Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors (original) (raw)
References
Aaronson, SA (1991) Growth factors and cancer. Science 254:1146–1153 Google Scholar
Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucheo M (1988) Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53:549–554 CASPubMed Google Scholar
Andrén-Sandberg A (1990) Treatment with an LHRH analogue in patients with advanced pancreatic cancer. Acta Chir Scand 156:549–551 Google Scholar
Barton CM, Hall PA, Hughes CM, Gullick WJ, Lemoine NR (1991) Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer. J Pathol 163:111–116 Google Scholar
Barton CM, Staddon SL, Hughes CM, Hall PA, O'Sullivan C, Klöppel G, Theis B, Russel RCG, Neoptolemos J, Williamson RCN, Lane DP, Lemoine NR (1991) Abnormalities of the p53 tumor suppressor gene in human pancreatic cancer. Br J Cancer 64:1076–1082 CASPubMed Google Scholar
Bellosta P, Talarico D, Rogers D, Basilico C (1993) Cleavage of K-FGF produces a tuncated molecule with increased biological activity and receptor binding affinity. J Cell Biol 121:705–713 Google Scholar
Bouche G, Gas N, Prats H, Baldin V, Tauber JP, Teissie J, Amalrie F (1987) Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing G0-G1 transition. Proc Natl Acad Sci USA 84:6770–6774 Google Scholar
Büchler M, Friess H, Schultheiss KH, Gebhardt C, Kübel R, Muhrer KH, Winkelmann M, Wagener T, Klapdor R, Kaul M, Müller G, Schulz G, Beger HG (1991) A randomized controlled trial of adjuvant immuno-therapy (murine monoclonal antibody 494/32) in resectable pancreatic cancer. Cancer 68:1507–1512 PubMed Google Scholar
Büchler M, Ebert M, Beger HG (1993) Grenzen chirurgischen Handelns beim Pankreaskarzinom. Langenbecks Arch Chir Suppl:460–464
Bugler B, Amalrie F, Prats H (1991) Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor. Mol Cell Biol 11:573–577 Google Scholar
Burgess WH, Maciag T (1989) The heparin-binding (fibroblast) growth factor family of proteins. Annu Rev Biochem 58:575–606 Google Scholar
Caldas C, Hahn SA, Hurban RH, Redston MS, Yeo CJ, Kern SE (1994) Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia. Cancer Res 54:3568–3573 Google Scholar
Caron de Fromentel C, Soussi T (1992) TP 53 Tumour suppressor gene: a model for investigating human mutagenesis. Genes Chromosom Cancer 4:1–15 Google Scholar
Casey G, Yamanaka Y, Friess H, Kobrin MS, Lopez ME, Büchler M, Beger HG, Korc M (1993) p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis. Cancer Lett 69:151–160 Google Scholar
Chandrasekar B, Korc M (1992) Binding and biological actions of acidic and basic fibroblast growth factors in isolated rat pancreatic acini. Gastroenterology 102:A725 (abstract) Google Scholar
Chen P-L, Chen Y, Brookstein R, Lee W-H (1990) Genetic mechanisms of tumor suppression by the human p53 gene. Science 250:1576–1580 Google Scholar
Ciccodicola A, Dono R, Obici S, Simeone A, Zollo M, Persico MG (1989) Molecular characterization of a gene of the ‘EGF family’ expressed in undifferentiated human NTERA2 teratocarcinoma cells. EMBO J 8:1987–1991 Google Scholar
Couffinhal T, Duplaa C, Moreau C, Lamaziere J-M D, Bonnet J (1994) Regulation of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 in human vascular smooth muscle cells. Circ Res 74:225–234 Google Scholar
Coussens L, Yank-Feng TL, Liao YC, Chen E, Gray A, McGrath J, Seeburg PH, Libermann TA, Schlessinger J, Francke U (1985) Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science 230:1132–1139 CASPubMed Google Scholar
