The internal control of action and Parkinson's disease: a kinematic analysis of visually-guided and memory-guided prehension movements (original) (raw)
Abstract
This paper reports two experiments which examined the effects of Parkinson's disease (PD) upon the sensorimotor mechanisms used to control prehension movements. Transport and grasp kinematics for visually-guided and memory-guided prehension movements were examined in healthy control subjects and compared against those of patients with idiopathic PD. Two research questions were addressed: (1) Are patients with PD particularly susceptible to distraction by non-relevant objects? (2) Are patients with PD especially reliant on external feedback when executing goal-directed actions? The results indicated that the patient group were no more susceptible to distraction by non-relevant objects than the control group. In contrast, the patients with PD were shown to be significantly, impaired when executing memory-guided reaches. Furthermore, the deficits exhibited by the PD group on memory-guided reaches were confined solely to those markers associated with the transport component of the prehension movement. That is, while both controls and patients with PD widened their grip aperture on memory-guided trials, the magnitude of this adjustment was comparable across the two groups. The implications of these findings for theories of visuomotor processing in sufferers of PD and the control of prehension movements more generally are discussed.
Access this article
Subscribe and save
- Get 10 units per month
- Download Article/Chapter or eBook
- 1 Unit = 1 Article or 1 Chapter
- Cancel anytime Subscribe now
Buy Now
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Instant access to the full article PDF.
Similar content being viewed by others
Explore related subjects
Discover the latest articles and news from researchers in related subjects, suggested using machine learning.
References
- Benecke R, Rothwell JC, Dick JPR, Day BL, Marsden CD (1986) Performance of simultaneous movements in patients with Parkinson's disease. Brain 109:739–757
PubMed Google Scholar - Berardelli A, Dick JPR, Rothwell JC, Day BL, Marsden CD (1986) Scaling of the first agonist EMG burst during rapid wrist movements in patients with Parkinson's disease. J Neurol Neurosurg Psychiatr 49:1273–1279
CAS PubMed Google Scholar - Bloxham CA, Mindel TA, Frith CD (1984) Initiation and execution of predictable and unpredictable movements in Parkinson's disease. Brain 107:371–384
Google Scholar - Brooks VB (1986) The neural basis of motor control. University Press, New York, Oxford
Google Scholar - Brown RG, Marsden CD (1988) Internal versus external cues and the control of attention in Parkinson's disease. Brain 111:323–345
CAS PubMed Google Scholar - Castiello U, Bennett KMB, Mucignat C (1993) The reach to grasp of blind subjects. Exp Brain Res 96:152–162
Google Scholar - Crawford TJ, Henderson L, Kennard C (1989) Abnormalities of non-visually-guided eye movements in Parkinson's disease. Brain 112:1573–1586
Google Scholar - Funahashi S, Bruce CJ, Goldman-Rakic PS (1986) Perimetry of spatial memory representation in primate prefrontal cortex: evidence for a mnemonic hemianopia. Soc Neurosci Abstr 12:554
Google Scholar - Funahashi S, Bruce CJ, Goldman-Rakic PS (1989) Mnemonic coding of visual space in the primate dorsolateral prefrontal cortex. J Neurophysiol 61:331–349
Google Scholar - Funahashi S, Bruce CJ, Goldman-Rakic PS (1990) Visuospatial coding in primate prefrontal neurons revealed by oculomotor paradigms. J Neurophysiol 63(4):814–831
CAS PubMed Google Scholar - Gentilucci M, Fogassi L, Luppino G, Matelli M, Camarda R, Rizzolatti G (1988) Functional organization of inferior area 6 in the macaque monkey. I. Somatotopy and the control of proximal movements. Exp Brain Res 71:475–490
PubMed Google Scholar - Goldman-Rakic PS (1987) Circuitry of primate prefrontal cortex and regulation of behavior by representational memory. In: Plum F, Mountcastle V (eds) Higher functions of the brain. (Handbook of physiology, sect 1, The nervous system, vol V).American Physiological Society, Bethesda
