Behavioural, physiological, and anatomical consequences of monocular deprivation in the golden hamster (Mesocricetus auratus) (original) (raw)
Summary
The effects of long-term monocular deprivation (MD) on the visual acuity, cortical physiology and dLGN anatomy of the golden hamster were assessed in adult animals which had undergone unilateral eyelid suture at the time of natural eyelid opening. Acuity was measured in a two-alternative forced-choice task in a Y-maze, using a modified method of constant stimuli to vary the spatial frequency of a high-contrast square-wave grating which had the same mean luminance (5 cd/m2) as a uniform grey card. The acuity of the normal (non-deprived) eye of each of two early-MD hamsters was within the normal range (about 0.5 cycles per degree of visual angle), but the acuity of the deprived eyes was reduced by about 0.6 octaves at the 70%-correct criterion. A second reversal of eyelid suture and retesting through the “normal” eye demonstrated that this acuity difference was not attributable to surgical artifacts. Another hamster undergoing prolonged MD beginning in adulthood had normal acuity in both eyes, indicating a “sensitive period” in the development of the hamster's visual system. Single-unit recording from area V1 of the cortex of four early-MD hamsters revealed a shift in ocular dominance favouring the normal eye. The deprived eye's loss of excitatory influence was greater in the ipsilateral hemisphere, but even here 57% of cells were binocularly driven. Only small differences were observed in other receptive field properties. In the dLGN, cell areas in the deprived “lamina” were about 4% smaller than in the non-deprived areas after 5–7.5 months of MD, a difference which was statistically non-significant. However, this difference increased to 19.5% in one hamster in which MD lasted 17 months (p < 0.025). The relatively small MD effect observed in the hamster is interpreted as being consistent with the absence of a sensitive “detail-analysing” mechanism in the hamster's visual system.
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References
- Barlow HB (1975) Visual experience and cortical development. Nature 258: 199–204
Google Scholar - Blakemore C (1978) Maturation and modification in the developing visual system. In: Held R, Leibowitz HW, Teuber HL (eds) Handbook of sensory physiology. Springer, Berlin Heidelberg New York (vol VIII, Perception, pp 377–436)
Google Scholar - Casagrande VA, Guillery RW, Harting JK (1978) Differential effects of monocular deprivation seen in different layers of the lateral geniculate nucleus. J Comp Neurol 179: 469–486
Google Scholar - Chalupa LM, Morrow AL, Rhoades RW (1978) Behavioral consequences of visual deprivation and restriction in the golden hamster. Exp Neurol 61: 442–454
Google Scholar - Chow KL, Spear PD (1974) Morphological and functional effects of visual deprivation on the rabbit visual system. Exp Neurol 42: 429–447
Google Scholar - Crawford MLJ, Blake R, Cool SJ, Noorden GK von (1975) Physiological consequences of unilateral and bilateral eye closure in macaque monkey: some further observations. Brain Res 84: 150–154
Google Scholar - Crawford MLJ, Marc RE (1976) Light transmission of cat and monkey eyelids. Vision Res 16: 323–324
Google Scholar - Dräger UC (1975) Receptive fields of single cells and topography in mouse visual cortex. J Comp Neurol 160: 269–290
Google Scholar - Dräger UC (1978) Observations on monocular deprivation in mice. J Neurophysiol 41: 28–42
Google Scholar - Dürsteler MR, Blakemore C, Garey LJ (1977) Uptake of horseradish peroxidase by geniculo-cortical axons in the golden hamster: analysis by computer reconstruction. Exp Brain Res 29: 487–500
Google Scholar - Emerson VF (1980) Grating acuity of the golden hamster. The effects of stimulus orientation and luminance. Exp Brain Res 38: 43–52
Google Scholar - Emerson VF, Baker AG (1981) Luminance effects on the grating acuity of the mongolian gerbil. Paper presented at annual meeting of the Canadian Psychological Association, Toronto
- Fifková E, Hassler R (1969) Quantitative morphological changes in visual centers in rats after unilateral deprivation. J Comp Neurol 135: 167–178
Google Scholar - Frost DO, So K-F, Schneider GE (1979) Postnatal development of retinal projections in Syrian hamsters: a study using autoradiographic and anterograde degeneration techniques. Neuroscience 4: 1649–1677
Google Scholar - Giffin F, Mitchell DE (1978) The rate of recovery of vision after early monocular deprivation in kittens. J Physiol (Lond) 274: 511–537
Google Scholar - Guillery RW, Kaas J (1974) The effects of monocular lid suture upon the development of the lateral geniculate nucleus in squirrels (Sciureus carolinensis). J Comp Neurol 154: 433–442
Google Scholar - Headon MP, Powell TPS (1973) Cellular changes in the lateral geniculate nucleus of infant monkeys after suture of the eyelids. J Anat 116: 133–145
Google Scholar - Hendrickson A, Boles J, McLean EB (1977) Visual acuity and behavior of monocularly deprived monkeys after retinal lesions. Invest Ophthalmol Vis Sci 16: 469–473
Google Scholar - Hickey TL, Spear PD, Kratz KE (1977) Quantitative studies of cell size in the cat's dorsal lateral geniculate nucleus following visual deprivation. J Comp Neurol 172: 265–282
