The cytokine network in the pathogenesis of systemic lupus erythematosus and possible therapeutic implications (original) (raw)
References
Aderka D, Engelmann H, Maor Y, Brakebusch C, Wallach D (1992) Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. J Exp Med 175:323 Google Scholar
Aderka D, Wysenbeek A, Engelmann H, et al (1993) Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus. Arthritis Rheum 36:1111 Google Scholar
Alcocer-Varela J, Alarcon-Segovia D (1982) Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus. J Clin Invest 69:1388 Google Scholar
Alcocer-Varela J, Aleman-Hoey D, Alarcon-Segovia D (1992) Interleukin-I and interleukin-6 activities are increased in the cerebrospinal fluid of patients with CNS lupus erythematosus and correlate with local late T-cell activation markers. Lupus 1:111 Google Scholar
Alcocer-Varela J, Laffon A, Alarcon-Segovia D (1983) Defective monocyte production of, and T lymphocyte response to, interleukin-1 in the peripheral blood of patients with systemic lupus erythematousus. Clin Exp Immunol 54:125 Google Scholar
al Janadi M, al-Balla S, al-Dalaan A, Raziuddin S (1983) Cytokine profile in systemic lupus erythematousus, rheumtoid arthritis, and other rheumatic diseases. J Clin Immunol 13:58 Google Scholar
Alleva DG, Burger CJ, Elgert KD (1993) Tumor-induced macrophage tumor necrosis factor-alpha production suppresses autoreactive T cell proliferation. Immunobiology 188:430 Google Scholar
Aotsuka S, Nakamura K, Nakano T, Kawakami M, Goto M, Okawa-Takatsuji M, Kinoshita M, Yokohari R (1991) Production of intracellular and extracellular interleukin-1 alpha and interleukin-1 beta by peripheral blood monocytes from patients with connective tissue diseases. Ann Rheum Dis 50:27 Google Scholar
Babcock SK, Appel VB, Schiff M, Palmer E, Kotzin BL (1989) Genetic analysis of the imperfect association of H-2 haplotype with lupus-like autoimmune disease. Proc Natl Acad Sci USA 86:7552 Google Scholar
Beutler B, Krochin N, Milsark IW, Luedke C, Cerami A (1986) Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science 232:977 Google Scholar
Bizar-Scheebaum A, O'Dell JR, Kotzin BL (1987) Anti-histone antibody production by peripheral blood cells in SLE. Arthritis Rheum 30:511 Google Scholar
Boswell JM, Yui MA, Burt DW, Kelley VE (1988) Increased tumor necrosis factor and IL-1_β_ gene expression in the kidneys of mice with lupus nephritis. J Immunol 141:3050 Google Scholar
Bottazzo GF, Pujol Borrel R, Hanafusa T (1983) Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet II:1115 Google Scholar
Brennan DC, Yui MA, Wuthrich RP, Kelley VE (1989) Tumor necrosis factor and IL-1 in New Zealand black/white mice. J Immunol 143:3470 Google Scholar
Campen DH, Horwitz DA, Quismorio FQ Jr, Ehresmann GR, Martin WJ (1988) Serum levels of interleukin-2 receptor and activity of rheumatic disease characterized by immune system activation. Arthritis Rheum 31:1358 Google Scholar
Casciola-Rosen LA, Anhalt G, Rosen A (1994) Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 179:1317 ArticleCASPubMed Google Scholar
Chang RJ, Lee SH (1986) Effects of interferon-γ and tumor necrosis factor-α on the expression of an ia antigen on a murine macrophage cell line. J Immunol 137:2853 Google Scholar
Chu EB, Ernst DN, Hobbs MV, Weigle WO (1994) Maturational changes in CD4+ cell subsets and lymphokine production in BXSB mice. J Immunol 152:4129 Google Scholar
Cosman D (1993) The hematopoietin receptor superfamily. Cytokine 5:95 Google Scholar
Del Guidice G, Crow MK (1993) Role of transforming growth factor beta in systemic autoimmunity. Lupus 2:213 Google Scholar