Google Scholar - Goldman-Rakic PS (1988) Topography of cognition: parallel distributed networks in primate association cortex. Annu Rev Neurosci 11:137–156
Google Scholar - Goldman-Rakic PS (1992) The prefrontal cortex and internally generated motor acts. Curr Opin Neurobiol 2:830–835
Google Scholar - Goodale MA (1993) Visual pathways supporting perception and action in the primate cerebral cortex. Curr Opin Neurobiol 3:578–585
Google Scholar - Goodale MA, Milner AD (1992) Separate visual pathways for perception and action. Trends Neurosci 15:20–25
Article CAS PubMed Google Scholar - Goodale MA, Jakobson LS, Keillor JM (1994) Differences in the visual control of pantomimed and natural grasping movements. Neuropsychologia
- Hallett M (1985) Quantitative assessment of motor deficiency in Parkinson's disease: ballistic movements. In: Delwaide PJ, Agnoli A (eds) Clinical neurophysiology in parkinsonism. Elsevier, Amsterdam
Google Scholar - Hallett M, Khosbin S (1980) A physiological mechanism of bradykinesia. Brain 15:465–480
CAS PubMed Google Scholar - Jackson S, Houghton G (1994) Sensorimotor selection and the basal ganglia: a neural-network model. In: Houk JC, Davis J (eds) Models of information processing in the basal ganglia. MIT Press, Cambridge, Mass
Google Scholar - Jackson SR, Marrocco R, Posner MI (1994) Networks of anatomical areas controlling visuospatial attention. Neural Networks 7 (6/7):925–944
MathSciNet Google Scholar - Jackson SR, Jackson GM, Rosicky J (1995) Are non-relevant objects represented in working memory? The effect of non-target objects on reaching and grasping kinematics. Exp Brain Res 102:519–530
Google Scholar - Jakobson L, Goodale MA (1991) Factors affecting higher-order movement planning: a kinematic analysis of human prehension. Exp Brain Res 86:199–208
CAS PubMed Google Scholar - Jeannerod M (1984) The timing of natural prehension movements. J Mot Behav 16:235–254
CAS PubMed Google Scholar - Jeannerod M (1988) The neural and behavioural organization of goal-directed movements. Oxford University Press, Oxford
Google Scholar - Lueck CJ, Crawford TJ, Henderson L, Van Gisbergen JAM, Duysens J, Kennard C (1992) Saccadic eye movements in Parkinson's disease. II. Remembered saccades — towards a unified hypothesis? Q J Exp Psychol 45A(2):211–233
Google Scholar - Rizzolatti G, Gentilucci M (1988) Motor and visual-motor functions of the premotor cortex. In: Rakic P, Singer W (eds) Neurobiology of neocortex. Wiley, New York
Google Scholar - Rizzolatti G, Camarda R, Fogassi L, Gentilucci M, Luppino G, Matelli M (1988) Functional organization of inferior area 6 in the macaque monkey. II. Area F5 and the control of distal movements. Exp Brain Res 71:491–507
CAS PubMed Google Scholar - Stelmach GE (1991) Basal ganglia impairment and force control. In: Requin J, Stelmach GE (eds) Tutorials in motor neuroscience. Kluwer Academic, Dordrecht
Google Scholar - Teasdale N, Phillips J, Stelmach GE (1990) Temporal movement control in patients with Parkinson's disease. J Neurol Neurosurg Psychiatr 53:862–868
Google Scholar - Wing AM, Turton A, Fraser C (1986) Grasp size and accuracy of approach in reaching. J Mot Behav 18:245–260
CAS PubMed Google Scholar
Author information
Authors and Affiliations
- Clinical Neuroscience Unit, Charing Cross and Westminster Medical School, Charing Cross Hospital, W6 8RF, London, UK
J. Harrison, L. Henderson & C. Kennard - Human Movement Laboratory, School of Psychology, University of Wales, LL57 2DG, Bangor, Gwynedd, UK
S. R. Jackson & G. M. Jackson
Authors
- S. R. Jackson
- G. M. Jackson
- J. Harrison
- L. Henderson
- C. Kennard
Rights and permissions
About this article
Cite this article
Jackson, S.R., Jackson, G.M., Harrison, J. et al. The internal control of action and Parkinson's disease: a kinematic analysis of visually-guided and memory-guided prehension movements.Exp Brain Res 105, 147–162 (1995). https://doi.org/10.1007/BF00242190
- Received: 17 November 1994
- Accepted: 09 March 1995
- Issue Date: July 1995
- DOI: https://doi.org/10.1007/BF00242190