Cullinan SA, Moertel CG, Fleming TR, for the North Central Cancer Treatment Group (1985) A comparison of three chemotherapeutic regimens in the treatment of advanced pancreatic and gastric carcinoma. JAMA 253:2061 ArticleCASPubMed Google Scholar
Damon DH, Lobb RR, D'Amore PA, Wagner JA (1989) Heparin potentiates the action of acidic fibroblast growth factor by prolonging its biological half-life. J Cell Physiol 138:221–226 Google Scholar
Derynck R (1988) Transforming growth factor-alpha. Cell 54:593–595 Google Scholar
Di Fiore PP, Pierce JH, Kraus MH, Segatto O, King CR, Aaronson, SA (1987) erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science 237:178–182 Google Scholar
Diller L, Kassel J, Nelson CE, Gryka MA, Litwak G, Gebhardt M, et al (1990) p53 functions as a cell cycle control protein in osteosarcoms. Mol Cell Biol 10:5772–5781 Google Scholar
Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759–767 Google Scholar
Folkman J, Klagsbrun M (1987) Angiogenic factors. Science 235:442–447 Google Scholar
Friess H, Büchler M, Schulz G, Beger HG (1989) Therapie des Pankreaskarzinoms mit dem monoklonalen Antikörper BW 494/32: erste klinische Ergebnisse. Immun Infekt: 17:24–26 Google Scholar
Friess H, Büchler M, Krüger M, Beger HG (1992) Treatment of duct carcinoma of the pancreas with the LH-RH analogue buserelin. Pancreas 7:516–521 CASPubMed Google Scholar
Friess H, Kobrin MS, Korc M (1992) Acidic and basic fibroblast growth factors and their receptors are expressed in the human pancreas (abstract). Pancreas 7:737 Google Scholar
Friess H, Büchler M, Beglinger C, Krüger M, Beger HG (1993) Low-dose octreotide treatment is not effective in patients with advanced pancreatic cancer. Pancreas 8:540–544 CASPubMed Google Scholar
Friess H, Yamanaka Y, Büchler M, Beger HG, Kobrin MS, Baldwin RL, Korc M (1993) Enhanced expression of the type II transforming growth factor-beta receptor in human pancreatic cancer cells without alteration of type III receptor expression. Cancer Res 53:2704–2707 CASPubMed Google Scholar
Friess H, Yamanaka Y, Büchler M, Ebert M, Beger HG, Gold LI, Korc M (1993) Enhanced expression of transforming growth factor-beta isoforms in pancreatic cancer correlates with decreased survival. Gastroenterology 105:1846–1856 CASPubMed Google Scholar
Friess H, Yamanaha Y, Korc M, Büchler MW (1994) Overexpression of c-_erbB_-3 in human pancreatic cancer: correlation with tumor aggressiveness (abstract). Digestion 55:299 Google Scholar
Fu Y-M, Spirito P, Yu Z-X, Biro S, Sasse J, Lei J, Ferrans VJ, Epstein SE, Casscells W (1991) Acidic fibroblast growth factor in the developing rat embryo. J Cell Biol 114:1261–1273 Google Scholar
Givol D, Yayon A (1992) Complexity of FGF receptors: genetic basis for structural diversity and functional specificity. FASEB J 6:3362–3369 Google Scholar
Glinsmann-Gibson BJ, Korc M (1991) Regulation of transforming growth factor-a mRNA expression in T3M4 human pancreatic carcinoma cells. Pancreas 6:142–149 Google Scholar
Gomm JJ, Smith J, Ryall GK, Baillie R, Turnbull L, Coombes RC (1991) Localization of basic fibroblast growth factor and transforming growth factor b1 in the human mammary gland. Cancer Res 51:4685–4692 Google Scholar
Gospoderowicz D, Neufeld G, Schweigerer L (1986) Molecular and biological characterization of fibroblast growth factor, an angiogenic factor which also controls the proliferation and differentiation of mesoderm and neuroectoderm derived cells. Cell Diff 19:1–17 Google Scholar
