Vascular permeability factor (VPF, VEGF) in tumor biology (original) (raw)
References
Underwood JC, Carr I: The ultrastructure and permeability characteristics of the blood vessels of a transplantable rat sarcoma. J Pathol 107: 157–166, 1972 Google Scholar
Peterson H-I: Tumor Blood Circulation: Angiogenesis, Vascular Morphology and Blood Flow of Experimental and Human Tumors. CRC Press, Inc., Boca Raton, 1979, 229 Google Scholar
Dvorak HF: Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315: 1650–1659, 1986 Google Scholar
Nagy JA, Brown LF, Senger DR, Lanir N, Van De Water L, Dvorak AM, Dvorak HF: Pathogenesis of tumor stroma generation: A critical role for leaky blood vessels and fibrin deposition. Biochim Biophys Acta 948: 305–326, 1988 Google Scholar
Dvorak HF, Nagy JA, Dvorak JT, Dvorak AM: Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am J Pathol 133: 95–109, 1988 Google Scholar
Dvorak HF, Nagy JA, Dvorak AM: Structure of solid tumors and their vasculature: Implications for therapy with monoclonal antibodies. Cancer Cells 3: 77–85, 1991 Google Scholar
Dvorak HF, Orenstein NS, Carvalho AC, Churchill WH, Dvorak AM, Galli SJ, Feder J, Bitzer AM, Rypysc J, Giovinco P: Induction of a fibrin-gel investment: An early event in line 10 hepatocarcinoma growth mediated by tumor-secreted products. J Immunol 122: 166–174, 1979 Google Scholar
Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF: Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219: 983–985, 1983 Google Scholar
Senger DR, Perruzzi CA, Feder J, Dvorak HF: A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res 46: 5629–5632, 1986 Google Scholar
Dvorak HF, Nagy JA, Berse B, Brown LF, Yeo K-T, Yeo T-K, Dvorak AM, Van De Water L, Sioussat TM, Senger DR: Vascular permeability factor, fibrin, and the pathogenesis of tumor stroma function. Ann NY Acad Sci 667: 101–111, 1992 Google Scholar
Ferrara N, Henzel WJ: Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. BBRC 161: 851–858, 1989 Google Scholar
Gospodarowicz D, Abraham JA, Schilling J: Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proc Natl Acad Sci USA 86: 7311–7315, 1989 Google Scholar
Senger DR, Connolly D, Perruzzi CA, Alsup D, Nelson R, Leimgruber R, Feder J, Dvorak HF: Purification of a vascular permeability factor (VPF) from tumor cell conditioned medium. Federation Proceedings 1987: 2102
Connolly DT, Olander JV, Heuvelman D, Nelson R, Monsell R, Siegel N, Haymore BL, Leimgruber R, Feder J: Human vascular permeability factor. Isolation from U937 cells. J Biol Chem 264: 20017–20024, 1989 Google Scholar
Senger DR, Connolly DT, Van De Water L, Feder J, Dvorak HF: Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res 50: 1774–1778, 1990 Google Scholar
Conn G, Soderman DD, Schaeffer M-T, Wile M, Hatcher VB, Thomas KA: Purification of a glycoprotein vascular endothelial cell mitogen from a rat glioma-derived cell line. Proc Natl Acad Sci USA 87: 1323–1327, 1990 Google Scholar
Myoken Y, Kayada Y, Okamoto T, Kan M, Sato GH, Sato JD: Vascular endothelial cell growth factor (VEGF) produced by A-431 human epidermoid carcinoma cells and identification of VEGF membrane binding sites. Proc Natl Acad Sci USA 88: 5819–5823, 1991 Google Scholar
Leung DW, Cachianes G, Kuang W-J, Goeddel DV, Ferrara N: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246: 1306–1309, 1989 Google Scholar
Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, Connolly DT: Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309–1312, 1989 Google Scholar
Conn G, Bayne ML, Soderman DD, Kwok PW, Sullivan KA, Palisi TM, Hope DA, Thomas KA: Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. Proc Natl Acad Sci USA 87: 2628–2632, 1990 Google Scholar
Berse B, Brown LF, Van De Water L, Dvorak HF, Senger DR: Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol Biol Cell 3: 211–220, 1992 Google Scholar