Dunham I, Sargent CA, Trowsdale J, Campbell DR (1987) Molecular mapping of the human major histocompatibility complex by pulse field gel electrophoresis. Proc Natl Acad Sci USA 84:7237 Google Scholar
Ehlers MR, Riordan JF (1991) Membrande proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins. Biochem 30:10065 Google Scholar
Engelman EG, Sonnenfeld G, Dauphinee M, Greenspan JS, Talal N, McDevitt HO, Merigan TC (1981) Treatment of NZB/NZW F1 mice with Mycobacterium Bovis strain BCG or type II interferon preparations accelerates autoimmune disease. Arthritis Rheum 24:1396 Google Scholar
Engelmann H, Holtmann H, Brakebusch C, Avni YS, Sarov I, Nophar Y, Hadas E, Leitner O, Wallach D (1990) Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity. J Biol Chem 265:14497 Google Scholar
Falk LA, Wahl LM, Vogel SN (1988) Analysis of Ia antigen expression in macrophages derived from bone marrow cells cultured in granulocyte-macrophages colony-stimulating factor or macrophage colony-stimulating factor. J Immunol 140:2652 Google Scholar
Fargeas C, Wu CY, Nakajima T, Cox D, Nutman T, Delespesse G (1992) Differential effect of transforming growth factor beta on the synthesis of Th1- and Th2-like lymphokines by human T lymphocytes. Eur J Immunol 22:2173 Google Scholar
Fronek Z, Timmerman LA, Alper CA, Hahn BH, Kalunian K, Peterlin BM, McDevitt HO (1990) Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus. Arthritis Rheum 33:1542 Google Scholar
Funacuchi M, Sugishima H, Minoda M, Horiuchi A (1991) Effect of interferon-gamma on B lymphocyte of patients with systemic lupus erythematosus. J Rheumatol 18:368 Google Scholar
Funauchi M, Minoda M, Horiuchi A (1991) Qualitative difference of anti-DNA antibody-producing cell precursors in the pre-immune B cell repertoire between normal and lupus-prone mice. Clin Exp Immunol 86:106 Google Scholar
Gabay C, Roux-Lombard P, de Moerloose P, Dayer JM, Vischer T, Guerne PA (1993) Absence of correlation between interleukin 6 and C-reactive protein blood levels in systemic lupus erythematousus compared with rheumatoid arthritis. J Rheumatol 20:815 Google Scholar
Geiser AG, Letterio JJ, Kulkarni AB, Karlsson S, Roberts AB, Sporn MB (1993) Transforming growth factor-beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta I null mouse phenotype. Proc Natl Acad Sci USA 90:9944 Google Scholar
Gharavi AE, Chu J, Elkon KB (1988) Autoantibodies to intracellular proteins in human systemic lupus erythematousus are not due to random polyclonal B cell activation. Arthritis Rheum 1:1337 Google Scholar
Golbus J, Salata M, Greenwood J, Hudson J, Richardson BC (1988) Increased immunoglobulin response to gamma-interferon by lymphocytes from patients with systemic lupus erythematosus. Clin Immunol Immunopathol 46:129 Google Scholar
Gordon C, Emery P (1993) Cytokines and the acute phase response in SLE. Lupus 2:345 Google Scholar
Gordon C, Wofsy D (1990) Effects of recombinant murine tumor necrosis factor-α on immune function. J Immunol 144:1753 Google Scholar
Gordon C, Ranges GE, Greenspan JS, Wofsy D (1989) Chronic therapy with recombinant tumor necrosis factor-α in autoimmune NZB/NZW F1 mice. Clin Immunol Immunopathol 52:42 Google Scholar
Gordon C, Richards N, Howie AJ, et al. (1991) Urinary IL-6: a marker for mesangial proliferative glomerulonephritis. Clin Exp Immunol 86:145 Google Scholar
Gottlieb AB, Lahita RG, Chiorazzi N, Kunkel HG (1979) Immune function in systemic lupus erythematosus. Impairment of in vitro T-cell proliferation and in vivo antibody response to exogenous antigen. J Clin Invest 63:885 Google Scholar