Gospodarowicz D, Ferrara N, Schweigerer L, Neufeld G (1987) Structural characterization and biological functions of fibroblast growth factor. Endocrine Rev 8:95–114 Google Scholar
Grünewald K, Lyons J, Fröhlich A, Feichtinger H, Weger RA, Schwab G, Janssen JWG, Bartram CR (1989) High frequency of Ki-ras codon 12 mutations in pancreatic adenocarcinomas. Int J Cancer 43:1037–1041 Google Scholar
Gudjonsson B (1987) Cancer of the pancreas. 50 years of surgery. Cancer 60:2284–2303 CASPubMed Google Scholar
Haines DS, Landers JE, Engle LJ, George DL (1994) Physical and fucntional interaction between wild-type p53 and mdm2 proteins. Mol Cell Biol 14:1171–1178 Google Scholar
Hall PA, Huges CM, Staddon SL, Richman PI, Gullick WJ, Lemoine NR (1990) The c-_erbB_-2 protooncogene in human pancreatic cancer. J Pathol 161:1995–2000 Google Scholar
Hebda PA (1988) Stimulatory effects of transforming growth factor-beta and epidermal growth factor on epidermal cell outgrowth from porcine skin explant cultures. J Invest Dermatol 91:440–445 Google Scholar
Higashiyama S, Abraham JA, Miller J, Fiddes JC, Klagsbrun M (1991) A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 251:936–939 Google Scholar
Hitoshi K, Kokichi S, Noriko F, Akiko K, Haruhiko N, Kazuaki S, et al (1994) Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma. Cancer 73:1589–1594 Google Scholar
Höhne MW, Halatsch M-E, Kahl GF, Weinel RJ (1992) Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma. Cancer Res 52:2616–2619 Google Scholar
Hollenstein M, Sidransky D, Vogelstein B, Harris CC (1991) p53 mutations in human cancers. Science 253:49–53 CASPubMed Google Scholar
Holmes WE, Sliwkowski MX, Akita RW (1992) Identification of heregulin, a specific activator of p185erbB2. Science 256:1205–1210 Google Scholar
Horii A, Nakatsuru S, Miyoshi Y, Ichii S, Nagase H, Ando H, Yanagisawa A, Tsuchiya E, Kato Y, Nakamura Y (1992) Frequent somatic mutations of the APC gene in human pancreatic cancer. Cancer Res 52:6696–6698 Google Scholar
Hudziak RM, Schlessinger J, Ullrich A (1987) Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells. Proc Natl Acad Sci USA 84:7159–7163 Google Scholar
Iggo R, Gatter K, Bartek J, Lane DP, Harris AL (1990) Increased expression of mutant forms of p53 oncogene in primary lung cancer. Lancet 335:675–677 Google Scholar
Kalthoff H, Schmiegel W, Roeder C, Kasche D, Schmidt A, Lauer G, et al (1993) p53 and K-ras alterations in pancreatic epithelial cell lesions. Oncogene 8:289–298 CASPubMed Google Scholar
Kazuhiro I, Ishkura H, Kaji M, Sugiura H, Ishizu A, Takahashi C, et al (1993) Importance of E-selectin (ELAM-1) and Sialyl Lewis in the adhesion of pancreatic carcinoma cells to activated endothelium. Int J Cancer 54:972–977 Google Scholar
Klagsbrun M (1989) The fibroblast growth factor family: structural and biological properties. Progr Growth Factor Res 1:207–235 Google Scholar
Kobrin MS, Yamanaka Y, Friess H, Lopez ME, Korc M (1993) Aberrant expression of the type I fibroblast growth factor receptor in human pancreatic adenocarcinomas. Cancer Res 53:4741–4744 Google Scholar
Korc M, Finman JE (1989) Attenuated processing of epidermal growth factor in the face of marked degradation of transforming growth factor alpha. J Biol Chem 264:14990–14999 Google Scholar
Korc M, Magun B (1985) Recycling of epidermal growth factor in a human pancreatic carcinoma cell line. Proc Natl Acad Sci USA 82:6172–6175 Google Scholar
Korc M, Meltzer P, Trent J (1986) Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer. Proc Natl Acad Sci USA 83:5141–5144 Google Scholar
