Activity of steroid sulfatase in fibroblasts with numerical and structural X chromosome aberrations (original) (raw)

Summary

In cultured fibroblasts of patients with numerical and structural X chromosome aberrations the activity of steroid sulfatase (STS) is correlated with the number of functional STS gene copies. While normally, this X-linked gene is not inactivated, our data suggest that it may be subject to inactivation when carried on a structurally altered X-chromosome. Similar inactivation patterns have been reported earlier for the Xg locus which, like STS, is located on the distal protion of Xp.

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Authors and Affiliations

1. Institut für Humangenetik der Universität, Albertstr. 11, D-7800, Freiburg, Federal Republic of Germany
   H. H. Ropers, B. Migl & J. Zimmer
2. Istituto di Biologia Generale e Genetica Medica, Università di Pavia, C.P. 217, I-27100, Pavia, Italy
   M. Fraccaro & P. P. Maraschio
3. Department of Cell Biology and Genetics, Erasmus Universiteit, Postbus 1738, Rotterdam, The Netherlands
   A. Westerveld

Authors

1. H. H. Ropers
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2. B. Migl
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3. J. Zimmer
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4. M. Fraccaro
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5. P. P. Maraschio
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6. A. Westerveld
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Ropers, H.H., Migl, B., Zimmer, J. et al. Activity of steroid sulfatase in fibroblasts with numerical and structural X chromosome aberrations.Hum Genet 57, 354–356 (1981). https://doi.org/10.1007/BF00281683

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• Received: 04 February 1981
• Issue Date: July 1981
• DOI: https://doi.org/10.1007/BF00281683

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