Graninger WB, Hassfeld W, Pesau BB, Machold KP, Zielinski CC, Smolen JS (1991) Induction of systemic lupus erythematousus by interferon-gamma in a patient with rheumatoid arthritis. J Rheumatol 18:1621 Google Scholar
Gray JD, Hirokawa M, Horwitz DA (1994) The role of transforming growth factor beta in the generation of suppression: an interaction between CD8+ T cells and NK cells, (in press)
Gutierrez-Ramos JC, Andreu JL, Revilla Y, Vineula E, Martinez C (1990) Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus. Nature 346:271 Google Scholar
Gutierrez-Ramos JC, Andreu JL, Marcos MA, Vegazo IR, Martinez C (1991) Treatment with IL-2/vaccinia recombinant virus leads to serologic, histologic and phenotypic normalization of autoimmunity MRL/lpr-lpr mice. Autoimmunity 10:15 Google Scholar
Hayakawa K, Hardy RR, Honda M, Herzenberg LA, Steinberg AD, Herzenberg LA (1984) Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proc Natl Acad Sci USA 81:2494 Google Scholar
Hefeneider SH, Cornell KA, Brown LE, Bakke AC, McCoy SL, Bennett RM (1992) Nucleosomes and DNA bind to specific cell-surface molecules on murine cells and induce cytokine production. Clin Immunol Immunopathol 63:245 Google Scholar
Hefeneider SH, Brown LE, McCoy SL, Bakke AC, Cornell KA, Bennett RM (1993) Immunization of BALB/c mice with a monoclonal anti-DNA antibody induces an anti-idiotypic antibody reactive with a cell-surface DNA binding protein. Autoimmunity 15:187 Google Scholar
Hirohata S, Miyamoto T (1990) Elevated levels of interleukin-6 in cerebrospinal fluid from patients with systemic lupus erythematosus and central nervous system involvement. Arthritis Rheum 33:644 Google Scholar
Hirokawa M, Gray JD, Takahashi T, Horwitz DA (1992) Human resting B lymphocytes serve as accessory cells for anti-CD2 induced T cell activation. J Immunol 149:1859 Google Scholar
Hirose T (1989) Spontaneous production of interleukin-1 and B cell stimulating factors by B cells from patients with systemic lupus erythematousus. Ryumachi 29:277 Google Scholar
Hoffman M, Weinberg JB (1987) Tumor necrosis factor-α induces increased hydrogen peroxide production and Fc receptor expression, but not increased Ia antigen expression by peritoneal macrophages. J Leukoc Biol 42:704 Google Scholar
Horwitz DA (1992) Systemic lupus erythematousus: generalized autoimmunity resulting from disordered immune regulation In: McCarty DJ, (ed) Arthritis and allied conditions 12th edn. Lea & Febiger, Philadelphia, pp 1185–1200 Google Scholar
Horwitz DA, Wang H (1994) Cytokine gene profile in circulating blood mononuclear cells from patients with systemic lupus erythematousus: increased interleukin-2 but not interleukin 4 mRNA. Lupus 3:423 Google Scholar
Huang FP, Stott DI (1993) Restoration of an early, progressive defect in responsiveness to T cell activation in lupus mice by exogenous IL-2. Autoimmunity 15:19 Google Scholar
Huang YP, Miescher PA, Zubler RH (1986) The interleukin 2 secretion defect in vitro in systemic lupus erythematousus is reversible in rested cultured T cells. J Immunol 137:3515 Google Scholar
Huang YP, Perrin LH, Miescher PA, Zubler RH (1988) Correlation of T and B cell activities in vitro and serum IL-2 levels in systemic lupus erythematosus. J Immunol 141:827 Google Scholar
Ishida H, Kumagai S, Umehara H, Sano H, Tagaya Y, Yodoi J, Imura H (1987) Impaired expression of high affinity interleukin 2 receptor on activated lymphocytes from patients with systemic lupus erythematousus. J Immunol 139:1070 Google Scholar
