJ, Lund-Andersen H, Crone C: K+-permeability of the blood-brain barrier, investigated by aid of a K+-sensitive microelectrode. Acta Physiol Scand 101: 438–445, 1977 Google Scholar
Olesen SP, Crone C: Electrical resistance of muscle capillary endothelium. Biophys J 42: 31–41, 1983 Google Scholar
Frokjaer-Jensen J: Permeability of single muscle capillaries to potassium ions. Microvasc Res 24: 168–183, 1982 Google Scholar
Joyner WL, Curry FE: Measurement of albumin permeability coefficients in single capillaries of hamster mesentery. [Abstract]. Fed Proc 45: 583, 1986 Google Scholar
Jain RK, Gerlowski LE: Extravascular transport in normal and tumor tissues. CRC Crit Rev Oncology/Hematology 5: 115–170, 1986 Google Scholar
Bassingthwaighte JB, Yipintsoi T, Harvey RB: Microvasculature of the dog left ventricular myocardium. Microvasc Res 7: 229–249, 1974 Google Scholar
Turek Z: Grandtner M, Kreuzer F: Cardiac hypertrophy, capillary and muscle fiber density, muscle fiber diameter, capillary radius and diffusion distance in the myocardium of growing rats, adapted to a simulated altitude of 3500 m. Pfluegers Arch 335: 19–28, 1972 Google Scholar
Metzger H, Heuber-Metzger S, Steinacker A, Struber J: Staining PO2 measurement sites in the rat brain cortex and quantitative morphometry of the surrounding capillaries. Pfluegers Arch 338: 21–27, 1980 Google Scholar
Bar T: The vascular system of the cerebral cortex. In: Brodal A, Hild W, van Limborgh J, Ortmann R, Schiebler TH, Tondury G, Wolff E (eds) Advances in Anatomy, Embryology and Cell Biology, Vol 59, Springer-Verlag, Berlin, 1980 Google Scholar
Pawlik G, Rackl A, Bing RJ: Quantitative capillary topography and blood flow in the cerebral cortex of cats: an_in vivo_ microscopic study. Brain Res 208: 35–58, 1981 Google Scholar
Vimtrup B: On the number, shape, structure and surface area of the glomeruli in the kidneys of man and mammals. Am J Anat 41: 123–151, 1928 Google Scholar
Putter A: Aktive Oberflache und Organfunktion. Z Allg Physiol 12: 125–214, 1911 Google Scholar
Crone C: Does ‘restricted diffusion’ occur in muscle capillaries? Proc Soc Exp Biol Med 112: 453–455, 1963 Google Scholar
Renkin EM, Gilmore JP: Glomerular filtration. In: Hamilton WF, Dow P (eds) Handbook of Physiology: Circulation, American Physiological Soc, Washington D.C., 1973 Google Scholar
Perry MA: Capillary filtration and permeability coefficients calculated from measurements of interendothelial cell junctions in rabbit lung and skeletal muscle. Microvasc Res 19: 142–157, 1980 Google Scholar
Weibel ER: Morphological basis of alveolar-capillary gas exchange. Physiol Rev 53: 419–495, 1973 Google Scholar
Eriksson E, Myrhage R: Microvascular dimensions and blood flow in skeletal muscle. Acta Physiol Scand 86: 211–222, 1972 Google Scholar
Schmid-Schönbein G, Zweifach B, Kovalcheck S: The application of stereological principles to morphometry of the microcirculation in different tissues. Microvasc Res 12: 303–317, 1977 Google Scholar
Casley-Smith JR, Green HS, Harris JL, Wadey PJ: The quantitative morphology of skeletal muscle capillaries in relation to permeability. Microvasc Res 10: 43–64, 1975 Google Scholar
Myrhage R, Hudlicka O: The microvascular bed and capillary surface area in the rat extensor halucis propius muscle (EHP). Microvasc Res 11: 315–323, 1976 Google Scholar
Hilmas D, Gilette EL: Morphometric analyses of the microvasculature of tumors during growth and after X-irradiation. Cancer 33: 103–110, 1974 Google Scholar
Yamaura H, Sato H: Quantitative studies on the developing vascular system of rat hepatoma. J Natl Cancer Inst 53: 1229–1240, 1974 Google Scholar
Rous R, Gilding HP, Smith F: A gradient of vascular permeability. J Exp Med 51: 807–830, 1930 Google Scholar
Ley K, Arfors KE: Segmental differences of microvascular permeability for FITC-dextrans measured in the hamster cheek pouch. Microvasc Res 31: 84–99, 1986 Google Scholar
Dewey WC: Vascular-extravascular exchange of131l plasma proteins in the rat. Am J Physiol 197: 423–431, 1959 Google Scholar
Song CW, Levitt SH: Effect of X-irradiation on vascularity of normal tissues and experimental tumor. Radiology 94: 445–447, 1970 Google Scholar
