Bishop JM: Molecular themes in oncogenesis. Cell 64: 235–248, 1991 Google Scholar
Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S: Oncogenes and signal transduction. Cell 64: 281–302, 1991 Google Scholar
Cross M, Dexter TM: Growth factors in development, transformation, and tumorigenesis. Cell 64: 271–280, 1991 Google Scholar
Aaronson SA: Growth factors and cancer. Science 254: 1146–1153, 1991 Google Scholar
Massagué J: The transforming growth factor-β family. Annu Rev Cell Biol 6: 597–641, 1990 Google Scholar
Massagué J, Cheifetz S, Laiho M, Ralph DA, Weis FMB, Zentella A: Transforming growth factor-β. Cancer Surv 12: 81–103, 1992 Google Scholar
Roberts AB, Sporn MB: The transforming growth factor-βs. In: Peptide growth factors and their receptors/Handbook of Experimental Pharmacology. Springer-Verlag Heidelberg 95: 419–472, 1990 Google Scholar
Lyons RM, Moses HL: Transforming growth factors and the regulation of cell proliferation. Eur J Biochem 187: 467–473, 1990 Google Scholar
Melhem MF, Meisler AI, Finley GG, Bryce WH, Jones MO, Tribby II, Pipas JM, Koski RA: Distribution of cells expressing myc proteins in human colorectal eipthelium, polyps, and malignant tumors. Cancer Res 52: 5853–5864, 1992 Google Scholar
Sarubbi DJ, Narayanan R, Telang NT, Newman MJ: Evaluation of the role of extracellular matrix proteins, polyunsaturated fatty acids and c-myc expression in the inhibition of the serum-free growth of epithelial cells by TGF-β1. In Vitro Cell Dev Biol 26: 1195–1201, 1990 Google Scholar
Longstreet M, Miller B, Howe PH: Loss of transforming growth factor beta 1 (TGF-beta 1)-induced growth arrest and p34cdc2 regulation in ras-transfected epithelial cells. Oncogene 7: 1549–1556, 1992 Google Scholar
Reiss M, Dibble CL, Narayanan R: Transcriptional activation of the_c-myc_ proto-oncogene in murine keratinocytes enhances the response to epidermal growth factor. J Invest Dermatol 93: 136–141, 1989 Google Scholar
Laiho M, DeCaprio JA, Ludlow JW, Livingston DM, Massagué J: Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation. Cell 62: 175–185, 1990 Google Scholar
Abraham SE, Carter MC, Moran E: Transforming growth factor β1 (TGFβ1) reduces cellular levels of p34cdc2, and this effect is abrogated by adenovirus independently of the E1A-associated pRB binding activity. Mol Biol Cell 3: 655–665, 1992 Google Scholar
Zentella A, Weis FMB, Ralph DA, Laiho M, Massagué J: Early gene responses to transforming growth factor-β in cells lacking growth-suppressive RB function. Mol Cell Biol 11: 4952–4958, 1991 Google Scholar
Wilding G, Zugmeier G, Knabbe C, Flanders K, Gelmann E: Differential effects of transforming growth factor β on human prostate cancer cells_in vitro_. Mol Cell Endocrinol 62: 79–87, 1989 Google Scholar
Lokeshwar BL, Block NL: Isolation of a prostate carcinoma cell proliferation-inhibiting factor from human seminal plasma and its similarity to transforming growth factor β. Cancer Res 52: 5821–5825, 1992 Google Scholar
Ong G, Sikora K, Gullick WJ: Inactivation of the retinoblastoma gene does not lead to loss of TGF-β receptors or response to TGF-β in breast cancer cell lines. Oncogene 6: 761–763, 1991 Google Scholar
Gerwin BI, Spillare E, Forrester K, Lehman TA, Kispert J, Welsh JA, Pfeifer AM, Lechner JF, Baker SJ, Vogelstein B: Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1. Proc Natl Acad Sci USA 89: 2759–2763, 1992 Google Scholar
Reiss M, Vellucci VF, Zhou ZL: Mutant p53 tumor suppressor gene causes resistance to transforming growth factor beta 1 in murine keratinocytes. Cancer Res 53: 899–904, 1993 Google Scholar
Nathan C, Sporn M: Cytokines in context. J Cell Biol 113: 981–986, 1991 Google Scholar
Roberts AB, McCune BK, Sporn MB: TGF-β: regulation of extracellular matrix. Kidney Int 41: 557–559, 1992 Google Scholar
