Apoptosis of human BEL-7402 hepatocellular carcinoma cells released by antisense H-ras DNA-in vitro and in vivo studies (original) (raw)
References
Ansari B, Coates PJ, Greenstein BD, Hall PA (1993) In situ endlabelling detects DNA strand breaks in apoptosis and other physiological and pathological states. J Pathol 170:1–8 PubMed Google Scholar
Arends MJ, McGregor AH, Toft NJ, Brown EJH, Wyllie AH (1993) Susceptibility to apoptosis is differentially regulated by c-myc and Ha-ras oncogenes and is associated with endonuclease availability. Br J Cancer 68:1127–1133 PubMed Google Scholar
Arends MJ, McGregor AH, Wyllie AH (1994) Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed_myc, ras_, and_HPV_ oncogenes. Am J Pathol 144:1045–1057 PubMed Google Scholar
Bernards A (1995) Neurofibromatosis type 1 and Ras-mediated signalling: filling in the gaps. Biochim biophys Acta 1242:43–59 PubMed Google Scholar
Bissonnette RP, Echeverri F, Mahboubi A, Green DR (1992) Apoptotic cell death induced by c-myc is inhibited by_bcl-2_. Nature 359:552–554 PubMed Google Scholar
Bos JL (1988) The_ras_ gene family and human carcinogenesis. Mutat Res 195:255–271 PubMed Google Scholar
Bos JL (1989)ras oncogenes in human cancer: a review. Cancer Res 49:4682–4689 PubMed Google Scholar
Bos JL (1995) P21Ras: an oncoprotein functioning in growth factor-induced signal transduction. Eur J Cancer 31A:1051–1054 Google Scholar
Burt RK, Garfield S, John K, Thorgeirsson SS (1988) Transformation of rat liver epithelial cells with v-Ha-ras or v-raf causes expression of MDR-1, glutathione-_S_-transferase-P and increased resistance to cytotoxic chemicals. Carcinogenesis 9:2329–2332 PubMed Google Scholar
Calabretta B, Skorski T, Szczylik C, Zon G (1993) Prospects for gene-directed therapy with antisense oligodeoxynucleotides. Cancer Treat Rev 19:169–179 PubMed Google Scholar
Carson DN, Riboro JM (1993) Apoptosis and disease. Lancet 341:1251–1254 PubMed Google Scholar
Carter G, Lemoine NR (1993) Antisense technology for cancer therapy: does it make sense? Br J Cancer 67:869–876 PubMed Google Scholar
Charlotte F, Lermine A, Martin N, Geleyn Y, Nollet M, Gaulard P, Zafrani ES (1994) Immunohistochemical detection of_bcl-2_ protein in normal and pathological human liver. Am J Pathol 144:460–465 PubMed Google Scholar
Chen CH, Zhang J, Ling CC (1994) Transfected c-myc and c-Ha-ras modulate radiation-induced apoptosis in rat embryo cells. Radiat Res 139:307–315 PubMed Google Scholar
Chen FH, Xia QJ, Li YX (1991) RNA-RNA in situ hybridization for study of expression of c-myc and H-_ras_-1 genes in human primary liver cell carcinoma. Tumor (Shanghai) 11:193–194 Google Scholar
Cheng RM, Chu TH, Yeh HJ, et al. (1979) Establishment of three human hepatocellular carcinoma cell lines cultured in vitro and their characteristics. China Sci 12:1225–1233 Google Scholar
Chin KV, Ueda K, Pastan I, Gottesman MM (1992) Modulation of activity of the promotor of the human_MDR1_ gene by_ras_ and p53. Science 255:459–462 PubMed Google Scholar
Clarke AR, Purdie CA, Harrison DJ, Bird CC, Hooper ML, Wyllie AH (1993) Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362:849–852 PubMed Google Scholar
Collins MKL, Revas AL (1993) The control of apoptosis in mammalian cells. Trends Biol Sci 18:307–309 Google Scholar
Compton MM (1992) A biochemical hallmark of apoptosis: internucleosomal degradation of the genome. Cancer Metastasis Rev 11:105–119 PubMed Google Scholar