Peterson HI, Appelgren L, Lundborg G, Rosengren B: Capillary permeability of two transplantable rat tumors as compared with various normal organs of the rat. Bibl Anat 12: 511–518, 1973 Google Scholar
Peterson HI: Vascular and extravascular spaces in tumors: tumor vascular permeability. In: Peterson HI (ed) Tumor Blood Circulation, pp 77–85. Boca Raton, FL: CRC Press, 1979 Google Scholar
Groothuis DR, Fischer JM, Pasternak JF, Blasberg RG, Vick NA, Bigner DD: Regional measurements of blood-to-tissue transport in experimental RG-2 rat gliomas. Cancer Res 43: 3368–3373, 1983 Google Scholar
Blasberg RG, Kobayashi T, Horowitz M, Rice JM, Groothuis D, Molnar P, Fenstermacher JD: Regional blood-to-tissue transport in ethylnitrosourea-induced brain tumors. Ann Neurology 14: 202–215, 1983 Google Scholar
Molnar P, Blasberg RG, Groothuis DG, Bigner D, Fenstermacher JF: Regional blood-to-tissue transport in avian sarcoma virus (AVS)-induced brain tumors. Neurology 33: 702–711, 1983 Google Scholar
Blasberg R, Molnar P, Groothuis D, Patlak CS, Owens E, Fenstermacher J: Concurrent measurements of blood flow and transcapillary transport in avian sarcoma virus-induced experimental brain tumors: Implications for chemotherapy. J Pharmacol Expt Therap 231: 724–735, 1984 Google Scholar
Molnar P, Blasberg RG, Horowitz M, Smith B, Fenstermacher JD: Regional blood-to-tissue transport in RT-g brain tumors. J Neurosurg 58: 874–884, 1983 Google Scholar
Blasberg RG, Shapiro WR, Molnar P, Patlak CS, Fenstermacher JD: Local blood-to-tissue transport in Walker 256 metastatic brain tumors. J Neuro-Oncology 2: 205–218, 1984 Google Scholar
Song CW, Sung JH, Clement JJ, Levitt SH: Vascular changes in neuroblastoma of mice following X-irradiation. Cancer Res 34: 2344–2350, 1974 Google Scholar
Groothuis DR, Fischer JM, Lapin G, Bigner DD, Vick NA: Permeability of different experimental brain tumor models to horseradish peroxidase. J Neuropath Exptl Neurology 41: 164–185, 1982 Google Scholar
Ackerman NB, Hechmer PA: Studies on the capillary permeability of experimental liver metastases. Surg Gynec Obstet 146: 884–888, 1978 Google Scholar
Rutili G: Transport of macromolecules in subcutaneous tissue by FITC-dextrans. Dissertation, Univ. Upsaliensis, Uppsala, Sweden, 1978
Garlick DG, Renkin EM: Transport of large molecules from plasma to interstitial fluid and lymph in dogs. Amer J Physiol 219: 1595–1605, 1970 Google Scholar
Butler TP, Grantham FH, Gullino PM: Bulk transfer of fluid in the interstitial compartment of mammary tumors. Cancer Res 35: 512–516, 1975 Google Scholar
Gullino PM: The internal milieu of tumors. Progr Exp Tumor Res 8: 1–25, 1966 Google Scholar
Misiewicz M: Microvascular and interstitial pressures in normal and neoplastic tissues. M.S. Thesis, Carnegie Mellon University, 1986
Algire GH, Legallais FY: Vascular reactions of normal and malignant tissues_in vivo_. IV. The effect of peripheral hypotension on transplanted tumors. J Natl Cancer Inst 12: 399–421, 1951 Google Scholar
Algire GH: Blood pressure measurements and changes in peripheral vascular bed in unanesthetized mice [Abstract]. Federation Proc 8: 349, 1949 Google Scholar
Algire GH: Determination of peripheral blood pressure in unanesthetized mice during microscopic observation of blood vessels. J Natl Cancer Inst 14: 865–873, 1954 Google Scholar
Ide AD, Baker NH, Warren SH: Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the transparent ear chamber. Am J Roentgenol 42: 891–899, 1939 Google Scholar
Eddy HA, Casarett GW: Development of the vascular system in the hamster malignant neurilemmoma. Microvasc Res 6: 63–82, 1973 Google Scholar
Peters W, Teixeira M, Intaglietta M, Gross JF: Microcirculatory studies in rat mammary carcinoma. I. Transparent chamber method, development of microvasculaturem and pressures in tumor vessels. J Natl Cancer Inst 65: 631–642, 1980 Google Scholar
Young JS, Griffith HD: The dynamics of parenchymatous embolism in relation to the dissemination of malignant tumors. J Pathol Bacteriol 62: 293–311, 1950 Google Scholar
Wiig H: Microvascular pressures in DMBA-induced rat mammary tumors. Scand J Clin Lab Invest 42: 165–171, 1982 Google Scholar
Hori K, Suzuki M, Abe S, Saito S, Sato H: A microocclusion technique for measurement of the microvascular pressure in tumor and subcutis. Japn J Cancer Res (Gann) 74: 122–127, 1983 Google Scholar
