Factor VIII related antigen as an endothelial cell marker in benign and malignant diseases (original) (raw)

Summary

The presence and distribution of Factor VIII related antigen (FVIIIR:Ag) in formalin fixed, paraffin embedded tissue were studied in benign and malignant vascular tumors, inflammatory vascular diseases, normal tissue from various organs and a number of malignant tumors. The unlabeled peroxidase-anti-peroxidase method was utilized. Immunostaining was observed only in endothelial cells, in tumor cells of endothelial cell origin and in megakaryocytes and platelets. The staining method gave a distinct picture of the vascular pattern in all types of tissue examined. The demonstration of FVIIIR: Ag by means of the immunoperoxidase technique is considered a valuable method in diagnosing tumors of vascular origin. The method also facilitates detection of vascular invasion of malignant tumors in small caliber vessels.

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Authors and Affiliations

1. Department of Pathology, Finsen Institute, Strandboulevarden 49, DK-2100, Copenhagen, Denmark
   Maxwell Sehested & Klaus Hou-Jensen

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1. Maxwell Sehested
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2. Klaus Hou-Jensen
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Sehested, M., Hou-Jensen, K. Factor VIII related antigen as an endothelial cell marker in benign and malignant diseases.Virchows Arch. A Path. Anat. and Histol. 391, 217–225 (1981). https://doi.org/10.1007/BF00437598

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• Accepted: 12 November 1980
• Issue Date: April 1981
• DOI: https://doi.org/10.1007/BF00437598

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