Ishida H, Hastings R, Kearney J, Howard M (1992) Continuous anti-interleukin 10 antibody administration depletes mice of Ly-1 cells but not conventional B cells. J Exp Med 175:1213 Google Scholar
Ishida H, Hastings R, Thompson-Snipes L, Howard M (1993) Modified immunological status of anti-IL-10 treated mice. Cell Immunol 148:371 Google Scholar
Ishida H, Muchamuel T, Sakaguchi S, Andrade S, Menon S, Howard M (1994) Continuous administration of anti-interleukin-10 antibodies delays onset of autoimmunity in NZB/W F1 mice. J Exp Med 179:305 Google Scholar
Jacob CO (1992) Studies on the role of tumor necrosis factor in murine and human autoimmunity. J Autoimmune 5:133 Google Scholar
Jacob CO, McDevitt HO (1988) Tumor necrosis factor-α in murine autoimmune “lupus” nephritis. Nature 331:356 Google Scholar
Jacob CO, McDevitt HO (1991) Interferon gamma and tumor necrosis factor in autoimmune disease models: implications for immunoregulation and genetic susceptibility. In Talal N (ed) Molecular autoimmunity. Academic Press, New York, pp 107–126 Google Scholar
Jacob CO, Van Der Meide PH, McDevitt HO (1987) In vivo treatment of (NZB x NZW)F1 lupus-like nephritis with monoclonal antibody to γ-interferon. J Exp Med 166:798 Google Scholar
Jacob CO, Fronek Z, Lewis GD, Koo M, Hansen JA, McDevitt HO (1990) Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor-α: relevance to genetic predisposition to systemic lupus erythematosus. Proc Natl Acad Sci USA 87:1233 Google Scholar
Jacob CO, Lewis GD, McDevitt HO (1991) MHC class II associated variation in the production of tumor necrosis factor in mice and humans: relevance to the pathogenesis of autoimmune diseases. Immunol Res 10:156 Google Scholar
Jacob CO, Hwang F, Lewis GD, Stall AM (1992) Tumor necrosis factor-α in murine systemic lupus erythematosus disease models: implications for genetic predisposition and immune regulation. Cytokine 3:551 Google Scholar
Jandl RC, George JL, Silberstein DS, Eaton RB, Schur PH (1987) The effect of adherent cell-derived factors on immunoglobulin and anti-DNA synthesis in systemic lupus erythematosus. Clin Immunol Immunopathol 42:344 Google Scholar
Jongeneel CV, Acha-Orbea H, Blankenstein T (1990) A polymorphic microsatellite in the tumor necrosis factor α promoter identifies an allele unique to the NZW mouse strain. J Exp Med 171:2141 Google Scholar
Kanayama Y, Kim T, Inariba H, Necoro N, Okamura M, Takeda T, Inoe T (1989) Possible involvement of interferon alpha in the pathogenesis of fever in systemic lupus erythematosus. Ann Rheum Dis 48:86 Google Scholar
Kekow J, Wachsman W, McCutchan JA, Cronin M, Carson DA, Lotz M (1990) Transforming growth factor beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection. Proc Natl Acad Sci USA 87:8321 Google Scholar
Kim T, Kanayama Y, Okamura M, Takeda T, Inoue T (1987) Serum levels of interferons in patients with systemic lupus erythematousus. Clin Exp Immunol 70:562 Google Scholar
Kitani A, Hara M, Hirose T, Harigai M, Suzuki K, Kawakami M, Kawaguchi Y, Hidaka T, Kawagoe M, Nakamura H (1992) Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematousus: analysis of IL-6 production and IL-6R expression. Clin Exp Immunol 88:75 Google Scholar
Klashman DJ, Martin RA, Martinez-Maza O, Stevens RH (1991) In vitro regulation of B cell differentiation by interleukin-6 and soluble CD23 in systemic lupus erythematosus B cell subpopulations and antigen-induced normal B cells. Arthritis Rheum 34:276 Google Scholar
Knight JG, Adams DD (1978) Three genes for lupus nephritis in NZB x NZW mice. J Exp Med 147:1653 Google Scholar
Kotzin BL, Palmer ED (1987) The contribution of NZW genes to lupus-like disease in (NZB x NZW)F1 mice. J Exp Med 165:1237 Google Scholar