Korc M, Chandrasekar B, Yamanaka Y, Friess H, Büchler M, Beger HG (1992) Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increase in the levels of epidermal growth factor and transforming growth factor alpha. J Clin Invest 90:1352–1360 Google Scholar
Kraus MH, Issing W, Miki T, Popescu NC, Aaronson SA (1989) Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci USA 86:9193–9197 Google Scholar
Lane DP, Bechimol S (1990) p53: oncogene or anti-oncogene? Gene Dev 4:1–8 Google Scholar
Laurent-Puig P, Lubin R, Semhoun-Ducloux S, Pelletier G, Fourre C, Ducreux M, et al (1995) Antibodies against p53 protein in serum of patients with benign or malignant pancreatic and biliary diseases. Gut 36:455–458 Google Scholar
Lemoine NR (1990) ras oncogenes in human cancers. In: Sluyser M (ed) Molecular biology of cancer genes. Horwood, Chichester, pp 82–118 Google Scholar
Lemoine NR, Hall PA (1990) Growth factors and oncogenes in pancreatic cancer. Baillieres Clin Gastroenterol 4:815–832 Google Scholar
Lemoine NR, Lobresco M, Leung H, Barton C, Hughes CM, Prigent SA, Gullick WJ, Klöppel G (1992) The erbB-3 gene in human pancreatic cancer. J Pathol 168:269–273 Google Scholar
Lemoine NR, Jain S, Hughes CM, Staddon SL, Maillet B, Hall PA, Kloppel G (1992) Ki-ras oncogene activation in preinvasive pancreatic cancer. Gastroenterology 102:230–236 Google Scholar
Levine A (1992) The p53 tumour suppressor gene and product. Cancer Surv 12:59–79 Google Scholar
Levine AJ, Momand J, Finaly CA (1991) The p53 tumour suppressor gene. Nature 351:453–456 Google Scholar
Levine AJ, Perry ME, Chang A, Silver A, Dittmer D, Wu M, Welsh D (1994) The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis. Br J Cancer 69:409–416 Google Scholar
Li S, Shipley GD (1991) Expression of multiple species of basic fibroblast growth factor mRNA and protein in normal and tumor-derived mammary epithelial cells in culture. Cell Growth Diff 2:195–202 Google Scholar
Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield MD, Ullrich A, Schlessinger J (1985) Amplification, enhanced expression, and possible rearrangement of the EGF receptor gene in primary human brain tumors of glial origin. Nature 313:144–147 CASPubMed Google Scholar
Lin HY, Wang X-F, Ng-Eaton E, Weinberg RA, Lodish HP (1992) Expression cloning of the TGF-ß type II receptor, a functional transmembrane serine/threonine kinase. Cell 68:775–785 Google Scholar
Lopez-Casillas F, Cheifetz S, Doody J, Andres JL, Lane WS, Massague J (1991) Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-B receptor system. Cell 67:785–795 Google Scholar
Madri JA, Pratt BM, Tucker AM (1988) Phenotypic modulation of endothelial cells by transforming growth factor-b depends upon the composition and organization of the extracellular matrix. J Cell Biol 106:1375–1384 Google Scholar
Marchionni MA, Goodearl ADJ, Chen MS (1993) Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature 362:312–318 Google Scholar
Mariyama M, Kishi K, Nakamura K, Oata H, Nishimura S (1989) Frequency and types of point mutation at the 12th codon of the c-Ki-ras gene found in pancreatic cancers in Japanese patients. Jpn J Cancer Res 80:622–266 Google Scholar
Massague J (1990) The transforming growth factor-beta family. Annu Rev Cell Biol 6:597–641 CASPubMed Google Scholar
Massague J, Cheifetz S, Laiho M, Ralph DA, Weiss FMB, Zentella A (1992) Transforming growth factor beta. Cancer Surv 12:81–103 Google Scholar
