Canadian Mennonites and individuals residing in the Friesland region of the Netherlands share the same molecular basis of 17α-hydroxylase deficiency (original) (raw)

Summary

A common mutation within the CYP17 gene that causes 17α-hydroxylase deficiency, a form of congenital adrenal hyperplasia, has been found by direct sequencing of polymerase chain reaction (PCR) fragments of genomic DNA from six families residing in the Friesland region of the Netherlands. The mutation is a 4-base duplication within exon 8 of the CYP17 gene, which alters the reading frame encoding the C-terminal 26 amino acids of cytochrome P45017α. This mutation has previously been found in two Canadian patients who are members of ostensibly unrelated Mennonite families. The Mennonite Churches derive their name from Menno Simons, an early leader of the sect in Friesland. Presumably this 4-base duplication appeared within the Friesian population prior to emigration of the Mennonites from the Netherlands.

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Authors and Affiliations

1. Departments of Biochemistry and Obstetrics and Gynecology and The Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas, Southwestern Medical Center, 75235, Dallas, TX, USA
   Tsuneo Imai, Toshihiko Yanase, Michael R. Waterman & Evan R. Simpson
2. Isotope Laboratory, Academic Hospital, Groningen, The Netherlands
   John J. Pratt

Authors

1. Tsuneo Imai
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2. Toshihiko Yanase
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3. Michael R. Waterman
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4. Evan R. Simpson
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5. John J. Pratt
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Imai, T., Yanase, T., Waterman, M.R. et al. Canadian Mennonites and individuals residing in the Friesland region of the Netherlands share the same molecular basis of 17α-hydroxylase deficiency.Hum Genet 89, 95–96 (1992). https://doi.org/10.1007/BF00207050

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• Received: 08 August 1991
• Revised: 08 October 1991
• Issue Date: April 1992
• DOI: https://doi.org/10.1007/BF00207050

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