Laut J, Senitzer D, Petrucci R, Sablay LB, Barland P, Glicklich D (1992) Soluble interleukin-2 receptor levels in lupus nephritis. Clin Nephrol 38:179 Google Scholar
Leeuwenberg JFM, van Damme J, Meager T, Jeunhomme TMAA, Buurman WA (1988) Effects of tumor necrosis factor on the interferon-γ induced major histocompatibility complex class II antigen expression by human endothelial cells. Eur J Immunol 18:1469 Google Scholar
Linker-Israeli M, Bakke AC, Kitridou RC, Gendler S, Gillis S, Horwitz DA (1983) Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE). J Immunol 130:265 Google Scholar
Linker-Israeli M, Bakke AC, Quismorio FP Jr, Horwitz DA (1985) Correction of interleukin-2 production in patients with systemic lupus erythematousus by removal of spontaneously activated suppressor cells. J Clin Invest 75:762 Google Scholar
Linker-Israeli M, Quismorio FP Jr, Horwitz DA (1990) CD8+ lymphocytes from patients with systemic lupus erythematousus lymphocytes sustain rather than suppress spontaneous polyclonal IgG production and synergize with CD4+ cells to support autoantibody synthesis. Arthritis Rheum 33:1216 Google Scholar
Linker-Israeli M, Deans RJ, Wallace DJ, Prehn J, Ozeri-Chen T, Klinenberg JR (1991) Elevated levels of endogenous IL-6 in systemic lupus erythematousus. A putative role in pathogenesisb. J Immunol 147:117 CASPubMed Google Scholar
Llorente L, Richaud-Patin Y, Wijdenes J, Alcocer-Varela J, Maillot MC, Durand-Gasselin I, Fourrier BM, Galanaud P, Emile D (1993) Spontaneous production of interleukin-10 by B lymphocytes and monocytes in systemic lupus erythematosusb. Eur Cytokine Netw 4:421 Google Scholar
Loughlin AJ, Woodroofe MN, Cuzner ML (1993) Modulation of interferon-gamma-induced major histocompatibility complex class II and Fc receptor expression on isolated microglia by transforming growth factor-beta 1, interleukin-4, noradrenaline and glucocorticoids. Immunology 79:125 Google Scholar
Lust JA, Donovan KA, Kline MP, Greipp PR, Kyle RA, Maihle NJ (1992) Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine 4:96 Google Scholar
Machold KP, Smolen JS (1990) Interferon-gamma induced exacerbation of systemic lupus erythematosus. J Rheumatol 17:831 Google Scholar
Malave I, Searles RP, Montano J, Williams RC Jr (1989) Production of tumor necrosis factor/cachetin by peripheral blood mononuclear cells in patients with systemic lupus erythematosus. Int Arch Allergy Appl Immunol 89:355 Google Scholar
Malygin AM, Meri S, Timonen T (1993) Regulation of natural killer cell activity by transforming growth factor-beta and prostaglandin E2. Scand J Immunol 37:71 Google Scholar
Manoussakis MN, Papadopoulos GK, Drosos AA, Moutsopoulos HM (1989) Soluble interleukin 2 receptor molecules in the serum of patients with autoimmune diseases. Clin Immunol Immunopathol 50:321 Google Scholar
Matei I, Ghyka G, Savi I, Tudor A (1990) Correlation of serum interferon with some clinical and humoral signs of systemic lupus erythematousus. Med Interne 28:289 Google Scholar
Maury CPJ, Teppo AM (1989) Tumor necrosis factor in the serum of patients with systemic lupus erythematosus. Arthritis Rheum 32:146 Google Scholar
Meijer C, Huysen V, Smeenk RTJ, Swaak AJG (1993) Profiles of cytokines (TNF-α and IL-6) and acute phase proteins (CRP and α1 AG) related to the disease course in patients with systemic lupus erythematosus. Lupus 2:359 Google Scholar
Metsarinne KP, Nordstrom CDe, Konttinen YT, Tepp AM, Fyhrquist FY (1992) Plasma interleukin-6 and renin substrate in reactive arthritis, rheumatoid arthritis and systemic lupus erythematosus. Rheumatol Int 12:93 Google Scholar
