Influence of the antimicrotubule agent, mebendazole, on the secretory activity of intestinal cells ofAscaridia galli (original) (raw)

Summary

The anthelmintic compound mebendazole caused the disappearance of microtubules in the intestinal cells of_Ascaridia galli_. Electron microscopy revealed that soon after the microtubules disappeared there was an accumulation of secretory vesicles near the golgi areas. subsequently many of these vesicles aggregated forming dense large vesicles near the terminal web of the intestinal cells. This provides further evidence for the involvement of microtubules in the secretion of products from eukaryotic cells. It seems likely that inhibition of microtubule directed secretory functions in various cell types is an important function in the anthelmintic activity of the benzimidazole carbamates.

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Author notes

1. Charlotte Atkinson
   Present address: Department of Applied Zoology, University College of North Wales, Bangor, Wales

Authors and Affiliations

1. Biological Laboratory, University of Kent, CT2 7NJ, Canterbury, Kent, England
   Charlotte Atkinson, R. J. Newsam & K. Gull

Authors

1. Charlotte Atkinson
2. R. J. Newsam
3. K. Gull

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Atkinson, C., Newsam, R.J. & Gull, K. Influence of the antimicrotubule agent, mebendazole, on the secretory activity of intestinal cells of_Ascaridia galli_.Protoplasma 105, 69–76 (1980). https://doi.org/10.1007/BF01279850

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• Received: 19 June 1980
• Accepted: 07 July 1980
• Issue date: March 1980
• DOI: https://doi.org/10.1007/BF01279850

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