Claffey KP, Wilkison WO, Spiegelman BM: Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways. J Biol Chem 267: 16317–16322, 1992 Google Scholar
Tischer E, Mitchell R, Hartman T, Silva M, G0spodarowicz D, Fiddes JC, Abraham JA: The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 266: 11947–11954, 1991 Google Scholar
Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N: Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem 267: 26031–26037, 1992 Google Scholar
Yeo T-K, Senger DR, Dvorak HF, Freter L, Yeo K-T: Glycosylation is essential for efficient secretion but not for permeability-enhancing activity of vascular permeability factor (vascular endothelial growth factor). BBRC 179: 1568–1575, 1991 Google Scholar
Peretz D, Gitay-Goren H, Safran M, Kimmel N, Gospodarowicz D, Neufeld G: Glycosylation of vascular endothelial growth factor is not required for its mitogenic activity. Biochem Biophys Res Commun 182: 1340–1347, 1992 Google Scholar
Sioussat TM, Dvorak HF, Brock TA, Senger DR: Inhibition of vascular permeability factor (vascular endothelial growth factor) with anti-peptide antibodies. Arch Biochem Biophys 301: 15–20. 1993 Google Scholar
Brock TA, Dvorak HF, Senger DR: Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells. Am J Pathol 138: 213–221, 1991 Google Scholar
Berridge MJ: Inositol trisphosphate and calcium signalling. Nature 361: 315–325, 1993 Google Scholar
de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT: The_fms_-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255: 989–991, 1992 Google Scholar
Terman BI, Carrion ME, Kovacs E, Rasmussen BA, Eddy RL, Shows TB: Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6: 1677–1683, 1991 Google Scholar
Terman BI, Dougher-Vermazen M, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, Böhlen P: Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun 187: 1579–1586, 1992 Google Scholar
Gitay-Goren H, Soker S, Vlodavsky I, Neufeld G: The binding of vascular endothelial growth factor to its receptor is dependent on cell surface-associated heparin-like molecules. J Biol Chem 267: 6093–6098, 1992 Google Scholar
Pepper MS, Ferrara N, Orci L, Montesano R: Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis_in vitro_. Biochem Biophys Res Commun 189: 824–831, 1992 Google Scholar
Wilting J, Christ B, Weich HA: The effects of growth factors on the day 13 chorioallantoic membrane (CAM): A study of VEGF165 and PDGF-BB. Anatomy and Embryology 186: 251–257, 1992 Google Scholar
Clauss M, Gerlach M, Gerlach H, Brett J, Wang F, Familletti PC, Pan Y-CE, Olander JV, Connolly DT, Stern D: Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J Exp Med 172: 1535–1545, 1990 Google Scholar
Dvorak HF: Abnormalities of hemostasis in malignancy. In: Colman RW, Hirsh J, Marder VJ, Salzman EW (ed) Hemostasis and Thrombosis. Basic Principles and Clinical Practice. 2ed. Philadelphia: J.B. Lippincott Company, 1987: 1143–1157 Google Scholar
Frost P, Hart I, Kerbel R (ed): The Hemostatic System in Malignancy. Kluwer Academic Publishers, Dordrecht, 1992, pp 223–431. Cancer and Metastasis Reviews; (vol 11) Google Scholar
Pepper MS, Ferrara N, Orci L, Montesano R: Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 181: 902–906, 1991 Google Scholar
Unemori EN, Ferrara N, Bauer EA, Amento EP: Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 153: 557–562, 1992 Google Scholar
Dvorak HF, Sioussat TM, Brown LF, Berse B, Nagy J, Sotrel A, Manseau EJ, Van De Water L, Senger DR: Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: Concentration in tumor blood vessels. J Exp Med 174: 1275–1278, 1991 Google Scholar
Dvorak HF, Dvorak AM, Manseau EJ, Wiberg L, Churchill WH: Fibrin gel investment associated with line 1 and line 10 solid tumor growth, angiogenesis, and fibroplasia in guinea pigs. Role of cellular immunity, myofibroblasts, microvascular damage, and infarction in line tumor regression. J Natl Cancer Inst 62: 1459–1472, 1979 Google Scholar