Miyagi J, Minato N, Sumiya M, Kasahara T, Kano S (1989) Two types of antibodies inhibiting interleukin-2 production by normal lymphocytesin patients with systemic lupus erythematosus. Arthritis Rheum 32:1356 Google Scholar
Miyasaka N, Nakamura T, Russell IJ, Talal N (1984) Interleukin-2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus. Clin Immunol Immunopathol 31:109 Google Scholar
Morris SC, Cheek RL, Cohen PL, Eisenberg RA (1990) Autoantibodies in chronic graft versus host result from cognate T-B interactions. J Exp Med 171:503 Google Scholar
Mosmann TR, Coffman RL (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145 Google Scholar
Mullberg J, Dittrich E, Graeve L, Gerhartz C, Yasukawa K, Taga T, Kishimoto T, Heinrich PC, Rose-John S (1993) Differential shedding of the two subunits of the interleukin-6 receptor. FEBS Lett 332:174 Google Scholar
Mullberg J, Schooltink H, Stoyan T, Gunther M, Graeve L, Buse G, Mackiewicz A, Heinrich PC, Rose-John S (1993) The soluble interleukin-6 receptor is generated by shedding. Eur J Immunol 23:473 CASPubMed Google Scholar
Muller U, Jongeneel CV, Nedospasov SA, Lindahl KF, Steinmetz M (1987) Tumor necrosis factor and lymphotoxin genes map close to H-2D in mouse major histocompatibility complex. Nature 325:265 Google Scholar
Murakawa Y, Takada S, Yueda Y, Suzuki N, Hoshino T, Sakane T (1985) Characterization of T lymphocyte subpopulations responsible for deficient interleukin-2 activity in patients with systemic lupus erythematousus. J Immunol 134:187 Google Scholar
Murphy ED, Roths JB (1979) A Y-chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum 22:1188 Google Scholar
Nagafuchi H, Suzuki N, Mizushima Y, Sakane T (1993) Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus. J Immunol 151:6525 Google Scholar
Nagai H, Sztein MB, Steeg PS, Hooks JJ, Oppenheim JJ, Steinberg AD (1984) Diminished peripheral blood monocyte DR antigen expression in systemic lupus erythematosus. Clin Exp Rheumatol 2:131 Google Scholar
Naiki M, Chiang BL, Cawley D, Ansari A, Rozzo SJ, Kotzin BL, Zlotnik A, Gershwin ME (1992) Generation and characterization of cloned T helper cell lines for anti-DNA responses in NZB. H-2bm12 mice. J Immunol 149:4109 Google Scholar
Nelson BJ, Ralph P, Green SJ, Nacy CA (1991) Effect of transforming growth factor-beta on early and late activation events in human T cells. J Immunol 146:1849 Google Scholar
Nelson DL, Rubin LA, Kurmann CC, Fritz ME, Boutin B (1986) An analysis of the cellular requirements for the production of soluble interleukin-2 receptors in vitrob. J Clin Immunol 6:114 Google Scholar
Novick D, Engelmann H, Wallach D, Rubinstein M (1989) Soluble cytokine receptors are present in normal human urine. J Exp Med 170:1409 Google Scholar
O'Garra A, Murphy K (1993) T-cell subsets in autoimmunity. Curr Opin Immunol 5:880 Google Scholar
Owen KL, Shibata T, Izui S, Walker SE (1989) Recombinant interleukin-2 therapy of systemic lupus erythematousus in the New Zealand black/New Zealand white mouse. J Biol Resp Modif 8:366 Google Scholar
Patton JS, Shepard MH, Wilking H, Lewis GD (1986) Interferons and tumor necrosis factor have similar catabolic effects on 3T3 L1 cells. Proc Natl Acad Sci USA 83:8313 Google Scholar
Pelton BK, Speckmaier M, Hylton W, Farrant J, Denman AM (1991) Cytokine-independent progression of immunoglobulin production in vitro by B lymphocytes from patients with systemic lupus erythematousus. Clin Exp Immunol 83:274 Google Scholar
Pelton BK, Hylton W, Denman AM (1992) Activation of IL-6 production by UV irradiation of blood mononuclear cells from patients with systemic lupus erythematosus. Clin Exp Immunol 89:251 Google Scholar
