Quantitative cytoarchitectonics of the human cerebral cortex in schizophrenic dementia (original) (raw)
- 45 Accesses
- 27 Citations
- Explore all metrics
Summary
In this study an analysis is made of the quantitative changes in four areas (10, 4, 24, 17) of the cerebral cortex of patients with schizophrenia, in comparison with the normal cortex. In all areas the relation between neuron number, nuclear volume and depth was measured.
Most obvious is the finding of neuronal destruction (57%) which is minimal in the layers II and III (40%) and maximal in the layers IV and V and partially in VI (70%).
In combination with this cell-loss, the cortical thickness is diminished over about 20%. This means that also the number of other cortical elements must be reduced.
The cell-loss is random, but minimal in area 17. The nuclei are swollen except in area 17.
It is possible that this pathological-anatomical substrate is mere a characteristic of dementia, and not of schizophrenia. Further research will be directed to this problem.
Access this article
Subscribe and save
- Get 10 units per month
- Download Article/Chapter or eBook
- 1 Unit = 1 Article or 1 Chapter
- Cancel anytime Subscribe now
Buy Now
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Instant access to the full article PDF.
Similar content being viewed by others
References
- Bok, S. T.: Der Einfluß der in den Furchen und Windungen auftretenden Krümmungen der Großhirnrinde auf die Rindenarchitektur. Z. ges. Neurol. Psychiat.121, 682–750 (1929).
Google Scholar - —: A quantitative analysis of the structure of the cerebral cortex. Proc. Acad. Sci. (Amst.)35, 1–55 (1936).
Google Scholar - Bouman, K. H.: Die pathologische Anatomie des Zentralnervensystems bei Schizophrenie. Psychiat. neurol. Bl.32, 517–539 (1928).
Google Scholar - Cochran, W. G.: Some methods for strengthening the common_x_ 2tests. Biometrics10, 417–451 (1954).
Google Scholar - Colon, E. J.: Quantitative cytoarchitectonics of the human cerebral cortex. Psychiat. Neurol. Neurochir. (Amst.)74, 291–302 (1971).
Google Scholar - —, Smit, G. J.: Quantitative analysis of the cerebral cortex. II A method for analysing basal dendritic plexuses. Brain Res.22, 363–380 (1970).
Google Scholar - Fünfgeld, E.: Bemerkungen zur Histopathologie der Schizophrenie. Z. ges. Neurol. Psychiat158, 232–234 (1937).
Google Scholar - Glezer, I. I., Soukhoroukova, L. I.: Les particularités structurelles de la neurologie dans la schizophrenie à evolution periodique et continue. Zh. Neuropat. Psikhiat.66, 1529–1537 (1966).
Google Scholar - Kirschbaum, W. R., Heilbrung, G.: Biopsies of brain schizophrenic patients and experimental animals. Arch. Neurol. Psychiat. (Chic.)51, 155 (1944).
Google Scholar - Maximow, A., Bloom, W.: A textbook of histology, pp. 224–225. London: W. Saunders Comp. 1958.
Google Scholar - Miskolczy, D.: Die örtliche Verteilung der Gehirnveränderungen bei Schizophrenie. Z. ges. Neurol. Psychiat.158, 203–208 (1937).
Google Scholar - Rebhan, Ilse: Der Grauzellkoeffizient der menschlichen Hirnrinde. Berechnungen nach dem Zahlenmaterial v. Economos. Acta anat. (Basel)27, 361–386 (1956).
Google Scholar - Scheller, H.: Morphologische Aspekte bei schizoformen Psychosen. Arzneimittel-Forsch.16, 279–281 (1966).
Google Scholar - Tourney, G.: History of biological psychiatry in America. Amer. J. Psychiat.126, 29–42 (1969).
Google Scholar - Vogt, C., Vogt, O.: Alterations anatomique de la schizophrenie. 1st. Int. Congr. Neuropath.1, 5–15 (1952).
Google Scholar - Vogt, M.: The concentration of sympathine in different parts of the central nervous system under normal conditions and after administration of drugs. J. Physiol. (Lond.)123, 451 (1954).
Google Scholar - Wildi, E., Linder, A., Costoules, G.: Schizophrenie et involution cérébrale sénile. Psychiat. et Neurol. (Basel)154, 1–26 (1967).
Google Scholar - Yates, F.: The analysis of contingency tables with groupings based on quantitative characters. Biometrika35, 176–181 (1948).
Google Scholar - Zaiko, Y. V.: Les alterations morphologiques des cerveau dans la schizophrenie compliquée de maladie hypertonique. Zh. Nervopat. Psikhiat. Korsakov66, 1692–1698 (1966).
Google Scholar
Author information
Authors and Affiliations
- Psychopathologic and Neurophysiologic Laboratory of the University of Nijmegen, Berg en Dalseweg 105, Nijmegen, The Netherlands
E. J. Colon - Radboud Ziekenhuis, University of Nijmegen, The Netherlands
E. J. Colon
Authors
- E. J. Colon
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Colon, E.J. Quantitative cytoarchitectonics of the human cerebral cortex in schizophrenic dementia.Acta Neuropathol 20, 1–10 (1972). https://doi.org/10.1007/BF00687897
- Received: 24 March 1971
- Issue Date: March 1972
- DOI: https://doi.org/10.1007/BF00687897