Butyrate: a cytotoxin for Vero cells produced by Bacteroides gingivalis and Bacteroides asaccharolyticus (original) (raw)
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Abstract
Culture filtrates of B. gingivalis and B. asaccharolyticus are cytotoxic for Vero cells. It is shown that the cytotoxic effect is due to the butyrate concentrations present in the culture filtrates of these strains. This cytotoxic effect proved to be reversible. Strains of the B. melaninogenicus subspecies intermedius and melaninogenicus did not produce butyrate and did not show cytotoxic activity towards Vero Cells.
The significance of the production of toxic concentrations of butyrate for the etiology of especially periodontal diseases is discussed.
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Authors and Affiliations
- Department of Oral Microbiology, School of Dentistry, Vrije Universiteit, Amsterdam, The Netherlands
J. J. A. Touw, T. J. M. van Steenbergen & J. de Graaff
Authors
- J. J. A. Touw
- T. J. M. van Steenbergen
- J. de Graaff
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Touw, J.J.A., van Steenbergen, T.J.M. & de Graaff, J. Butyrate: a cytotoxin for Vero cells produced by Bacteroides gingivalis and Bacteroides asaccharolyticus.Antonie van Leeuwenhoek 48, 315–325 (1982). https://doi.org/10.1007/BF00418285
- Received: 15 January 1982
- Issue date: July 1982
- DOI: https://doi.org/10.1007/BF00418285