Abnormal fibrils from scrapie-infected brain (original) (raw)
Summary
Abnormal fibrillary structures, designated “scrapie-associated fibrils” (SAF), have been observed using negative stain techniques in subfractions of brains from scrapie-affected animals. SAF have been observed in all combinations of strain of scrapie agent and strain or species of host examined, regardless of their histopathology, in particular the presence or absence of amyloid plaques. SAF consist either of two or four filaments. They are morphologically dissimilar to the normal brain fibrils — microtubules, neurofilaments, glial filaments, and F actin. However, SAF do bear a resemblance to amyloid.
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Authors and Affiliations
- New York State Institute for Basic Research in Mental Retardation, 1050 Forest Hill Road, 10314, Staten Island, NY, USA
P. A. Merz, R. A. Somerville, H. M. Wisniewski & K. Iqbal
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- P. A. Merz
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Merz, P.A., Somerville, R.A., Wisniewski, H.M. et al. Abnormal fibrils from scrapie-infected brain.Acta Neuropathol 54, 63–74 (1981). https://doi.org/10.1007/BF00691333
- Received: 24 October 1980
- Accepted: 28 November 1980
- Issue Date: March 1981
- DOI: https://doi.org/10.1007/BF00691333