Ignotz RA: TGF-beta and extracellular matrix related influences on gene expression and phenotype. Crit Rev Eukaryot Gene Expr 1: 75–84, 1991 Google Scholar
Nugent MA, Newman MJ: Inhibition of normal rat kidney cell growth by transforming growth factor-β is mediated by collagen. J Biol Chem 264: 18060–18067, 1989 Google Scholar
Juliano RL, Haskill S: Signal transduction from the extracellular matrix. J Cell Biol 120: 577–585, 1993 Google Scholar
Carey DJ: Control of growth and differentiation of vascular cells by extracellular matrix proteins. Annu Rev Physiol 53: 161–177, 1991 Google Scholar
Gospodarowicz D, Greenburg G, Birdwell CR: Determination of cellular shape by the extracellular matrix and its correlation with the control of cellular growth. Cancer Res 38: 4155–4171, 1978 Google Scholar
Yang B-S, Geddes TJ, Pogulis RJ, de Crombrugghe B, Freytag SO: Transcriptional suppression of cellular gene expression by c-Myc. Mol Cell Biol 11: 2291–2295, 1991 Google Scholar
Green H, Todaro GJ, Goldberg B: Collagen synthesis in fibroblasts transformed by oncogenic viruses. Nature 209: 916–917, 1966 Google Scholar
Krieg T, Aumailley M, Dessau W, Wiestner M, Müller P: Synthesis of collagen by human fibroblasts and their SV40 transformants. Exp Cell Res 125: 23–30, 1980 Google Scholar
Smith BD, Niles R: Characterization of collagen synthesized by normal and chemically transformed rat liver epithelial cell lines. Biochemistry 19: 1820–1825, 1980 Google Scholar
Bateman JF, Peterkofsky B: Mechanisms of Kirsten murine sarcoma virus transformation-induced changes in the collagen phenotype and synthetic rate of BALB 3T3 cells. Proc Natl Acad Sci USA 78: 6028–6032, 1981 Google Scholar
Carter WG: Transformation-dependent alterations in glycoproteins of the extracellular matrix of human fibroblasts. J Biol Chem 257: 13805–13815, 1982 Google Scholar
Marsilio E, Sobel ME, Smith BD: Absence of procollagen alpha 2(I) mRNA in chemically transformed rat liver epithelial cells. J Biol Chem 259: 1401–1404, 1984 Google Scholar
Setoyama C, Liau G, de Crombrugghe B: Pleiotropic mutants of NIH 3T3 cells with altered regulation in the expression of both type I collagen and fibronectin. Cell 41: 201–209, 1985 Google Scholar
Bornstein P, Sage H: Regulation of collagen gene expression. Prog Nucleic Acid Res Mol Biol 37: 67–106, 1989 Google Scholar
Slack JL, Parker MI, Robinson VR, Bornstein P: Regulation of collagen I gene expression by_ras_. Mol Cell Biol 12: 4714–4723, 1992 Google Scholar
Liotta LA, Steeg PS, Stetler-Stevenson WG: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64: 327–336, 1991 Google Scholar
Lester BR, McCarthy JB: Tumor cell adhesion to the extracellular matrix and signal transduction mechanisms implicated in tumor cell motility, invasion and metastasis. Cancer Metastasis Rev 11: 31–44, 1992 Google Scholar
Kerbel RS: Expression of multi-cytokine resistance and multi-growth factor independence in advanced stage metastatic cancer: malignant melanoma as a paradigm. Am J Pathol 141: 519–524, 1992 Google Scholar
Filmus J, Kerbel RS: Development of resistance mechanisms to the growth-inhibitory effects of transforming growth factor-beta during tumor progression. Curr Opin Oncol 5: 123–129, 1993 Google Scholar
Newman MJ, Nugent MA, Wang SY: Loss of growth inhibition by transforming growth factor-beta-1 (TGF-beta-1) and aberrant expression of alpha 2 type I collagen in spontaneously transformed and virus-transformed normal rat kidney cells (Abstract). Meeting On Wound Repair Held At The 20Th Annual Meeting Of The Keystone Symposia On Molecular And Cellular Biology, Keystone, Colorado, USA, April 1–7, 1991. J Cell Biochem Suppl (15 Part F) 172, 1991 Google Scholar
