Excitation of cutaneous afferent nerve endings in vitro by a combination of inflammatory mediators and conditioning effect of substance P (original) (raw)

• Andrews PV, Helme RD, Thomas KL (1989) NK-1 receptor mediation of neurogenic plasma extravasation in rat skin. Br J Pharmacol 97: 1232–1238
  Google Scholar
• Beck PW, Handwerker HO (1974) Bradykinin and serotonin effects on various types of cutaneous nerve fibres. Pflugers Arch 347: 21–28
  Google Scholar
• Beck PW, Handwerker HO, Zimmermann M (1974) Nervous out-flow from the cat's foot during noxious radiant heat stimulation. Brain Res 67: 373–386
  Google Scholar
• Bretag A (1969) Synthetic interstitial fluid for isolated mammalian tissue. Life Sci 8: 319–329
  Google Scholar
• Brown AG, Iggo A (1967) A quantitative study of cutaneous receptors and afferent fibres in the cat and rabbit. J Physiol (Lond) 193: 707–733
  Google Scholar
• Cervero F, Sann H (1989) Mechanically evoked responses of afferent fibres innervating the guinea-pig's ureter — an in vitro study. J Physiol (Lond) 412: 245–266
  Google Scholar
• Cohen RH, Perl ER (1990) Contributions of arachidonic acid derivatives and substance P to the sensitization of cutaneous nociceptors. J Neurophysiol 64: 457–464
  Google Scholar
• Dray A, Bettaney J, Forster P, Perkins MN (1988) Bradykinin-induced stimulation of afferent fibres is mediated through protein kinase C. Neurosci Lett 91: 301–307
  Google Scholar
• Fjällbrant N, Iggo A (1961) The effect of histamine, 5-hydroxytryptamine and acetylcholine on cutaneous afferent fibres. J Physiol (Lond) 156: 578–590
  Google Scholar
• Fleischer E, Handwerker HO, Joukhadar S (1983) Unmyelinated nociceptive units in two skin areas of the rat. Brain Res 267: 81–92
  Google Scholar
• Grubb BD, Birrell GJ, McQueen DS, Iggo A (1991) The role of PGE2 in the sensitization of mechanoreceptors in normal and inflamed ankle joints of the rat. Exp Brain Res 84: 383–392
  Google Scholar
• Handwerker HO (1976a) Influences of algogenic substances and prostaglandins on the discharges of unmyelinated cutaneous nerve fibers identified as nociceptors. In: Bonica JJ, Albe-Fessard D (eds) Advances in pain research and therapy, vol 1. Raven Press, New York, pp 41–45
  Google Scholar
• Handwerker HO (1976b) Pharmacological modulation of the discharge of nociceptive C-fibres. In: Zotterman Y (ed) Sensory functions of the skin in primates. Pergamon Press, Oxford, pp 427–437
  Google Scholar
• Handwerker HO, Reeh PW (1991) Pain and inflammation. In: Bond MR, Charlton JE, Woolf CJ (eds) Proceedings of the Fifth World Congress on Pain. Elsevier Scientific, Amsterdam, pp 59–69
  Google Scholar
• Handwerker HO, Adriaensen H, Gybels J, Van Hees J (1984) Nociceptor discharges and pain sensations: results and open questions. In: Bromm B (ed) New approaches to pain measurement in man. Elsevier Scientific, Amsterdam, pp 55–65
  Google Scholar
• Handwerker HO, Anton F, Reeh PW (1987) Discharge patterns of afferent cutaneous nerve fibers from the rat's tail during prolonged noxious mechanical stimulation. Exp Brain Res 65: 493–504
  Google Scholar
• Hägermark Ö, Hökfelt T, Pernow B (1978) Flare and itch induced by substance P in human skin. J Invest Dermatol 71: 233–235
  Google Scholar
• Iggo A (1958) The electrophysiological identification of single nerve fibres, with particular reference to the slowest-conducting vagal afferent fibres in the cat. J Physiol (Lond) 142: 110–126
  Google Scholar
• Iggo A, Kornhuber HH (1977) A quantitative study of C-mechanoreceptors in hairy skin of the cat. J Physiol (Lond) 271: 549–565
  Google Scholar
• Jancso N, Jancso-Gabor A, Szolcsanyi J (1968) The role of sensory nerve endings in neurogenic inflammation induced in human skin and in the eye and paw of the rat. Br J Pharmacol 32: 32–41
  Google Scholar
• Johansson RS, Vallbo AB (1983) Tactile sensory coding in the glabrous skin of the human hand. Trends Neurosci 1: 27–32
  Google Scholar
• Keele CA, Armstrong D (1964) Substances producing pain and itch. Edward Arnold, London
  Google Scholar
• Koltzenburg M, Kress M, Reeh PW (1992) The nociceptor sensitization by bradykinin does not depend on sympathetic neurones. Neuroscience 46: 465–473
  Google Scholar
• Kress M, Koltzenburg M, Reeh PW, Handwerker HO (1991) Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers, in vivo and in vitro. J Neurophysiol (in press)
• Kumazawa T, Mizumura K (1979) Effects of synthetic substance P on unit discharges of testicular nociceptors of dogs. Brain Res 170: 553–557
  Google Scholar
• Kumazawa T, Mizumura K, Sato J (1987) Response properties of polymodal receptors studied using in vitro testis superior spermatic nerve preparations of dogs. J Neurophysiol 57: 702–711
  Google Scholar
• Kumazawa T, Mizumura K, Sato J (1988) Modulation of testicular polymodal receptor activities. Prog Brain Res 74: 325–330
  Google Scholar
• Lang E, Novak A, Reeh PW, Handwerker HO (1990) Chemosensitivity of fine afferents from rat skin in vitro. J Neurophysiol 63: 887–901.