Endrich B, Hammersen F: Morphologic and hemodynamic alterations in capillaries during hyperthermia. In: Anghileri CLJ, Robert J (eds) Hyperthermia in Cancer Treatment, Chapter 2. CRC Press, Boca Raton, FL, 1986 Google Scholar
Young JS, Lumsden CE, Stalker AL: The significance of the ‘tissue pressure’ of normal testicular and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit. J Path Bact 62: 313–333, 1950 Google Scholar
Wiig H, Tveit E, Hultborn R, Reed RK, Weiss L: Interstitial fluid pressure in DMBA-induced rat mammary tumors. Scand J Clin Lab Invest 42: 159–164, 1982 Google Scholar
Paskins-Hurlburt AJ, Hollenberg NK, Abrams HL: Tumor perfusion in relation to the rapid growth phase and necrosis: Studies on the Walker carcinoma in the rat testicle. Microvasc Res 24: 15–24, 1982 Google Scholar
Hori K, Suzuki M, Abe I, Saito S: Increased tumor pressure in association with the growth of rat tumors. Japan J Cancer Res (Gann) 77: 65–73, 1986 Google Scholar
Misiewicz M, Jain RK: Interstitial pressure gradients in VX2 carcinoma. In preparation, 1987
Chary SR, Jain RK: Analysis of diffusive and convective recovery of fluorescence after photobleaching — Effect of uniform flow field. Chemical Engineering Communications (in press), 1987
Potchen EJ, Kinzie J, Curtis C, Siegel BA, Studer RK: Effect of irradiation on tumor microvascular permeability to macromolecules. Cancer 30: 639–642, 1972 Google Scholar
Song CW, Levitt SH: Vascular changes in Walker 256 carcinoma of rats following irradiation. Radiology 100: 397–407, 1971 Google Scholar
Hahn GM: Hyperthermia and Cancer. Plenum Press, New York, 1982 Google Scholar
Jain RK, Gullino PM (eds): Thermal Characteristics of Tumors: Applications in Detection and Treatment. Annals of the New York Academy of Sciences 335, 1980
Sevitt S: Early and delayed edema and increases in capillary permeability after burns of the skin. J Pathol Bact 75: 27–37, 1958 Google Scholar
Wilhelm DL, Mason B: Vascular permeability changes in inflammation: The role of endogenous permeability factors in mild thermal injury. Br J Exp Pathol 61: 487–506, 1960 Google Scholar
Cotran RS, Remensnyder JP: The structural basis of increased vascular permeability after graded thermal injury - light and electron microscopic studies. Ann N.Y. Acad Sci 150: 495–509, 1968 Google Scholar
Arturson G: Microvascular permeability to macromolecules in thermal injury. Acta Physiol Scand Suppl 463: 111–112, 1979 Google Scholar
Ackerman NB, Makohon S: The effects of cooling, freezing, and thawing on vascular permeability and perfusion in experimental liver metastases. Surg Gynec Obstet 152: 262–267, 1981 Google Scholar
Lefor AT, Makohon S, Ackerman NB: The effects of hyperthermia on vascular permeability in experimental liver metastasis. J Surg Oncol 28: 297–300, 1981 Google Scholar
Gerlowski LE, Jain RK: Effect of hyperthermia on microvascular permeability of normal and neoplastic tissues. Intl J Microcirc: Clinical and Expt 4: 336–372, 1985 Google Scholar
Svensjö E, Joyner WL: The effects of intermittant and continuous stimulation of microvessels in the cheek pouch of hamsters with histamine and bradykinin on the development of venular leaky sites. J Microcirc Endothel Lymphat 1: 381, 1984 Google Scholar
Senger DR, Galli SJ, Dvorak AM, Peruzzi CA, Harvery VS, Dvorak HF: Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219: 983–985, 1983 Google Scholar
Senger DR, Peruzzi CA, Feder J, Dvorak HF: A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res 46: 5629–5632, 1986 Google Scholar
Ackerman NB, Hechmer PA, Makohon S: Failure of histamine type mediators to enhance vascular permeability in experimental liver metastasis. Surg Gynec Obstet 151: 647–651, 1980 Google Scholar
Jain RK, Shah SA, Finney PL: Continuous non-invasive monitoring of pH and temperature in rat Walker 256 carcinoma during normo-and hyperglycemia. J Natl Cancer Inst 73: 429–436, 1984 Google Scholar
Ward-Hartley K, Jain RK: Effect of glucose and galactose on microcirculatory flow in normal and neoplastic tissues in rabbits. Cancer Res 47: 371–377, 1987 Google Scholar
Ward KA, Jain RK: Physiological response on tumors to hyperglycemia: Characterization, significance, and role in hyperthermia. International Journal of Hyperthermia, (in press)