Plate KH, Breier G, Weich HA, Risau W: Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas_in vivo_. Nature 359: 845–848, 1992 Google Scholar
Ferrara N, Winer J, Burton T, Rowland A, Siegel M, Phillips HS, Terrell T, Keller GA, Levinson AD: Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage_in vivo_ to Chinese hamster ovary cells. J Clin Invest 91: 160–170, 1993 Google Scholar
Yayon A, Klagsbrun M, Esko JD, Leder P, Ornitz DM: Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 64: 841–848, 1991 Google Scholar
Andres JL, Stanley K, Chiefetz S, Massagué J: Membraneanchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-β. J Cell Biol 109: 3137–3145, 1989 Google Scholar
Cordon-Cardo C, Vlodavsky I, Haimovitz-Friedman A, Hicklin D, Fuks Z: Expression of basic fibroblast growth factor in normal human tissues. Lab Invest 63: 832–840, 1990 Google Scholar
Shweiki D, Itin A, Soffer D, Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: 843–845, 1992 Google Scholar
Koos RD, Olson CE: Hypoxia stimulates expression of the gene for vascular endothelial growth factor (VEGF), a putative angiogenic factor, by granulosa cells of the ovarian follicle, a site of angiogenesis [abstract]. J Cell Biol 115: 421a, 1991 Google Scholar
Berkman RA, Merrill MJ, Reinhold WC, Monacci WT, Saxena A, Clark WC, Robertson JT, Ali IU, Oldfield EH: Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. J Clin Invest 91: 153–159, 1993 Google Scholar
Kohn S, Nagy JA, Dvorak HF, Dvorak AM: Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels. Lab Invest 67: 596–607, 1992 Google Scholar
Palade GE: The microvascular endothelium revisited. In: Simionescu N, Simionescu M (ed) Endothelial Cell Biology in Health and Disease. New York: Plenum Press, 1988: 3–22 Google Scholar
Dvorak HF, Senger DR, Dvorak AM: Fibrin as a component of the tumor stroma: Origins and biological significance. Cancer Metastasis Rev 2: 41–73, 1983 Google Scholar
Folkman J: The role of angiogenesis in tumor growth. Seminars in Cancer Biology 3: 65–71, 1992 Google Scholar
Dvorak HF, Harvey VS, McDonagh J: Quantitation of fibrinogen influx and fibrin deposition and turnover in line 1 and line 10 guinea pig carcinomas. Cancer Res 44: 3348–3354, 1984 Google Scholar
Brown LF, Van De Water L, Harvey VS, Dvorak HF: Fibrinogen influx and accumulation of cross-linked fibrin in healing wounds and in tumor stroma. Am J Pathol 130: 455–465, 1988 Google Scholar
Brown LF, Asch B, Harvey VS, Buchinski B, Dvorak HF: Fibrinogen influx and accumulation of cross-linked fibrin in mouse carcinomas. Cancer Res 48: 1920–1925, 1988 Google Scholar
Costantini V, Zacharski LR, Memoli VA, Kisiel W, Kudryk BJ, Rousseau SM: Fibrinogen deposition without thrombin generation in primary human breast cancer tissue. Cancer Res 51: 349–353, 1991 Google Scholar
Hui KY, Haber E, Matsueda GR: Monoclonal antibodies to a synthetic fibrin-like peptide bind to human fibrin but not fibrinogen. Science 222: 1129–1132, 1983 Google Scholar
Van De Water L, Tracy PB, Aronson D, Mann KG, Dvorak HF: Tumor cell generation of thrombin via functional prothrombinase assembly. Cancer Res 45: 5521–5525, 1985 Google Scholar
Danø K, Andreasen PA, Grøndahl-Hansen J, Kristensen P, Nielsen LS, Skriver L: Plasminogen activators, tissue degradation, and cancer. In: Klein G, Weinhouse S (ed) Advances in Cancer Research. Orlando, FL: Academic Press, Inc., 1985: 139–266. (vol 44) Google Scholar
Kerbel RS, Greig R, Frost P (ed) The role of cellular proteases and their inhibitors in invasion and metastasis. Kluwer Academic Publishers, Dordrecht, 1990: 285–392. Cancer and Metastasis Reviews; (vol 9) Google Scholar
Dvorak HF, Senger DR, Dvorak AM, Harvey VS, McDonagh J: Regulation of extravascular coagulation by microvascular permeability. Science 227: 1059–1061, 1985 Google Scholar
