Gm and Km frequencies in a Portugese population (original) (raw)

Summary

Serum samples from 79 healthy subjects and 31 patients with type I amyloid neuropathy were typed for nine Gm markers. No significant associations were found between any of the Gm phenotypes and the disease. The frequencies of the various phenotypes showed satisfactory agreement with the Hardy-Weinberg distribution. One individual had an unusual Gm phenotype.

Access this article

Log in via an institution

Subscribe and save

• Get 10 units per month
• Download Article/Chapter or eBook
• 1 Unit = 1 Article or 1 Chapter
• Cancel anytime Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

• Andrade C, Canijo M, Klein D, Kaelin A (1969) The genetic aspect of the familial amyloidotic polyneuropathy. Humangenetik 7:163–175
  Google Scholar
• Da Silva BM, Santarem MM, Arala-Chaves MP (1980) Evidence for high incidence of HLA-A2 and HLA-A9 in patients afflicted with type I (Andrade) amyloid neuropathy—preliminary studies. In: Glenner GG, e Costa PP, deFreitas AF (eds) Amyloid and amyloidosis. Excerpta Medica, Amsterdam, pp 125–130
  Google Scholar
• Fraser GR, Volkers WS, Bernini LF, van Loghem E, Khan PM, Nihenhuis LE (1974) Gene frequencies in a Dutch population. Hum Hered 24:435–448
  Google Scholar
• Grubb R (1970) The genetic markers of human immunoglobulins. Springer, Berlin Heidelberg New York
  Google Scholar
• Kurczynski TW, Steinberg AG (1967) A general program for maximum likelihood estimation of gene frequencies. Am J Hum Genet 19: 178–179
  Google Scholar
• Pandey JP, Fudenberg HH, Amos DB (1978) A Caucasian pedigree demonstrating the transmission of a Gm1,2,17,5,13,14 haplotype. J Immunogenet 5:1–4
  Google Scholar
• Pereira TM, Manso C (1975) Immunoglobulin allotypes in Portugal. Humangenetik 27:137–140
  Google Scholar
• Steinberg AG, Cook CE (1981) The distribution of the human immunoglobulin allotypes. Oxford University Press, New York
  Google Scholar
• Whittingham S, Mathews JD, Schanfield MS, Tait BD, Mackay IR (1981) Interaction of HLA and Gm in autoimmune chronic active hepatitis. Clin Exp Immunol 43:80–86
  Google Scholar
• Vyas GN, Fudenberg HH, Pretty HM, Gold ER (1968) A new rapid method for genetic typing of human immunoglobulins. J Immunol 100:274–279
  Google Scholar

Download references

Author information

Authors and Affiliations

1. Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina, 29425, Charleston, SC, USA
   J. P. Pandey, B. T. Shannon & H. H. Fudenberg
2. Departmento de Immunologia, Instituto de Ciencias Biomedicas “Abel Salazar”, Porto, Portugal
   M. P. Arala-Chaves

Authors

1. J. P. Pandey
   You can also search for this author inPubMed Google Scholar
2. B. T. Shannon
   You can also search for this author inPubMed Google Scholar
3. M. P. Arala-Chaves
   You can also search for this author inPubMed Google Scholar
4. H. H. Fudenberg
   You can also search for this author inPubMed Google Scholar

Additional information

Publication no. 526 from the Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina. Research supported in part by USPHS Grants CA-25746 and AI-07063, and by South Carolina State Appropriations for Research

Rights and permissions

About this article

Cite this article

Pandey, J.P., Shannon, B.T., Arala-Chaves, M.P. et al. Gm and Km frequencies in a Portugese population.Hum Genet 61, 154–156 (1982). https://doi.org/10.1007/BF00274207

Download citation

• Received: 15 February 1982
• Revised: 08 April 1982
• Issue Date: September 1982
• DOI: https://doi.org/10.1007/BF00274207

Keywords