Pfizenmaier K, Scheurich P, Schluter C, Kronke M (1987) Tumor necrosis factor enhances HLA-A, B, C and HLA DR gene expression in human tumor cells. J Immunol 138:975 Google Scholar
Preble OT, Black RJ, Friedman RM, Klippel J, Vilcek J (1982) Systemic lupus erythematosus: presence in human serum of unusual acid labile leukocyte interferon. Science 216:429 Google Scholar
Ragousis J, Bloemer K, Weiss EH, Ziegler A (1988) Localization of the genes for tumor necrosis factor and lymphotoxin between the HLA class I and Class III regions by field inversion gel electrophoresis. Immunogenetics 27:66 Google Scholar
Raveche ES, Steinberg AD, Klassen KW, Tijo JH (1978) Genetic studies in NZB mice. J Exp Med 147:1487 Google Scholar
Raz E, Watanabe A, Baird SM, Eisenberg RA, Parr TB, Lotz M, Kipps TJ, Carson DA (1993) Systemic immunological effects of cytokine genes injected into skeletal muscle. Proc Natl Acad Sci USA 90:4523 Google Scholar
Remick DG, Nguyen DT, Eskandari MK, Strieter RM, Kunkel SL (1989) Cyclosporine-A inhibits TNF production without decreasing TNF messenger RNA levels. Biochem Biophys Res Commun 161:551 Google Scholar
Rizzo LV, DeKruyff RH, Umetsu DT (1992) Generation of B cell memory and affinity maturation. Induction with Th1 and Th2 T cell clones. J Immunol 148:3733 Google Scholar
Roennblom LE, Alm GV, Oberg K (1991) Autoimmune phenomena in patients with malignant carcinoid tumors during interferon-alpha treatment. Acta Oncol 30:537 Google Scholar
Schlling PJ, Jurzrock R, Kantarjian H, Guttterman JU, Talpaz M (1991) Development of systemic lupus erythematousus after interferon therapy for chronic myelogenous leukemia. Cancer 68:1536 Google Scholar
Seckinger P, Isaaz S, Dayer JM (1989) Purification and biologic characterization of a specific tumor necrosis factor alpha inhibitor. J Biol Chem 264:11966 Google Scholar
Semenzato G, Bambara LM, Biasi D, Frigo A, Vinante F, Zuppini B, Trentin L, Feruglio C, Chilosi M, Pizzolo G (1988) Increased serum levels of soluble interleukin-2 receptor in patients with systemic lupus erythematousus and rheumatoid arthritis. J Clin Immunol 8:447 Google Scholar
Sher A, Gazzinelli RT, Oswald IP, Clerici M, Kullberg M, Pearce EJ, Berzofsky JA, Mosmann TR, James SL, Morse HC (1992) Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. Immunol Rev 127:183 Google Scholar
Shiozawa S, Kuroki Y, Kim M, Hirohata S, Ogino T (1992) Interferon-alpha in lupus psychosis. Arthritis Rheum 35:417 Google Scholar
Shirakawa F, Yamashita U, Suzuki H (1985) Decrease in HLA-DR monocytes in patients with SLE. J Immunol 134:3560 Google Scholar
Sierakowski S, Kucharz EJ, Lightfoot RW Jr, Goodwin JS (1987) Interleukin-1 production by monocytes from patients with systemic lupus erythematousus. Clin Rheum 6:403 Google Scholar
Sims JE, Gayle MA, Slack JL, et al (1993) Interleukin 1 signaling occurs exclusively via the type I receptor. Proc Natl Acad Sci USA 90:6155 Google Scholar
Spronk PE, ter Borg EJ, Limburg PC, Kallenberg CGM (1992) Plasma concentration of IL-6 in systemic lupus erythematousus. Clin Exp Immunol 90:106 Google Scholar
Stall AM, Farinas MC, Tarlinton DM, Lalor PA, Herzenberg LA, Strober S, Herzenberg LA (1988) Ly-1 B cell clones similar to human chronic lymphocytic leukemias routinely develop in older mice and young autoimmune (New Zealand Blackrelated) animals. Proc Natl Acad Sci USA 85:7312 Google Scholar
Steinberg AD, Kreig AM, Gourley MF, Klinman DM (1990) Theoretical and experimental approaches to generalized autoimmunity. Immunol Rev 118:129 Google Scholar