Moertel CG, Childs DS, Reitemeier RJ, Colby MY, Holbrook M (1969) Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet II:865–900 Google Scholar
Moertel, CG, Frytak, S, Hahn, R G. (1981) Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil: the Gastrointestinal Tumor Study Group. Cancer 48:1705 Google Scholar
National Cancer Institute (1991) Annual cancer statistics review 1973–1988. NIH publication no 91–2789, Department of Health and Human Services, Bethesda Google Scholar
Neal DE, Marsh C, Bennett MK, Abel PD, Hall RR, Sainsbury JR, Harris AL (1985) Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumours. Lancet 1:366–368 Google Scholar
Neoptolemos JP (ed) (1990) Cancer of the pancreas. Baillieres Clin Gastroenterol, London, 4:4
Nigro JM, Baker SF, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S, Devilee P et al. (1989) Mutatines in the p53 gene occur in diverse human tumour types. Nature 342:705–708 Google Scholar
Peles E, Ben-Levy R, Tzahar E, Liu N, Wen D, Yarden Y (1993) Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/Her-2 suggests complex ligand receptor relationships. EMBO J 12:961–971 Google Scholar
Pellegata NS, Sessa F, Renault B, Bonato M, Leone BE, Solcia E, Ranzani GN (1994) K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions. Cancer Research 54: 1556–1560 Google Scholar
Plowman GD, Green JM, McDonald VL, Neubauer MG, Disteche CM, Todaro GJ, Shoyab M (1981) The ampiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. Mol Cell Biol 10:1969–1981 Google Scholar
Plowman GD, Culouscou JM, Whitney GS, Green JM, Carlton GW, Foy L, Neubauer MG, Shoyab M (1993) Ligand specific activation of HER4/pl80erbB4, a fourth member of the epidermal growth factor receptor family. Proc Natl Acad Sci USA 90:1746–1750 Google Scholar
Prigent SA, Lemoine NR (1992) The type 1 (EGFR-related) family of growth factor receptors and their ligands. Progress in Growth Factor Research 4:1–24 Google Scholar
Roberts AB, Sportn MG, Assoian RK, Smith JM, Roche NS (1986) Transforming growth factor type-b: rapid induction of fibrosis and angiogenesis vivo and stimulation of collagen formation vitro. Proc Natl Acad Sci USA 83:4167–4171 Google Scholar
Ruggeri B, Zhang SY, Caamano J, Dirado M, Flynn SD, Kleinszanto AJP (1992) Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumour suppressor genes. Oncogene 7:1503–1511 Google Scholar
Sainsbury JR, Farndon JR, Sherbet GV, Harris AL (1985) Epidermal-growth-factor receptors and oestrogen receptors in human breast cancer. Lancet 1:364–366 Google Scholar
Sawada T, Ho JJL, Chung Y-S, Sowa M, Kim Ys (1994) Eselectin binding by pancreatic tumor cells is inhibited by cancer sera. Int J Cancer 57:901–907 Google Scholar
Scarpa A, Capelli P, Mukai K, Zamboni G, Oda T, Iacono C, et al (1993) Pancreatic adenocarcinomas frequently show p53 gene mutations. Am J Pathol 142:1534–1543 Google Scholar
Schaeffer B, Zunlo J, Longnecker DS (1990) Activation of c-K-ras is not detectable in adenomas or adenocarcinomas arising in the rat pancreas. Mol Carcinogen 3:165–170 Google Scholar
Schlessinger J, Ullrich A (1992) Growth factor signaling by receptor tyrosine kinases. Neuron 9:383–391 Google Scholar
Schwaeble W, Kerlin M, Meyer zum Büschenfelde M, Dippold W (1993) De novo expression of intercellular adhesion molecule-1 in pancreas cancer. Int J Cancer 53:328–333 Google Scholar
Shimoyama Y, Gotoh M, Ino Y, Sakamoto M, Kato K, Hirohashi S (1991) Characterization of high-molecular-mass forms of basic fibroblast growth factor produced by hepatocellular carcinoma cells: possible involvement of basic fibroblast growth factor in hepatocarcinogenesis. Jpn J Cancer Res 82:1263–1270 Google Scholar
