Inheritance of mitochondrial aldehyde dehydrogenase: genotyping in Chinese, Japanese and South Korean families reveals dominance of the mutant allele (original) (raw)

Summary

Genotyping of mitochondrial aldehyde dehydrogenase (ALDH I) was performed in enzymatically amplified DNA of 20 Chinese, Japanese and South Korean families (85 individuals) and in 113 unrelated persons by employing allele-specific oligonucleotide probes and dot blot hybridization. Genotyping individuals with phenotypic deficiency of ALDH I activity always showed the presence of at least one mutant allele. The data are compatible with a model assuming dominant inheritance of the mutant allele, which we have previously suggested on the basis of a population study.

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Authors and Affiliations

1. Institut für Humangenetik der Universität, Butenfeld 32, D-2000, Hamburg 54, Germany
   Surjit Singh, Gernot Fritze, Bingliang Fang, Rolf Eckey, Dharam P. Agarwal & H. Werner Goedde
2. Department of Community Medicine, University of Tsukuba, Tsukuba, Japan
   Shoji Harada
3. Department of Genetics, Hanyang University School of Medicine, 133-791, Seoul, South Korea
   Yong K. Paik

Authors

1. Surjit Singh
2. Gernot Fritze
3. Bingliang Fang
4. Shoji Harada
5. Yong K. Paik
6. Rolf Eckey
7. Dharam P. Agarwal
8. H. Werner Goedde

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Singh, S., Fritze, G., Fang, B. et al. Inheritance of mitochondrial aldehyde dehydrogenase: genotyping in Chinese, Japanese and South Korean families reveals dominance of the mutant allele.Hum Genet 83, 119–121 (1989). https://doi.org/10.1007/BF00286702

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• Received: 17 March 1989
• Revised: 27 April 1989
• Issue date: September 1989
• DOI: https://doi.org/10.1007/BF00286702

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