Apolipoprotein E phenotypes in patients with myocardial infarction (original) (raw)

Summary

The frequencies of genetic apo E isoforms E2, E3 and E4 were determined in 523 patients with myocardial infarction and compared to those in a control group (1031 blood donors). A significant difference in the frequency of apo E4 was noted between patients and controls (0.05>_P_>0.025). No differences in the frequencies of isoforms E3 and E2 were observed. In particular, there was no significant difference between the two groups in the frequency of apo E2 homozygosity. a condition that is associated with type III hyperlipoproteinemia. However, all E2 homozygote survivors of myocardial infarction had hyperlipoproteinemia type III (cholesterol 269±29 mg/dl; triglyceride 419±150 mg/dl; age 54±14 years; _N_=5). On the contrary, E2 homozygote controls (all apo E-2/2 blood donors and their apo E-2/2 relatives who were from the same age range as the patients) had primary dysbetalipoproteinemia but normal or subnormal plasma cholesterol concentrations (cholesterol 184±28 mg/dl; triglyceride 151±52 mg/dl; age 56±13 years; _N_=11). This indicates that E2 homozygotes with hyperlipoproteinemia type III who occur rarely in the population but comprise about 1% of myocardial infarction patients have a markedly increase risk for coronary atherosclerosis, whereas the risk for E2 homozygotes with normal or subnormal plasma cholesterol (=primary dysbetalipoproteinemia) may be considerably lower than for the general population. The data illustrate the complex relationship between apo E genes, lipid levels, and risk for atherosclerosis.

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Authors and Affiliations

1. Institut für Humangenetik der Universität Marburg, Bahnhofstr. 7a, D-3550, Marburg/Lahn, Federal Republic of Germany
   G. Utermann
2. Zentrum für Innere Medizin der Universität Marburg, D-3550, Marburg/Lahn, Federal Republic of Germany
   A. Hardewig
3. Rehabilitationszentrum Bad Krozingen, D-7812, Bad Krozingen, Federal Republic of Germany
   F. Zimmer

Authors

1. G. Utermann
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2. A. Hardewig
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3. F. Zimmer
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Utermann, G., Hardewig, A. & Zimmer, F. Apolipoprotein E phenotypes in patients with myocardial infarction.Hum Genet 65, 237–241 (1984). https://doi.org/10.1007/BF00286509

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• Received: 31 May 1983
• Revised: 07 September 1983
• Issue Date: January 1984
• DOI: https://doi.org/10.1007/BF00286509

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