Silverberg, E, Lubera, J A (1989) Cancer statistics. Cancer J Clin 3:3–39 Google Scholar
Simon B, Weinel R, Höhne M, Watz J, Schmidt J, Kortner G, Arnold R (1994) Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma. Gastroenterology 106:1645–1651 Google Scholar
Smit VTHBM, Boot AJM, Smits AMM, Fleuren GJ, Cornelisse CJ, Bos JL (1988) KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. Nucleic Acid Res 16:7773–7782 Google Scholar
Smith JJ, Derynck R, Korc M (1987) Production of transforming growth factor in human pancreatic cancer cells: evidence for a superagonist autocrine cycle. Proc Natl Acad Sci USA 84:7567–7570 Google Scholar
Sporn MB, Roberts AB (1992) Transforming growth factor-b: recent progress and new challenges. J Cell Biol 119:1017–1021 ArticleCASPubMed Google Scholar
Springer TA, Dustin ML, Kishimoto TK, Marlin SD (1987) The lymphocyte-function-associated LFA-1, CD2 and LFA-3 molecules: cell-adhesion receptores of the immune system. Am Rev Immun 5:223–252 Google Scholar
Steiner MS, Barrack ER (1992) Transforming growth factor-b1, overproduction in prostate cancer: effects on growth vivo and vitro. Mol Endocrinol 6:15–25 Google Scholar
Tada M, Omata M, Kawai S, Saisho H, Ohto M, Saiki RK, Sninsky JJ (1993) Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma. Cancer Res 53:2472–2474 Google Scholar
Takahasi K, Suzuki K, Ono T (1990) Loss of growth inhibitory activity of TGF-ß toward normal human mammary epithelial cells grown within collagen gel matrix. Biochem Biophys Res Commun 173:1239–1247 Google Scholar
Ullrich A, Schlessinger J (1990) Signal transduction by receptors with tyrosine kinase activity. Cell 61:203–212 CASPubMed Google Scholar
Vogelstein B, Kinzler KW (1992) p53 function and dysfunction. Cell 70:523–526 Google Scholar
Vogelstein B, Kinzler KW (1993) The multistep nature of cancer. Trends Genet 9:138–141 Google Scholar
Warshaw AL, Fernandes-Del Castillo, C (1992) Pancreatic carcinoma. N Engl J Med 326:455–465 CASPubMed Google Scholar
Watanabe H, Sawabu N, Ohta H, Satomura Y, Yamakawa O, Motoo Y, et al (1993) Identification of K-ras oncogene mutaions in the pure pancreatic juice of patients with ductal pancreatic cancers. Jpn J Cancer Res 84:961–965 Google Scholar
Wrana JL, Attisano L, Carcamo J, Zentella A, Doody J, Laiho M, Wang X-F, Massague J (1992) TGF-ß signals through a heteromeric protein kinase receptor complex. Cell 71:1003–1014 Google Scholar
Yamanaka Y, Friess H, Büchler M, Beger HG, Gold LI, Korc M (1993) Synthesis and expression of transforming growth factor-beta 1, beta 2 and beta 3 in the endocrine and exocrine pancreas. Diabetes 42:746–756 Google Scholar
Yamanaka Y, Friess H, Büchler M, Beger HG, Uchida E, Onda M, Kobrin MS Korc M (1993) Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage. Cancer Res 53:5289–5296 Google Scholar
Yamanaka Y, Friess H, Kobrin MS, Büchler M, Beger HG, Korc M (1993) Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Res 13:565–570 CASPubMed Google Scholar
Yamanaka Y, Friess H, Kobrin MS, Büchler M, Kunz J, Beger HG, Korc M (1993) Overexpression of HER2/neu oncogene in human pancreatic cancer. Hum Pathol 24:1127–1134 Google Scholar
Yokoyama M, Yamanaka Y, Friess H, Büchler M, Korc M (1994) p53 expression in human pancreatic cancer correlates with enhanced biological aggressiveness. Anticancer Res 14:2477–284 Google Scholar