Crook AT (1993) Progress toward oligonuleotide therapeutics pharmacodynamic properties. FASEB J 7:533–539 PubMed Google Scholar
Eastman A (1995) Survival factors, intracellular signal transduction, and the activation of endonucleases in apoptosis. Semin Cancer Biol 6:45–53 PubMed Google Scholar
Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119–128 PubMed Google Scholar
Fanidi A, Harrington EA, Aevan GI (1992) Cooperative interaction between c-myc and_bcl-2_ proto-oncogenes. Nature 359:554–556 PubMed Google Scholar
Fernandez A, Fosdick LJ, Marin MC, Diaz C, McDonnell TJ, Ananthaswamy HN, McConkey DJ (1995) Differential regulation of endogenous endonuclease activation in isolated murine fibroblast nuclei by ras and bcl-2. Oncogene 10: 769–774 PubMed Google Scholar
Fernandez-Sarabia MJ, Bishoff JR (1994)bcl-2 associated with the_ras_-related protein R-ras p23. Nature 366:274–275 Google Scholar
Frisch SM, Francis H (1994) Disruption of epithelial cell-matrix interaction induces apoptosis. J Cell Biol 124:619–626 PubMed Google Scholar
Gray GD, Hernandez OM, Hebel D, Root M, Pow-Sang JM, Wickstrom E (1993) Antisense DNA inhibition of tumor growth induced by c-Ha-ras oncogene in nude mice. Cancer Res 53:577–580 PubMed Google Scholar
Greig RG, Koestler TP, Trainer DL, Corwin SP, Miles L, Kline T, Sweet R, Yokoyama S, Poste G (1985) Tumorigenic and metastatic properties of normal and_ras_-transfected NIH 3T3 cells. Proc Natl Acad Sci USA 82:3698–3701 PubMed Google Scholar
Gulbins E, Bissonnette R, Mahboubi A, Martin S, Nishioka W, Brunner T, Baier G, Baier-Bitterlich G, Byrd C, Lang F (1995) Fas-induced apoptosis is mediated via a ceramide-initiates Ras signaling pathway. Immunity 2:341–351 PubMed Google Scholar
Harrington EA, Fanidi A, Evan GI (1994) Oncogenes and cell death. Curr Opin Genet Dev 4:120–129 PubMed Google Scholar
Helene C (1991) Rational design of sequence-specific oncogene inhibitors based on antisense and antigene oligonucleotides. Eur J Cancer 27:1460–1471 Google Scholar
Hockenbery DM, Oltvai ZN, Yin XM, Milliamanb CL, Korsmeyer SJ (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241–251 PubMed Google Scholar
Hofmann M, Rudy W, Gunthert U, Zimmer SG, Zawadzki V, Zoller M, Lichtner RB, Herrlich P, Ponta H (1993) A link between_ras_ and metastatic behavior of tumor cells:ras induces CD44 promoter activity and leads to low-level expression of metastasis-specific variants of CD44 in CREF cells. Cancer Res 53:1516–1521 PubMed Google Scholar
Hu QJ, Klippel A, Muslin AJ, Fantl WJ, Williams LT (1995) Rasdependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science 268:100–102 PubMed Google Scholar
Huschtscha LI, Jeitner TM, Andersson CE, Bartier WA, Tattersall MHN (1994) Identification of apoptotic and necrotic human leukemic cells by flow cytometry. Exp Cell Res 212:161–165 PubMed Google Scholar
Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA (1992) Effects of an Rb mutation in the mouse. Nature 259:295–300 Google Scholar
Kerbel RS, Kobayashi H, Graham CH (1994) Intrinsic or acquired drug resistance and metastasis: are they linked phenotypes? J Cell Biochem 56:37–47 PubMed Google Scholar
Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239–245 PubMed Google Scholar
Khosravi-Far R, Der CJ (1994) The Ras signal transduction pathway. Cancer Metastasis Rev 13:67–89 PubMed Google Scholar
Laio Y, Tang ZY, Liu KD (1994) Protooncogenes and apoptosis. Chin J Cancer Biother 1:70–74 Google Scholar
Lee EY, Chang CY, Hu N, Wang YCJ, Lai CC, Herrup K, Lee WH (1992) Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 259:288–294 Google Scholar
