Projections from inferior temporal cortex to prefrontal cortex via the uncinate fascicle in rhesus monkeys (original) (raw)
Summary
In five rhesus monkeys (Macaca, mulatta) we used anterograde and retrograde tracing techniques to investigate the projection from the inferior temporal cortex (area TE) to the prefrontal cortex as well as the course of the projecting fibers. The results showed that TE projects to both the inferior convexity and orbital surface of prefrontal cortex and that these projections course almost exclusively via the uncinate fascicle. Transection of the uncinate fascicle deprives the prefrontal cortex of virtually all input from TE, but leaves intact inputs from prestriate and parietal visual areas as well as the amygdala. Such transection also leaves intact many projections from TE to targets other than the prefrontal cortex, including the amygdala, ventral putamen, tail of the caudate nucleus, and pulvinar.
Access this article
Subscribe and save
- Get 10 units per month
- Download Article/Chapter or eBook
- 1 Unit = 1 Article or 1 Chapter
- Cancel anytime Subscribe now
Buy Now
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Instant access to the full article PDF.
Similar content being viewed by others
References
- Amaral DC, Price JL (1984) Amygdalo-cortical projections in the monkey (Macaca fascicularis). J Comp Neurol 230:465–496
Google Scholar - Barbas H, Mesulam M-M (1981) Organization of afferent input to subdivisions of area 8 in the rhesus monkey. J Comp Neurol 200:407–431
Google Scholar - Bonin G von, Bailey P (1947) The neocortex of Macaca mulatta. The University of Illinois Press, Urbana
Google Scholar - Boussaoud D, Ungerleider LG, Desimone R (1987) The cortical pathways for motion analysis: connections of visual areas MST and FST in macaques. Soc Neurosci Abstr 13:1625
Google Scholar - Bruce CJ, Goldberg ME (1985) Primate frontal eye fields. I. Single neurons discharging before saccades. J Neurophysiol 53:603–635
Google Scholar - Bruce CJ, Desimone R, Gross CG (1981) Visual properties of neurons in a polysensory area in superior temporal sulcus of the macaque. J Neurophysiol 46:369–384
Google Scholar - Chavis DA, Pandya DN (1976) Further observation on corticofrontal connections in the rhesus monkey. Brain Res 117:369–386
Google Scholar - Clemente CD (1985) Gray's Anatomy of the human body (30th American edition). Lea and Febiger, Philadelphia
Google Scholar - Crosby EC, Humphrey T (1941) Studies of the vertebrate telencephalon. II. The nuclear pattern of the anterior olfactory nuclei, tuberculum olfactorium, and the amygdaloid complex in adult man. J Comp Neurol 74:309–352
Google Scholar - Dean P (1982) Visual behavior of monkeys with inferotemporal lesions. In: Ingle DJ, Goodale MA, Mansfield RJW (eds). Analysis of visual behavior. MIT Press, Cambridge, pp 587–628
Google Scholar - Desimone R, Gross CG (1979) Visual areas in the temporal cortex of macaques. Brain Res 178:363–380
Google Scholar - Gaffan D, Harrison S (1987) Amygdalectomy and disconnection in visual learning for auditory secondary reinforcement by monkeys. J Neurosci 7:2285–2292
Google Scholar - Gaffan D, Harrison S (1988) Inferotemporal-frontal disconnection and fornix transection in visuomotor conditional learning by monkeys. Behav Brain Res 31:149–163
Google Scholar - Gaffan D, Harrison S (1989) A comparison of the effects of fornix transection and sulcus principalis ablation upon spatial learning by monkeys. Behav Brain Res 31:207–220
Google Scholar - Gaffan D, Harrison S, Gaffan EA (1986) Visual identification following inferotemporal ablation in the monkey. Q J Exp Psychol 38B:5–30
Google Scholar - Gaffan EA, Harrison S, Gaffan D (1986) Single and concurrent discrimination learning by monkeys after lesions of inferotemporal cortex. Q J Exp Psychol 38B:31–51
Google Scholar - Gaffan EA, Gaffan D, Harrison S (1988) Disconnection of the amygdala from visual association cortex impairs visual reward-association learning in monkeys. J Neurosci 8: 3144–3150
Google Scholar - Gross CG (1973) Inferotemporal cortex and vision. In: Stellar E, Sprague JM (eds) Progress in physiological psychology, Vol 5. Academic Press, New York, pp 77–123
Google Scholar - Horel JA (1978) The neuroanatomy of amnesia: a critique of the hippocampal memory hypothesis. Brain 101: 403–445
Google Scholar - Jacobson S, Trojanowski JQ (1977) Prefrontal granular cortex of the rhesus monkey. I. Intrahemispheric cortical afferents. Brain Res 132:209–233
Google Scholar - Jones EG, Powell TPS (1970) An anatomical study of converging pathways within the cerebral cortex of the monkey. Brain 93:793–820
Google Scholar - Kuypers HGJM, Szwarcbart MK, Mishkin M, Rosvold HE (1965) Occipitotemporal corticocortical connections in the rhesus monkey. Exp Neurol 11:245–262
Google Scholar - Pandya DN, Van Hoesen GW, Mesulam M-M (1981) Efferent connection of the cingulate gyrus in the rhesus monkey. Exp Brain Res 42:319–330
Google Scholar - Petrides M, Pandya DN (1984) Projections to the frontal cortex from the posterior parietal region in the rhesus monkey. J Comp Neurol 228:105–116
Google Scholar - Petrides M, Pandya DN (1988) Association fiber pathways to the frontal cortex from the superior temporal region in the rhesus monkey. J Comp Neurol 273:52–66
Google Scholar - Spiegler BJ, Mishkin M (1981) Evidence for the sequential participation of inferior temporal cortex and amygdala in the acquisition of stimulus-reward associations. Behav Brain Res 3:303–317
Google Scholar - Ungerleider LG, Desimone R (1986) Cortical connections of visual area MT in the macaque. J Comp Neurol 248:190–222
Google Scholar
Author information
Authors and Affiliations
- Laboratory of Neuropsychology, NIMH, Building 9, Room 1N107, 20892, Bethesda, MD, USA
L. G. Ungerleider & V. S. Pelak - Department of Experimental Psychology, Oxford University, OX1 3UD, Oxford, UK
D. Gaffan
Authors
- L. G. Ungerleider
You can also search for this author inPubMed Google Scholar - D. Gaffan
You can also search for this author inPubMed Google Scholar - V. S. Pelak
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Ungerleider, L.G., Gaffan, D. & Pelak, V.S. Projections from inferior temporal cortex to prefrontal cortex via the uncinate fascicle in rhesus monkeys.Exp Brain Res 76, 473–484 (1989). https://doi.org/10.1007/BF00248903
- Received: 09 September 1988
- Accepted: 16 February 1989
- Issue Date: August 1989
- DOI: https://doi.org/10.1007/BF00248903