Stohl W (1992) Impaired generation of polyclonal T cell-mediated cytolytic activity despite normal polyclonal T cell proliferation in systemic lupus erythematousus. Clin Immunol Immunopathol 63:163 Google Scholar
Stolzenburg T, Binz H, Fontana A, Felder M, Wagenhaeuser FJ (1988) Impaired mitogen-induced interferon-gamma production in rheumatoid arthritis and related diseases. Scand J Immunol 27:73 Google Scholar
Tada T, Ohzeki S, Utsumi K, Takiuchi H, Muramatsu M, Li XF, Shimizu J, Fujiwara H, Hamaoka T (1991) Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state. J Immunol 146:1077 Google Scholar
Tanaka T, Saiki O, Negoro S, Igarashi T, Kuritani T, Hara H, Suemura M, Kishimoto S (1989) Decreased expression of intererleukin-2 binding molecules (p70/75) in T cells from patients with systemic lupus erythematousus. Arthritis Rheum 32:552 Google Scholar
Tanaka Y, Saito K, Shirakawa F, Ota T, Suzuki H, Eto H, Yamashita U (1988) Production of B cell-stimulating factors by B cells in patients with systemic lupus erythematosus. J Immunol 141:3043 Google Scholar
Tanaka Y, Saito K, Suzuki H, Eto H, Yamashita U (1989) Inhibitory effect of anti-class II antibody on the spontaneous activation of B cells in patients with systemic lupus erythematousus. Analysis with IL-1 production and IL-1 receptor expression. J Immunol 143:1584 Google Scholar
ter Borg EJ, Horst G, Limburg PC, Kallenberg CGM (1990) Changes in plasma levels of interleukin 2 receptor in relation to disease exacerbations and levels of anti-dsDNA and complement in systemic lupus erythematousus. Clin Exp Immunol 82:21 Google Scholar
Theofilopoulos AN, Dixon FJ (1985) Murine models of systemic lupus erythematosus. Adv Immunol 37:269 Google Scholar
Tsokos GC, Rook AH, Djeu JY, Balow JE (1982) Natural killer cells and interferon responses in patients with systemic lupus erythematousus. Clin Exp Immunol 5:239 Google Scholar
Tsokos GC, Boumpas DT, Smith PL, Djeu JY, Balow JE, Rook AH (1986) Deficient gamma-interferon production in patients with systemic lupus erythematosus. Arthritis Rheum 29:1210 Google Scholar
Via CS, Tsokos GC, Bermas B, Clerici M, Shearer GM (1993) T cell-antigen-presenting cell interactions in human systemic lupus erythematousus. Evidence for heterogeneous expression of multiple defects. J Immunol 151:3914 Google Scholar
Von Wussow P, Jakschies D, Hartung K, Deicher H (1988) Presence of interferon and anti-interferon in patients with systemic lupus erythematosus. Rheumatol Int 8:225 Google Scholar
Warrington RJ, Rutherford WJ (1990) Normal mitogen-induced suppression of the interleukin-6 response and its deficiency in systemic lupus erythematosus. J Clin Immunol 10:52 Google Scholar
Watanabe Y, Jacob CO (1991) Regulation of MHC class II antigen expression: opposing effects of TNF-α on IFN-γ induced HLA-DR and Ia expression depends on the maturation and differentiation state of the cell. J Immunol 146:899 Google Scholar
Wolf RE, Brelsford WG (1988) Soluble interleukin-2 receptors in systemic lupus erythematosus. Arthritis Rheum 31:729 Google Scholar
Wong GHW, Goeddel DV (1986) Tumor necrosis factor-α and -β inhibit virus replication and synergize with interferons. Nature 323:819 Google Scholar
Yasukawa K, Saito T, Fukunaga T, et al (1990) Purification and characterization of soluble human IL-6 receptor expressed in CHO cells. J Biochem 108:673 Google Scholar
Yssel H, De Waal-Malefyt R, Roncarolo MG, Abrams JS, Lahesmaa R, Spits H, de Vries JE (1992) IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells. J Immunol 149:2378 Google Scholar