Lin HJ, Eviner V, Prendergast GC, White E (1995) Activated H-ras rescues E1A-induced apoptosis and cooperate with E1A to overcome p53-dependent growth arrest. Mol Cell Biol 15:4536–4544 PubMed Google Scholar
Lowe SW, Ruley HE, Jacks T, Housman DE (1993) p53-dependent apoptosis modulates the cytotoxicity of anti-cancer agents. Cell 74:957–967 PubMed Google Scholar
Malcomson RD, Oren M, Wyllie AH, Harrison DJ (1995) P53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs. Br J Cancer 72:952–957 PubMed Google Scholar
Marshall MS (1995) Ras target proteins in eukaryotic cells. FASEB J 9:1311–1318 PubMed Google Scholar
Martin SJ, Green DR (1995) Apoptosis and cancer: the failure of controls on cell death and cell survival. Crit Rev Oncol Hematol 18:137–153 PubMed Google Scholar
McConkey DJ, Fernandez A, Trent J, Ananthaswamy HN (1995) Oncogene regulation of endonuclease activation in apoptosis. Cancer Lett 94:9–16 PubMed Google Scholar
Metelev V, Agrawal S (1992) Ion-exchange high-performance liquid chromatography analysis of oligodeoxyribonucleotide phosphorothioates. Anal Biochem 200:342–346 PubMed Google Scholar
Milligan JF, Matteucci MD, Martin JC (1993) Current concepts in antisense drug design. J Med Chem 36:1923–1937 PubMed Google Scholar
Mirabelli CK, Crooke ST (1993) Antisense oligonucleotides in the context of modern molecular drug discovery and development. In: Antisense research and applications. Crooke ST, Bernard L (eds) CRC, Boca Raton, Fla, pp 7–35 Google Scholar
Mitsuhashi BY, Filmus BJ, Shirasawa S, Sasazuki T, Kerbel RS (1995) Mutant_ras_ oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumour angiogenesis. Cancer Res 55:4575–4580 PubMed Google Scholar
Moore J, Boswell S, Hoffman R, Burgess G, Hromas R (1993) Mutation H-ras over-expression inhibits a random apoptotic nuclease in myeloid leukemia cells. Leuk Res 17:703–709 PubMed Google Scholar
Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139:271–279 PubMed Google Scholar
Nooter K, Boersma AWM, Oostrum RG, Burger H, Jochemsen A, Stoter G (1995) Constitutive expression of the c-H-ras oncogene inhibit doxorubicin-induced apoptosis and promotes cell survival in a rhabdomyosarcoma cell line. Br J Cancer 71:556–561 PubMed Google Scholar
Oberhammer FA, Pavelka M, Shama S, Tiefenbacher R, Purchio AF, Bursch W, Schulte-Hermann R (1992) Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc Natl Acad Sci USA 89:5408–5412 PubMed Google Scholar
Oren M (1992) The involvement of oncogenes and tumor suppressor genes in the control of apoptosis. Cancer Metastasis Rev 11:141–148 PubMed Google Scholar
Packham G, Cleveland JL (1995) C-myc and apoptosis. Biochim Biophys Acta 1242:11–28 PubMed Google Scholar
Patel T, Gores GJ (1995) Apoptosis and hepatobiliary disease. Hepatology 21:1725–1741 PubMed Google Scholar
Reddy EP (1983) Nucleotide sequence analysis of the T24 human bladder carcinoma oncogene. Science 220:1061–1063 PubMed Google Scholar
Reed JC (1994) Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1–6 PubMed Google Scholar
Rose JK, Gallione CJ (1981) Nucleotide sequences of the mRNAs encoding the vesicular stomatosis G and M proteins determined from cDNA clones containing the complete coding regions. J Virol 39:519–528 PubMed Google Scholar
Sakai N, Ogiso Y, Fujita H, Watari H, Koike T, Kuzumaki N (1994) Induction of apoptosis by a dominant negative H-ras mutant (116Y) in K562 cells. Exp Cell Res 215:131–136 PubMed Google Scholar