  CAS PubMed Google Scholar
• Lembeck F (1983) Sir Thomas Lewis nocifensor system, histamine and substance-P-containing primary afferent nerves. Trends Neurosci 6: 106–108
  Google Scholar
• Lembeck F, Gamse R (1982) Substance P in peripheral nervous processes. In: Porter R, O'Connor M (eds) Substance P in the nervous system. Ciba Foundation Symposium 91. Pitman, London, pp 35–49
  Google Scholar
• Louis SM, Jamieson A, Russell NJW, Dockray GJ (1989) The role of substance P and calcitonin gene-related peptide in neurogenic plasma extravasation and vasodilatation in the rat. Neuroscience 32: 581–586
  Google Scholar
• Lynn B, Carpenter SE (1982) Primary afferent units from the hairy skin of the rat hind limb. Brain Res 238: 29–43
  Google Scholar
• Lynn B, Shakhanbeh J (1988) Properties of A delta high threshold mechanoreceptors in the rat hairy and glabrous skin and their response to heat. Neurosci Lett 85: 71–76
  Google Scholar
• Mense S (1986) Slowly conducting afferent fibres from deep tissues: neurobiological properties and central nervous actions. Prog Sensory Physiol 6: 139–219
  Google Scholar
• Mizumura K, Sato J, Kumazawa T (1987) Effects of prostaglandins and other putative chemical intermediaries on the activity of canine testicular polymodal receptors studied in vitro. Pflugers Arch 408: 565–572
  Google Scholar
• Morton CR, Hutchison WD, Duggan AW, Hendry IA (1990) Morphine and substance-P release in the spinal cord. Exp Brain Res 82: 89–96
  Google Scholar
• Payan DG (1989) Neuropeptides and inflammation: the role of substance P. Ann Rev Med 40: 341–353
  Google Scholar
• Quirion R, Dam TV (1988) Multiple neurokinin receptors: recent developments. In: Bloom FE, Hakanson R (eds) Regulatory peptides, vol 22. Elsevier Science, Amsterdam, pp 18–25
  Google Scholar
• Raja SN, Meyer RA, Campbell JN (1988) Peripheral mechanisms of somatic pain. Anesthesiology 68: 571–590
  Google Scholar
• Raja SN, Kozak SL, Manning DC, Meyer RA, Campbell JN (1990) Intradermal bradykinin induces hyperalgesia to heat stimuli in man. Pain [Suppl 5]: S130–S131
• Reeh PW (1986) Sensory receptors in mammalian skin in an in vitro preparation. Neurosci Lett 66: 141–147
  Google Scholar
• Reeh PW (1988) Sensory receptors in mammalian skin — nerve in vitro preparation. In: Hamann W, Iggo A (eds) Prog Brain Res 74:271–276
• Reeh PW, Bayer J, Kocher L, Handwerker HO (1987) Sensitization of nociceptive cutaneous nerve fibres from the rat's tail by noxious mechanical stimulation. Exp Brain Res 65: 505–512
  Google Scholar
• Schaible H-G, Jarrott B, Hope PJ, Duggan AW (1990) Release of immunoreactive substance P in the spinal cord during development of acute arthritis in the knee joint of the cat: a study with antibody microprobes. Brain Res 529: 214–223
  Google Scholar
• Schaible H-G, Schmidt RF (1988) Excitation and sensitization of fine articular afferents from cat's knee joint by prostaglandin E2. J Physiol (Lond) 403: 91–104
  Google Scholar
• Spigelman I, Puil E (1988) Excitatory responses of trigeminal neurons to substance P suggest involvement in sensory transmission. Can J Physiol Pharmacol 66: 845–848
  Google Scholar
• Steen KH, Hanisch AE, Reeh PW (1991) A dominant role of acid pH in inflammatory excitation of nociceptors in rat skin. Pflugers Arch 418 [Suppl 1]: R42
  Google Scholar
• Steen KH, Reeh PW, Anton F, Handwerker HO (1992) Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro. J Neurosci 12: 86–95.
  CAS PubMed Google Scholar
• Szolcsanyi J, Anton F, Reeh PW, Handwerker HO (1988) Selective excitation by capsaicin of mechano-heat sensitive nociceptors in rat skin. Brain Res 446: 262–268
  Google Scholar
• von Frey M (1886) Untersuchungen über die Sinnesfunktionen der menschlichen Haut. Erste Abhandlung: Druckempfindung und Schmerz. Abh Math Phys Classe Kgl Sächs Ges Wiss 23: 208–217, 239
  Google Scholar
• Wallengren J, Hakanson R (1987) Effects of substance P, neurokinin A and calcitonin gene related peptide in human skin and their involvement in sensory nerve-mediated responses. Eur J Pharmacol 143: 267–273
  Google Scholar