Impairment of insulin secretion in man by nifedipine (original) (raw)

Summary

The effect of nifedipine, a calcium antagonist, on carbohydrate metabolism and insulin secretion was evaluated in patients who required treatment with this drug. 20 subjects underwent two oral glucose tolerance tests (100 g), one under basal conditions, and the other after ten days of treatment with nifedipine 30 mg/day by mouth, in three divided doses. 10 subjects had normal glucose tolerance; in them nifedipine administration reduced the insulin response to oral glucose in the first 60 min, but improved glucose tolerance. The other 10 subjects had impaired glucose tolerance and nifedipine treatment resulted in a further reduction both of insulin secretion and glucose tolerance. No such effects were seen in the placebo (weight- and disease-matched) group. The mechanism by which nifedipine influences carbohydrate metabolism and insulin secretion is discussed.

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References

  1. Lochner W, Braasch W, Kroneberg G (1975) 2nd International Adalat Symposium. Amsterdam 1974. Springer, Berlin Heidelberg New York
  2. Fleckenstein A, Tritthart H, Döring HJ, Byon K (1972) BAY a 1040 — ein hochaktiver Ca++-antagonostischer Inhibitor der elektro-mechanischen Koppelungsprozesse im Warmblüter Myokard. Arzneim Forsch (Drug Res) 22: 22–33
    Google Scholar
  3. Eto S, Mood JM, Hutchins M, Fleischer N (1974) Pituitary 45 Ca++-uptake and release of ACTH, GH and TSH. Effect of verapamil. Am J Physiol 226: 1315–1320
    Google Scholar
  4. Nayler WG, Szeto J (1972) Effect of verapamil on contractility, oxigen utilization and calcium exchangeability in mammalian heart muscle. Cardiovasc Res 6: 120–128
    Google Scholar
  5. Devis G, Somers G, Van Obberghen E, Malaisse WJ (1975) Calcium antagonists and islets function. I. Inhibition by verapamil. Diabetes 24: 547–551
    Google Scholar
  6. Leclercq-Meyer V, Marchand J, Malaisse WJ (1978) The role of calcium in glucagon release. Studies with verapamil. Diabetes 27: 996–1004
    Google Scholar
  7. Somers G, Devis G, Van Obberghen E, Malaisse WJ (1977) Calcium antagonists and islets function. II. Interaction of theophylline and verapamil. Endocrinology 99: 114–124
    Google Scholar
  8. Somers G, Devis G, Van Obberghen E, Malaisse WJ (1976) Calcium antagonists and islet function. VI. Effect of barium. Pflügers Arch 365: 21–28
    Google Scholar
  9. Wilkerson HCL (1964) Diagnosis, oral glucose tolerance tests. In: Diabetes mellitus: diagnosis and treatment. American Diabetes Association, New York, pp 31–34
    Google Scholar
  10. Giugliano D, Torella R, Sgambato S, D'Onofrio F (1979) Effects of alpha and beta adrenergic inhibition and somatostatin on plasma glucose, FFA, insulin, glucagon and growth hormone responses to PGE1 in man. J Clin Endocrinol Metab 48: 302–308
    Google Scholar
  11. Lydtin H, Lohmöller G, Lohmöller H, Schmitz H, Walter I (1976) Comparative hemodynamic studies with Adalat and other antianginal durg. In: Jatene AD, Lichtlen PR (eds) 3rd International Adalt Symposium. Excerpta Medica, Amsterdam, pp 98–106
    Google Scholar
  12. Curry DL, Bennett LL, Grodsky GM (1968) Requirement for calcium ion in insulin secretion by the perfused rat pancreas. Am J Physiol 214: 174–178
    Google Scholar
  13. Hellman B (1975) The significance of calcium for glucose-stimulation of insulin release. Endocrinology 97, 392–398
    Google Scholar
  14. Röjdmark S (1979) Effect of verapamil on insulin response to alcohol hypoglycemia in patients with primary hyperparathyroidism. Diabetes 28: 20–25
    Google Scholar
  15. Posner P, Miller BL, Lambert CR (1975) The effect of verapamil on potassium fluxes in canine cardiac Purkinje fibers. Eur J Pharmacol 34: 369–372
    Google Scholar

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Authors and Affiliations

  1. Institute of Medical Pathology and Clinical Methodology, 1st Faculty of Medicine, University of Naples, Italy
    D. Giugliano, R. Torella, F. Cacciapuoti, S. Gentile, M. Verza & M. Varricchio

Authors

  1. D. Giugliano
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  2. R. Torella
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  3. F. Cacciapuoti
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  4. S. Gentile
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  5. M. Verza
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  6. M. Varricchio
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Giugliano, D., Torella, R., Cacciapuoti, F. et al. Impairment of insulin secretion in man by nifedipine.Eur J Clin Pharmacol 18, 395–398 (1980). https://doi.org/10.1007/BF00636791

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