Scanlon KJ, Ohta Y, Ishida H, Kijima H, Ohkawa T, Kaminski A, Tsai J, Horng G, Kashani-Sabet MK (1995) Oligonucleotidemediated modulation of mammalian gene expression. FASEB J 9:1288–1296 PubMed Google Scholar
Schwartz LM, Osborne BA (1993) Programmed cell death, apoptosis and killer genes. Immunol Today 14:582–590 PubMed Google Scholar
Shack S, Chen LC, Miller AC, Danes R, Amid D (1995) Increased susceptibility of_ras_-transformed cells to phenylacetate is associated with inhibition of p21 ras isoprenylation and phenotypic reversion. Int J Cancer 63:124–129 PubMed Google Scholar
Shaw P, Bovey R, Tardy S, Sahli R, Sordt B, Costa J (1992) Induction of apoptosis by wild-type p53 in a colon tumor-derived cell line. Proc Natl Acad Sci USA 89:4495–4499 PubMed Google Scholar
Spaargaren M, Martin GA, McCorcomick F, Fernandez-Sarabia MJ, Bischoff JR (1994) The_ras_-related protein R-ras interacts directly with Raf-1 in a GTP-dependent manner. Biochem J 300:303–307 PubMed Google Scholar
Spaargaren M, Bischoff JR, McCormick F (1995) Signal transduction by Ras-like GTPases: a potential target for anticancer drugs. Gene Expr 4:345–356 PubMed Google Scholar
Stein CA, Cheng YC (1993) Antisense olignucleotides as therapeutic agents-is the bullet really magical? Science 261:1004–1012 PubMed Google Scholar
Steller H (1995) Mechanisms and genes of cellular suicide. Science 267:1445–1449 PubMed Google Scholar
Stewart BW (1994) Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. J Natl Cancer Inst 17:1286–1296 Google Scholar
Tabor E (1994) Tumor suppressor genes, growth factor genes, and oncogenes in hepatitis B virus-associated hepatocellular carcinoma. J Med Virol 42:357–365 PubMed Google Scholar
Tang ZY (1996) Small hepatocellular carcinoma: past, present and future. Chin Med J 109:21–24 PubMed Google Scholar
Thompson CB (1995) Apoptosis in pathogenesis and treatment of disease. Science 267:1456–1462 PubMed Google Scholar
Wagner RW (1994) Gene inhibition using antisense oligodeoxynucleotides. Nature 372:333–335 PubMed Google Scholar
Wickstrom EL, Bacon TA, Gonzalez A, Freeman DL, Lyman GH, Wicksrom E (1988) Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by antisense pentadecadeoxynucleotide targeted against c-myc mRNA. Proc Natl Acad Sci USA 85:1028–1032 PubMed Google Scholar
Williams GT, Smith CA (1993) Molecular regulation of apoptosis: genetic controls on cell death. Cell 74:777–779 PubMed Google Scholar
Wong Y, Lin ZY (1996) Preliminary study on the relationship between the H-ras oncogene and the metastasis or invasion of hepatocellular carcinoma. In: Tang ZY, Ye SL (eds) Recent progress in liver cancer and hepatitis. Beijing International Academic Publishers, Beijing, p 80 Google Scholar
Wood AC, Waters CM, Garner A, Hickman JA (1994) Changes in c-myc expression and kinetics of dexamethasone-induced programmed cell death (apoptosis) in human lymphoid leukaemia cells. Br J Cancer 69:663–669 PubMed Google Scholar
Wyllie AH (1992) Apoptosis and regulation of cell numbers in normal and neoplastic tissues: an overview. Cancer Metastasis Rev 11:95–103 PubMed Google Scholar
Wyllie AH, Rose KA, Morris RG, Steel CM, Foster E, Spandidos DA (1987) Rodent fibroblast tumors expressing human_myc_ and_ras_ genes: growth, metastasis and endogenous oncogene expression. Br J Cancer 56:251–259 PubMed Google Scholar
Zon G, Geiser TG (1991) Phosphorothioate oligonucleotides: chemistry, purification, analysis, scale-up and future direction. Anticancer Drug Des 6:539–568 PubMed Google Scholar