An altered electroretinogram transient associated with an unusual jump response in a mutant ofDrosophila (original) (raw)
Summary
- Mutations at the_stoned_ locus of_Drosophila melanogaster_ produce a reversible temperature-sensitive debilitation. At permissive temperatures they also exhibit an unusual jump response to a light-off stimulus.
- An increase in the amplitude of the off-transient of the electroretinogram (ERG) is associated with this abnormal jump. Both the jump response and the increased amplitude of the off-transient are shown to be dependent on the duration of the light pulse prior to the light-off stimulus.
- In_stoned_ flies which are light adapted, the jump response, as measured by recording from the indirect flight muscles, is seen to habituate with increasing light-off frequency. This habituation corresponds to the decrease in the amplitude of the off-transient that also occurs with high-frequency stimulation.
- Another visual mutant_tan_, removes the off and on-transients of the ERG.
- The combining of the_stoned_ mutation with_tan_ in the_tan, stoned_ double mutant results in the loss of the jump behavior as well as the partial restoration of the off-transient to an otherwise_tan_-like ERG. The relationship between the increase in the amplitude of the off-transient in_stoned_ flies and the eliciting of the jump response is discussed.
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References
- Alawi, A. A., and Pak, W. L. (1971). On-transient of the insect electroretinogram. Its cellular origin.Science 1721055–1057.
Google Scholar - Cosens, D., and Manning, A. (1969). Abnormal electroretinogram from a_Drosophila_ mutant.Nature 224285–287.
Google Scholar - Eichenbaum, D. M., and Goldsmith, T. H. (1968). Properties of insect photoreceptors lacking synapses.J. Exp. Zool. 16915–32.
Google Scholar - Greenspan, R. J. (1980). Mutations of choline acetyltransferase and associated neural defects in_Drosophila melanogaster_.J. Comp. Physiol. 13783–92.
Google Scholar - Greenspan, R. J., Finn, J. A., and Hall, J. C. (1980). Acetylcholinesterase mutants in_Drosophila_ and their effects on the structure and function of the central nervous system.J. Comp. Neurol. 189741–774.
Google Scholar - Grigliatti, T. A., Hall, L., Rosenbluth, R., and Suzuki, D. T. (1973). Temperature-sensitive mutations in_Drosophila melanogaster._ XIV. A selection of immobile adults.Mol. Gen. Genet. 120107–114.
Google Scholar - Hotta, Y., and Benzer, S. (1969). Abnormal electroretinograms in visual mutants of_Drosophila_.Nature 222354–356.
Google Scholar - Kaplan, W. D. (1972). Genetic and behavioral studies of_Drosophila_ neurological mutants. In_The Biology of Behavior_ (J. A. Kiger, Ed.), Oregon State University Press, Corvallis, pp. 133–157.
Google Scholar - King, D. G. (1977). An interneuron in_Drosophila_ synapses within a peripheral nerve onto the dorsal longitudinal muscle motor neurons.Neurosci. Abstr. 3180.
Google Scholar - Levine, J. D. (1974). Giant neuron input in mutant and wild-type_Drosophila_.J. Comp. Physiol. 93265–285.
Google Scholar - Pak, W. L. (1975). Mutations affecting the vision of_Drosophila melanogaster_. In_Handbook of Genetics, Vol. 3_ (R. C. King, Ed.), Plenum Press, New York, pp. 703–733.
Google Scholar - Pak, W. L., Grossfield, J., and White, N. V. (1969). Non-phototactic mutants in a study of vision in_Drosophila_.Nature 222351–354.
Google Scholar - Salkoff, L. B., and Kelly, L. E. (1978). Temperature induced seizure and frequency dependent neuromuscular block in a_ts_ mutant of_Drosophila_.Nature 273156–158.
Google Scholar
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- Leonard E. Kelly
Present address: Department of Genetics, University of Melbourne, 3052, Parkville, Victoria, Australia
Authors and Affiliations
- Department of Genetics, University of California, Berkeley, 94720, Berkeley, California, USA
Leonard E. Kelly
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- Leonard E. Kelly
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Kelly, L.E. An altered electroretinogram transient associated with an unusual jump response in a mutant of_Drosophila_.Cell Mol Neurobiol 3, 143–149 (1983). https://doi.org/10.1007/BF00735278
- Received: 01 February 1982
- Revised: 01 April 1983
- Accepted: 06 April 1983
- Issue Date: June 1983
- DOI: https://doi.org/10.1007/BF00735278