Human stratum corneum polar lipids and desquamation (original) (raw)

Summary

The ceramides and steryl-sulfate components from desquamated and cohesive human stratum corneum were examined using a combination of chemical and chromatographic means. Six structurally distinct series of ceramides were identified, and the relative amounts of these species, as measured by quantitative thin-layer chromatography, did not differ in cohesive and desquamated stratum corneum. In contrast, the level of cholesteryl sulfate was significantly reduced in the desquamated material. The results are in accord with the hypothesis that cholesteryl sulfate serves in cell-to-cell cohesion within the stratum corneum, and its hydrolysis may be necessary to permit shedding of cells from the surface.

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Authors and Affiliations

1. The Marshall Dermatology Research Laboratories, University of Iowa College of Medicine, 52242-1090, Iowa City, Iowa, USA
   S. A. Long, P. W. Wertz, J. S. Strauss & D. T. Downing

Authors

1. S. A. Long
2. P. W. Wertz
3. J. S. Strauss
4. D. T. Downing

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Long, S.A., Wertz, P.W., Strauss, J.S. et al. Human stratum corneum polar lipids and desquamation.Arch Dermatol Res 277, 284–287 (1985). https://doi.org/10.1007/BF00509081

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• Received: 27 August 1984
• Issue date: July 1985
• DOI: https://doi.org/10.1007/BF00509081

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