Bissell MJ, Hall HG, Parry G: How does the extracellular matrix direct gene expression? J Theor Biol 99: 31–68, 1982 Google Scholar
Hynes RO, Lander AD: Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell 68: 303–322, 1992 Google Scholar
Hynes RO: Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 69: 11–25, 1992 Google Scholar
Damsky CH, Werb Z: Signal transduction by integrin receptors for extracellular matrix: Cooperative processing of extracellular information. Cur Opin Cell Biol 4: 772–781, 1992 Google Scholar
Dvorak HF, Harvey VS, Estrella P, Brown LF, McDonagh J, Dvorak AM: Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing. Lab Invest 57: 673–686, 1987 Google Scholar
Lanir N, Ciano PS, Van De Water L, McDonagh J, Dvorak AM, Dvorak HF: Macrophage migration in fibrin gel matrices. II. Effects of clotting factor XIII, fibronectin, and glycosaminoglycan content on cell migration. J Immunol 140: 2340–2349, 1988 Google Scholar
Brown LF, Lanir N, McDonagh J, Czarnecki K, Estrella P, Dvorak AM, Dvorak HF: Fibroblast migration in fibrin gel matrices. Am J Pathol 142: 273–283, 1993 Google Scholar
Yeo K-T, Sioussat T, Faix JD, Senger DR, Yeo T-K: Development of time-resolved immunofluorometric assay of vascular permeability factor. Clin Chem 38: 71–75, 1992 Google Scholar
Yeo K-T, Wang H, Nagy J, Senger D, Dvorak H, Yeo T-K: Vascular Permeability Factor levels in Line 1 and Line 10 ascites tumors and human fluids. J Cell Biol 115: 421a, 1991 Google Scholar
Nagy JA, Herzberg KT, Masse EM, Zientara GP, Dvorak HF: Exchange of macromolecules between plasma and peritoneal cavity in ascites tumor-bearing, normal, and serotonin-injected mice. Cancer Res 49: 5448–5458, 1989 Google Scholar
Nagy JA, Masse EM, Harvey-Bliss VS, Meyers MS, Sioussat TM, Senger DR, Dvorak HF: Immunochemical localization of vascular permeability factor (vascular endothelial growth factor) in ascites tumors: Distribution in peritoneal wall mi crovasculature. J Cell Biol 115: 264a, 1991 Google Scholar
Nagy JA, Herzberg KT, Dvorak JM, Dvorak HF: Pathogenesis of malignant ascites formation: Initiating events that lead to fluid accumulation. Cancer Res ([in press]): 000-000. 1993
Breier G, Albrecht U, Sterrer S, Risau W: Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 114: 521–532, 1992 Google Scholar
Maglione D, Guerriero V, Viglietto G, Delli-Bovi P, Persico MG: Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc Natl Acad Sci USA 88: 9267–9271, 1991 Google Scholar
Phillips HS, Hains J, Leung DW, Ferrara N: Vascular endothelial growth factor is expressed in rat corpus luteum. Endocrinology 127: 965–967, 1990 Google Scholar
Ravindranath N, Little-Ihrig L, Phillips HS, Ferrara N, Zeleznik AJ: Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary. Endocrinology 131: 254–260, 1992 Google Scholar
Brown LF, Yeo K-T, Berse B, Yeo T-K, Senger DR, Dvorak HF, Van De Water L: Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Experimental medicine 1992: 1375-9: 1375–1379 Google Scholar
Brown LF, Berse B, Tognazzi K, Manseau EJ, Van De Water L, Senger DR, Dvorak HF, Rosen S: Vascular permeability factor mRNA and protein expression in human kidney. Kidney International 42: 1457–1461, 1992 Google Scholar
Clark RA: Wound repair. Curr Opin Cell Biol 1: 1000–1008, 1989 Google Scholar
Breuing K, Eriksson E, Liu P, Miller DR: Healing of partial thickness porcine skin wounds in a liquid environment. J Surg Res 52: 50–58, 1992 Google Scholar
Dvorak HF, Galli SJ, Dvorak AM: Cellular and vascular manifestations of cell-mediated immunity. Hum Pathol 17: 122–137, 1986 Google Scholar
Yeo K-T, Wang H, Nagy J, Sioussat T, Ledbetter S, Hoogerverf A, Zhou Y, Masse E, Senger D, Dvorak H, Yeo T-K: Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions. Cancer Res 53: 1–7, 1993 Google Scholar