Estimation of liver tumor volume using different formulas—An experimental study in rats (original) (raw)

Summary

Experimental solitary ellipsoid liver tumors in the rat can be induced by inoculation of a tumor-cell suspension of known potency into the liver parenchyma. During laparotomy, the largest (a) and the smallest (b) superficial diameters of the tumor were measured on the surface of the liver with vernier calipers. Four different formulas have been tested and compared with the actual volume from the extirpated tumor and tumor weight. Within the size range of 15–700 mm3, based on the calculation of the difference between logarithmic tumor volume from the different formulas versus logarithmic volume of extirpated and dissected tumors and regression analyses, volume of the unremoved liver tumor can be best calculated according to the formula V=a x b 2/2.

Access this article

Log in via an institution

Subscribe and save

• Get 10 units per month
• Download Article/Chapter or eBook
• 1 Unit = 1 Article or 1 Chapter
• Cancel anytime Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

• Begg AC (1971) Kinetic and histological changes of serially transplanted mouse tumor. Cell Tissue Kinet 4:401–411
  Google Scholar
• Boyse EA, Old LJ, Thomas G (1962) A report on some observations with a simplified cytotoxic test. Transplant Bull 29:63–67
  Google Scholar
• Brues AM, Weiner AE, Andervont HB (1939) Relation between latent period and growth rate in chemically induced tumors. Proc Soc Exp Biol Med 42:374–377
  Google Scholar
• Chambers H, Scott GM (1930) Variations in the growth of the Jensen rat sarcoma and the influence of technique. J Pathol Bacteriol 33:553–561
  Google Scholar
• Dethlefsen LA, Prewitt JMS, Mendelsohn ML (1968) Analysis of tumor growth curves. J Natl Cancer Inst 40:389–405
  Google Scholar
• Fisher ER, Fisher B (1959a) Experimental studies of factors influencing hepatic metastases. I. The effect of number of tumor cells injected and time of growth. Cancer 12:926–928
  Google Scholar
• Fisher B, Fisher ER (1959b) Experimental studies of factors influencing hepatic metastases. III. Effect of surgical trauma with special reference to liver injury. Ann Surg 150:731–744
  Google Scholar
• Fisher B, Fisher ER (1959c) Experimental evidence in support of the dormant tumor cell. Science 130:918–919
  Google Scholar
• Fisher B, Fisher ER, Lee SH (1961) Effects of alteration of liver blood flow upon experimental hepatic metastases. Surg Gynecol Obstet 112:11–18
  Google Scholar
• Fisher B, Fisher ER (1961a) Experimental studies of factors influencing hepatic metastases. IV. Effect of nutrition. Cancer 14:547–554
  Google Scholar
• Fisher B, Fisher ER (1961b) Experimental studies of factors influencing hepatic metastases. VIII. Effect of anticoagulants. Surgery 50:240–247
  Google Scholar
• Fisher ER, Fisher B (1961c) Experimental studies of factors influencing hepatic metastases. VII. Effect of reticuloendothelial interference. Cancer Res 21:275–281
  Google Scholar
• Fisher ER, Fisher B (1962) Experimental studies of factors influencing hepatic metastases. X. Reticuloendothelial stimulation. Cancer Res 22:478–483
  Google Scholar
• Fisher B, Fisher ER (1963) Experimental studies of factors influencing hepatic metastases. XII. Effect of increased arterial blood flow. Proc Soc Exp Biol Med 112:126–128
  Google Scholar
• Hermens AF, Barendsen GW (1967) Cellular proliferation patterns in an experimental rhabdomyosarcoma in the rat. Eur J Cancer 3:361–369
  Google Scholar
• Kopper L, Steel GG (1975) The therapeutic response of three human tumor lines maintained in immune-suppressed mice. Cancer Res 35:2704–2713
  Google Scholar
• Lala PK (1971) Studies on tumor cell population kinetics. In: Busch H (ed) Methods in cancer research, vol 6. Academic Press, New York, pp 3–95
  Google Scholar
• McCredie JA, Inch WR, Kruuv J, Watson TA (1965) The rate of tumor growth in animals. Growth 29:331–347
  Google Scholar
• Marsh MC (1933) On an ambivalent effect of a single acute trauma on the growth of transplanted mouse tumors. Am J Cancer 17:735–742
  Google Scholar
• Mayneord WV (1932) On a law of growth of Jensen's rat sarcoma. Am J Cancer 16:841–846
  Google Scholar
• Moore JV, Dixon B (1977) Serial transplantation, histology and cellular kinetics of a rat adenocarcinoma. Cell Tissue Kinet 10:583–590
  Google Scholar
• Mottram JC (1935) On the origin of tar tumours in mice, whether from single cells or many cells. J Pathol Bacteriol 40:407–414
  Google Scholar
• Nilsson LAV, Zettergren L (1967) Effect of hepatic artery ligation on induced primary liver carcinoma in rats. Acta Pathol Microbiol Scand 71:187–193
  Google Scholar
• Schrek R (1935) A quantitative study of the growth of the Walker rat tumor and the Flexner-Jobling rat carcinoma. Am J Cancer 24:807–822
  Google Scholar
• Simpson-Herren L, Lloyd HH (1970) Kinetic parameters and growth curves for experimental tumor systems. Cancer Chemother Rep 54:143–174
  Google Scholar
• Steel GG, Adams K, Barrett JC (1966) Analysis of the cell population kinetics of transplanted tumours of widely-differing growth rate. Br J Cancer 20:784–800
  Google Scholar
• Steele G Jr, Sjögren HO (1974) Cross-reacting tumor-associated antigen(s) among chemically induced rat colon carcinomas. Cancer Res 34:1801–1807
  Google Scholar
• Willis RA (1968) Pathology of tumours, 4th edn. Butterworth, London
  Google Scholar

Download references

Author information

Authors and Affiliations

1. Department of Surgery, University of Lund, S-221 85, Lund, Sweden
   G. Carlsson & L. Hafström
2. South Swedish Regional Tumor Registry, University of Lund, S-221 85, Lund, Sweden
   B. Gullberg

Authors

1. G. Carlsson
   You can also search for this author inPubMed Google Scholar
2. B. Gullberg
   You can also search for this author inPubMed Google Scholar
3. L. Hafström
   You can also search for this author inPubMed Google Scholar

Additional information

Supported by grants from the Swedish Cancer Society, grant no 98-B80-15XA, John and Augusta Persson's Foundation for Cancer Research, Segerfalk's Foundation, the Medical Faculty of the University of Lund

Rights and permissions

About this article

Cite this article

Carlsson, G., Gullberg, B. & Hafström, L. Estimation of liver tumor volume using different formulas—An experimental study in rats.J Cancer Res Clin Oncol 105, 20–23 (1983). https://doi.org/10.1007/BF00391826

Download citation

• Received: 12 March 1982
• Accepted: 23 August 1982
• Issue Date: January 1983
• DOI: https://doi.org/10.1007/BF00391826

Key words