Newman MJ, Lane EA, Nugent MA, Racker E: Induction of anchorage-independent growth by epidermal growth factor and altered sensitivity to type β transforming growth factor in partially transformed rat kidney cells. Cancer Res 46: 5842–5850, 1986 Google Scholar
Nugent MA, Lane EA, Keski-Oja J, Moses HL, Newman MJ: Growth stimulation, altered regulation of epidermal growth factor receptors, and autocrine transformation of spontaneously transformed normal rat kidney cells by transforming growth factor β. Cancer Res 49: 3884–3890, 1989 Google Scholar
Newman MJ, Lane EA, Iannotti AM, Nugent MA, Pepinsky RB, Keski-Oja J: Characterization and purification of a secreted plasminogen activator inhibitor (PAI-1) induced by transforming growth factor-β1 in normal rat kidney (NRK) cells: decreased PAI-1 expression in transformed NRK cells. Endocrinology 126: 2936–2946, 1990 Google Scholar
Schwarz LC, Wright JA, Gingras MC, Kondaiah P, Danielpour D, Pimentel M, Sporn MB, Greenberg AH: Aberrant TGF-beta production and regulation in metastatic malignancy. Growth Factors 3: 115–127, 1990 Google Scholar
Leof EB, Proper JA, Goustin AS, Shipley GD, DiCorleto PE, Moses HL: Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity. Proc Natl Acad Sci USA 83: 2453–2457, 1986 Google Scholar
Battegay EJ, Raines EW, Seifert RA, Bowen-Pope DF, Ross R: TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop. Cell 63: 515–524, 1990 Google Scholar
Roberts AB, Anzano MA, Lamb LC, Smith JM, Sporn MB: New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues. Proc Natl Acad Sci USA 78: 5339–5343, 1981 Google Scholar
Brown KD, Holley RW: Insulin-like synergistic stimulation of DNA synthesis in Swiss 3T3 cells by the BSC-1 cell-derived growth inhibitor related to transforming growth factor type beta. Proc Natl Acad Sci USA 84: 3743–3747, 1987 Google Scholar
Janat MF, Liau G: Transforming growth factor β1 is a powerful modulator of platelet-derived growth factor action in vascular smooth muscle cells. J Cell Physiol 150: 232–242, 1992 Google Scholar
Roberts AB, Anzano MA, Wakefield LM, Roche NS, Stern DF, Sporn MB: Type β transforming growth factor: a bifunctional regulator of cellular growth. Proc Natl Acad Sci USA 82: 119–123, 1985 Google Scholar
Assoian RK, Frolik CA, Roberts AB, Miller DM, Sporn MB: Transforming growth factor-β controls receptor levels for epidermal growth factor in NRK fibroblasts. Cell 36: 35–41, 1984 Google Scholar
Massagué J: Transforming growth factor-β modulates the high-affinity receptors for epidermal growth factor and transforming growth factor-α. J Cell Biol 100: 1508–1514, 1985 Google Scholar
Takehara K, LeRoy EC, Grotendorst GR: TGF-β inhibition of endothelial cell proliferation: alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression. Cell 49: 415–422, 1987 Google Scholar
Kawamoto T, Nishi M, Takahashi K, Nishiyama T, Sato JD, Taniguchi S: Stimulation by transforming growth factor-β of epidermal growth factor-dependent growth of aged human fibroblasts: recovery of high affinity EGF receptors and growth stimulation by EGF. In Vitro Cell Dev Biol 25: 965–970, 1989 Google Scholar
Baskin G, Schenker S, Frosto T, Henderson G: Transforming growth factor β1 inhibits epidermal growth factor receptor endocytosis and down-regulation in cultured fetal rat hepatocytes. J Biol Chem 266: 13238–13242, 1991 Google Scholar
Assoian RK: Biphasic effects of type β transforming growth factor on epidermal growth factor receptors in NRK fibroblasts. J Biol Chem 260: 9613–9617, 1985 Google Scholar
Raghow R: Role of transforming growth factor-β in repair and fibrosis. Chest 99 Suppl.: 61S-65S, 1991 Google Scholar
Wahl SM: The role of transforming growth factor-beta in inflammatory processes. Immunol Res 10: 249–254, 1991 Google Scholar
Bryant R: Wound repair: a review. J Enterostomal Ther 14: 262–266, 1987 Google Scholar
