Permeability to inhibitors of protein synthesis in virus infected cells (original) (raw)

Abstract

Infection of HeLa cells with different viruses induces permeabilization of the cell membrane to protein toxins such as α-sarcin. This phenomenon occurs with HeLa, KB, BHK-21 and L929 cells and EMC, SFV, VSV and Polio virus and is dependent on the ability of the virus to infect the cells. Inhibitors of endocytosis and lysosomotropic agents do not affect this process. Cells become sealed to the toxin approximately four hours after the infection. Sulfhydryl reagents impair cellular permeabilization to α-sarcin.

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Authors and Affiliations

1. Departamento de Microbiología, Centro de Biología Molecular, Universidad Autónoma de Madrid, Canto Blanco, 34, Madrid, Spain
   C. Fernández-Puentes

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1. C. Fernández-Puentes
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Fernández-Puentes, C. Permeability to inhibitors of protein synthesis in virus infected cells.Mol Biol Rep 10, 65–68 (1984). https://doi.org/10.1007/BF00776975

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• Received: 05 December 1983
• Issue Date: December 1984
• DOI: https://doi.org/10.1007/BF00776975

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