Non-A, non-B hepatitis: visualization of virus-like particles from chimpanzee and human sera (original) (raw)

Summary

Virus-like particles (VLP), morphologically similar to togavirus particles, were detected in the sera of chimpanzees and humans with chronic non-A, non-B (NANB) hepatitis. Particles resembling the virus were also found in the cytoplasm of hepatocytes obtained from NANB hepatits infected chimpanzees. Furthermore, two chimpanzees inoculated with materials containing the VLP developed NANB hepatitis. These results strongly suggest that the VLP may be closely associated with the agent of NANB hepatitis.

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Authors and Affiliations

  1. Department of Pathology, National Institute of Health, Tokyo, Japan
    Kenji Abe & Takeshi Kurata
  2. Department of Pathology, Nihon University School of Medicine, Tokyo, Japan
    Toshio Shikata

Authors

  1. Kenji Abe
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  2. Takeshi Kurata
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  3. Toshio Shikata
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Abe, K., Kurata, T. & Shikata, T. Non-A, non-B hepatitis: visualization of virus-like particles from chimpanzee and human sera.Archives of Virology 104, 351–355 (1989). https://doi.org/10.1007/BF01315557

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