Kane CJM, Hebda PA, Mansbridge JN, Hanawalt PC: Direct evidence for spatial and temporal regulation of transforming growth factor β1 expression during cutaneous wound healing. J Cell Physiol 148: 157–173, 1991 Google Scholar
Dvorak HF: Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315: 1650–1659, 1986 Google Scholar
Arrick BA, Lopez AR, Elfman F, Ebner R, Damsky CH, Derynck R: Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor β1. J Cell Biol 118: 715–726, 1992 Google Scholar
Arteaga CL, Carty-Dugger T, Moses HL, Hurd SD, Pietenpol JA: Transforming growth factor β1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice. Cell Growth Differentiation 4: 193–201, 1993 Google Scholar
Welch DR, Fabra A, Nakajima M: Transforming growth factor β stimulates mammary adenocarcinoma cell invasion and metastatic potential. Proc Natl Acad Sci USA 87: 7678–7682, 1990 Google Scholar
Ueki N, Nakazato M, Ohkawa T, Ikeda T, Amuro Y, Hada T, Higashino K: Excessive production of transforming growth-factor β1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth. Biochim Biophys Acta Mol Cell Res 1137: 189–196, 1992 Google Scholar
Sieweke MH, Thompson NL, Sporn MB, Bissell MJ: Mediation of wound-related Rous sarcoma virus tumorigenesis by TGF-β. Science 248: 1656–1660, 1990 Google Scholar
Torre-Amione G, Beauchamp RD, Koeppen H, Park BH, Schreiber H, Moses HL, Rowley DA: A highly immunogenic tumor transfected with a murine transforming growth factor type β1 cDNA escapes immune surveillance. Proc Natl Acad Sci USA 87: 1486–1490, 1990 Google Scholar
Keski-Oja J, Lyons RM, Moses HL: Immunodetection and modulation of cellular growth with antibodies against native transforming growth factor-β. Cancer Res 47: 6451–6458, 1987 Google Scholar
Schlessinger J: The epidermal growth factor receptor as a multifunctional allosteric protein. Biochem 27: 3119–3123, 1988 Google Scholar
Wells A, Welsh JB, Lazar CS, Wiley HS, Gill GN, Rosenfeld MG: Ligand-induced transformation by a noninternalizing epidermal growth factor receptor. Science 247: 962–964, 1990 Google Scholar
Todaro GJ, De Larco JE: Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells. Nature 264: 26–31, 1976 Google Scholar
De Larco JE, Todaro GJ: Growth factors from murine sarcoma virus-transformed cells. Proc Natl Acad Sci USA 75: 4001–4005, 1978 Google Scholar
Chua CC, Geiman DE, Schreiber AB, Ladda RL: Nonfunctional epidermal growth factor receptor in cells transformed by kirsten sarcoma virus. Biochem Biophys Res Commun 118: 538–547, 1984 Google Scholar
Westermark B, Heldin CH: Platelet-derived growth factor in autocrine transformation. Cancer Res 51: 5087–5092, 1991 Google Scholar
Mercola D, Carpenter PM, Grover-Bardwick A, Mercola M: Rapid, complete and reversible transformation by v-sis precedes irreversible transformation. Oncogene 7: 1793–1803, 1992 Google Scholar
Yayon A, Klagsbrun M: Autocrine regulation of cell growth and transformation by basic fibroblast growth factor. Cancer Metastasis Rev 9: 191–202, 1990 Google Scholar
Olashaw NE, Pledger WJ: Heterologous regulation of EGF receptors in fibroblastic cells. J Cell Biochem 34: 143–149, 1987 Google Scholar
King AC, Cuatrecasas P: Resolution of high and low affinity epidermal growth factor receptors. Inhibition of high affinity component by low temperature, cycloheximide, and phorbol esters. J Biol Chem 257: 3053–3060, 1982 Google Scholar
Backer JM, King GL: Regulation of receptor-mediated endocytosis by phorbol esters. Biochem Pharmacol 41: 1267–1277, 1991 Google Scholar
Livneh E, Dull TH, Berent E, Prywes R, Ullrich A, Schlessinger J: Release of a phorbol ester-induced mitogenic block by mutation at Thr-654 of the epidermal growth factor receptor. Mol Cell Biol 8: 2302–2308, 1988 Google Scholar