Google Scholar - Hubel DH (1979) The visual cortex of normal and deprived monkeys. Am Sci 67: 532–543
Google Scholar - Hubel DH, Wiesel TN (1962) Receptive fields, binocular interaction, and functional architecture in the cat's visual cortex. J Physiol (Lond) 160: 106–154
Google Scholar - Hubel DH, Wiesel TN, LeVay S (1977) Plasticity of ocular dominance columns in monkey striate cortex. Philos Trans R Soc Lond [Biol] 278: 377–409
Google Scholar - Jhaveri SR, Schneider GE (1974) Retinal projections in Syrian hamsters: normal topography and alterations after partial tectum lesions at birth. Anat Rec 178: 383
Google Scholar - Kalil R (1980) A quantitative study of the effects of monocular enucleation and deprivation on cell growth in the dorsal lateral geniculate nucleus of the cat. J Comp Neurol 189: 483–524
Google Scholar - Rhoades RW, Chalupa LM (1978) Receptive field characteristics of superior colliculus neurons and visually guided behavior in dark-reared hamsters. J Comp Neurol 177: 17–32
Google Scholar - Rothblat LA, Schwartz ML, Kasdan PM (1978) Monocular deprivation in the rat: evidence for an age-related defect in visual behavior. Brain Res 158: 456–460
Google Scholar - Schwartz ML, Rothblat LA (1980) Long-lasting behavioral and dendritic spine deficits in the monocularly deprived albino rat. Exp Neurol 68: 136–146
Google Scholar - Sherman SM, Wilson JR (1975) Behavioral and morphological evidence for binocular competition in the postnatal development of the dog's visual system. J Comp Neurol 161: 183–196
Google Scholar - Sireteanu R, Hoffmann K-P (1979) Relative frequency and visual resolution of X- and Y-cells in the LGN of normal and monocularly deprived cats: interlaminar differences. Exp Brain Res 34: 591–603
Google Scholar - So K-F, Schneider GE, Frost DO (1978) Postnatal development of retinal projections to the lateral geniculate body in Syrian hamsters. Brain Res 142: 343–352
Google Scholar - Spear PD, Tong L, Langsetmo A (1978) Striate cortex neurons of binocularly deprived kittens respond to visual stimuli through the closed eyelids. Brain Res 155: 141–146
Google Scholar - Terry RJ, Roland AL, Race J (1962) Effect of eye enucleation and eyelid closure upon the brain and associated visual structures in the mouse. I. A report on degenerative changes. J Exp Zool 150: 165–183
Google Scholar - Tiao Y-C, Blakemore C (1976) Functional organization in the visual cortex of the golden hamster. J Comp Neurol 168: 459–482
Google Scholar - Van Hof MW (1970) Interocular transfer in the rabbit. Exp Neurol 26: 103–108
Google Scholar - Van Hof MW, Russell IS (1977) Binocular vision in the rabbit. Physiol Behav 19: 121–128
Google Scholar - Van Hof MW, Van der Marck F (1976) Monocular pattern discrimination in normal and monocularly light-deprived rabbits. Physiol Behav 6: 775–781
Google Scholar - Van Sluyters RC, Stewart DL (1974a) Binocular neurons of the rabbit's visual cortex: receptive field characteristics. Exp Brain Res 19: 166–195
Google Scholar - Van Sluyters RC, Stewart DL (1974b) Binocular neurons of the rabbit's visual cortex: effects of monocular sensory deprivation. Exp Brain Res 19: 196–204
Google Scholar - Wiesel TN, Hubel DH (1963a) Effects of visual deprivation on morphology and physiology of cells in the cat's lateral geniculate body. J Neurophysiol 26: 978–993
Google Scholar - Wiesel TN, Hubel DH (1963b) Single-cell responses in striate cortex of kittens deprived of vision in one eye. J Neurophysiol 26: 1003–1017
Google Scholar - Wiesel TN, Hubel DH (1965) Comparison of the effects of unilateral and bilateral eye closure on cortical unit responses in kittens. J Neurophysiol 28: 1029–1040
Google Scholar
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Author notes
- V. F. Emerson
Present address: Department of Psychology, Queen's University, K7L 3N6, Kingston, Ontario, Canada - L. M. Chalupa
Present address: Department of Psychology, University of California, 95616, Davis, CA, USA - I. D. Thompson
Present address: University Laboratory of Physiology, South Parks Road, OX1 3PT, Oxford, England
Authors and Affiliations
- Physiological Laboratory, CB2 3EG, Cambridge, England
V. F. Emerson, L. M. Chalupa, I. D. Thompson & R. J. Talbot
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- V. F. Emerson
You can also search for this author inPubMed Google Scholar - L. M. Chalupa
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Additional information
Portions of these data have been presented to the Physiological Society and to the Association for Research in Vision and Ophthalmology, and abstracts of these proceedings have been published
Supported by a Nuffield Travelling Fellowship and later by US National Institutes of Health Fellowship F32 EY05198
Supported by the Guggenheim Foundation
Recipient of an MRC Studentship
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Emerson, V.F., Chalupa, L.M., Thompson, I.D. et al. Behavioural, physiological, and anatomical consequences of monocular deprivation in the golden hamster (Mesocricetus auratus).Exp Brain Res 45, 168–178 (1982). https://doi.org/10.1007/BF00235776
- Received: 02 March 1981
- Issue Date: January 1982
- DOI: https://doi.org/10.1007/BF00235776