Mapping of human X-linked hypophosphataemic rickets by multilocus linkage analysis (original) (raw)

Summary

Eleven families with X-linked dominant hypophosphataemic rickets (HPDR) have been typed for a series of X chromosome markers. Linkage with probe 99.6 (DXS41) was demonstrated with a peak lod score of 4.82 at 10% recombination. Multilocus linkage analysis showed that HPDR maps distal to 99.6; this probe has previously been located at Xp22.31-p21.3 by in situ hybridisation. In the mouse hypophosphataemia (Hyp) maps to the distal part of the X chromosome; our location in man is consistent with a scheme which relates the mouse and human X chromosomes by two rearrangements. No marker has yet been found which shows no recombination with HPDR.

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Authors and Affiliations

1. Department of Medical Genetics, St. Mary's Hospital, M13 0JH, Manchester, UK
   A. P. Read, R. C. Mountford, R. Harris & C. J. Peacock
2. Department of Medicine, The Middlesex Hospital, W1N 8AA, London, UK
   R. V. Thakker, D. P. Brenton, G. N. Hendy & J. L. H. O'Riordan
3. Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, OX3 9DU, Oxford, UK
   K. E. Davies, A. King, S. McGlade & R. Smith
4. Department of Medicine, Manchester Royal Infirmary, Manchester 13, UK
   M. Davies
5. Shriner's Hospital, Montreal, Canada
   F. Glorieux

Authors

1. A. P. Read
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2. R. V. Thakker
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3. K. E. Davies
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4. R. C. Mountford
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5. D. P. Brenton
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6. M. Davies
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7. F. Glorieux
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8. R. Harris
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9. G. N. Hendy
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10. A. King
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11. S. McGlade
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12. C. J. Peacock
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13. R. Smith
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14. J. L. H. O'Riordan
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Read, A.P., Thakker, R.V., Davies, K.E. et al. Mapping of human X-linked hypophosphataemic rickets by multilocus linkage analysis.Hum Genet 73, 267–270 (1986). https://doi.org/10.1007/BF00401242

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• Received: 20 January 1986
• Issue Date: July 1986
• DOI: https://doi.org/10.1007/BF00401242

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