Countaway JL, McQuilkin P, Gironès N, Davis RJ: Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation. J Biol Chem 265: 3407–3416, 1990 Google Scholar
Beguinot L, Hanover JA, Ito S, Richert ND, Willingham MC, Pastan I: Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors. Proc Natl Acad Sci USA 82: 2774–2778, 1985 Google Scholar
Massagué J: Receptors for the TGF-beta family. Cell 69: 1067–1070, 1992 Google Scholar
Chua CC, Ladda RL: Protein kinase C and non-functional EGF receptor in K-ras transformed cells. Biochem Biophys Res Commun 135: 435–444, 1986 Google Scholar
Markovac J, Goldstein GW: Transforming growth factor beta activates protein kinase C in microvessels isolated from immature rat brain. Biochem Biophys Res Commun 150: 575–582, 1988 Google Scholar
Wrenn RW, Raeuber CL, Herman LE, Walton WJ, Rosenquist TH: Transforming growth factor-beta: signal transduction via protein kinase C in cultured embryonic vascular smooth muscle cells. In Vitro Cell Dev Biol 29A: 73–78, 1993 Google Scholar
Bomsel M, Mostov K: Role of heterotrimeric G proteins in membrane traffic. Mol Biol Cell 3: 1317–1328, 1992 Google Scholar
Houslay MD: ‘Crosstalk’: a pivotal role for protein kinase C in modulating relationships between signal transduction pathways. Eur J Biochem 195: 9–27, 1991 Google Scholar
Wu SP, Sun L-Z, Willson JKV, Humphrey L, Kerbel R, Brattain MG: Repression of autocrine transforming growth factor β1 and β2 in quiescent CBS colon carcinoma cells leads to progression of tumorigenic properties. Cell Growth Differentiation 4: 115–123, 1993 Google Scholar
Lu C, Vickers MF, Kerbel RS: Interleukin 6: a fibroblastderived growth inhibitor of human melanoma cells from early but not advanced stages of tumor progression. Proc Natl Acad Sci USA 89: 9215–9219, 1992 Google Scholar
Lu C, Kerbel RS: Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression. J Cell Biol 120: 1281–1288, 1993 Google Scholar
Cuttitta F, Carney DN, Mulshine J, Moody TW, Fedorko J, Fischler A, Minna JD: Bombesin-like peptides can fuction as autocrine growth factors in human small-cell lung cancer. Nature 316: 823–826, 1985 Google Scholar
Zachary I, Rozengurt E: Modulation of the epidermal growth factor receptor by mitogenic ligands: effects of bombesin and role of protein kinase C. Cancer Surv 4: 729–765, 1985 Google Scholar
Moehring TJ, Moehring JM: Response of cultured mammalian cells to diphtheria toxin. IV. Isolation of KB cells resistant to diphtheria toxin. Infect Immun 6: 487–492, 1972 Google Scholar
Robbins AR, Peng SS, Marshall JL: Mutant Chinese hamster ovary cells pleiotropically defective in receptor-mediated endocytosis. J Cell Biol 96: 1064–1071, 1983 Google Scholar
Merion M, Schlesinger P, Brooks RM, Moehring JM, Moehring TJ, Sly WS: Defective acidification of endosomes in Chinese hamster ovary cell mutants ‘cross-resistant’ to toxins and viruses. Proc Natl Acad Sci USA 80: 5315–5319, 1983 Google Scholar
Robbins AR, Oliver C, Bateman JL, Krag SS, Galloway CJ, Mellman I: A single mutation in Chinese hamster ovary cells impairs both Golgi and endosomal functions. J Cell Biol 99: 1296–1308, 1984 Google Scholar
Newman MJ: Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor β is dependent on the presence of polyunsaturated fatty acids. Proc Natl Acad Sci USA 87: 5543–5547, 1990 Google Scholar
Parekh TV, Sarubbi DJ, Newman MJ: Malignant transformation is correlated with acquisition of sensitivity to transforming growth factor beta-1 and polyunsaturated fatty acid-mediated cytotoxicity (Abstract). 83Rd Annual Meeting Of The American Association For Cancer Research, San Diego, California, USA, May 20–23, 1992. Proc Am Assoc Cancer Res Annu Meet 33: 149, 1992 Google Scholar
Raines EW, Ross R: Platelet-derived growth factor. I. High yield purification and evidence for multiple forms. J. Biol Chem 257: 5154–5260, 1982 Google Scholar