A mutation inzap-70 protein tyrosine kinase results in a selective immunodeficiency (original) (raw)

References

  1. Roifman CM, Hummel D, Martinez-Valdez H, Thorner P, Doherty PJ, Pan S, Cohen F, Cohen A: Depletion of CD8+ cells in human thymic medulla results in selective immune deficiency. J Exp Med 170:2177–2182, 1989
    PubMed Google Scholar
  2. Samelson LE, Patel MD, Weissman AM, Harford JB, Klausner RD: Association of the_fyn_ antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell 46:1083–1090, 1986
    PubMed Google Scholar
  3. June CH, Fletcher MC, Ledbetter JA, Samelson LE: Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation. J Immunol 144:1591–1599, 1990
    PubMed Google Scholar
  4. Appelby MW, Gross JA, Cook MP, Levine SD, Qian X, Perlmutter RM: Defective T-cell receptor signaling in mice lacking the thymic isoform of p59_fyn_. Cell 70:751–763, 1992
    PubMed Google Scholar
  5. Stein PL, Lee H-M, Rich S, Soriano P: p59_fyn_ mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 70:741–750, 1992
    PubMed Google Scholar
  6. Veillette A, Zuiniga-Pflucker JC, Bolen JB, Kruisbeek AM: Engagement of CD4 and CD8 expressed on immature thymocytes induced activation of intracellular tyrosine phosphorylation pathways. J Exp Med 170:1671–1689, 1989
    PubMed Google Scholar
  7. Glaichenhaus N, Shastri N, Littman D, Turner J: Requirement for association of p56l_ck_ with CD4 antigen-specific signal transduction in T cells. Cell 64:511–520, 1991
    PubMed Google Scholar
  8. Straus DB, Weiss A: Genetic evidence for the involvement of the_lck_ tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70:585–593, 1992
    PubMed Google Scholar
  9. Molina TJ, Kishihara K, Siderovski DP, Ewijk W, van Narendran A, Timms E, Wakeham A, Paige CJ, Hartmann K-UU, Veillette A, Davidson D, Mak TW: Profound block in thymocyte development in mice lacking p56lck. Nature 357:161–164, 1992
    PubMed Google Scholar
  10. Chan AC, Irving B, Fraser JD, Weiss A: The TCR_ζ_ chain associates with a tyrosine kinase and upon TCR stimulation associates with_zap_-70, a 70K Mr tyrosine phosphoprotein. Proc Natl Acad Sci USA 88:9166–9170, 1991
    PubMed Google Scholar
  11. Smith KA: Interleukin 2. Annu Rev Immunol 2:319–333, 1984
    PubMed Google Scholar
  12. Greene WC, Leonard WJ: The human interleukin 2 receptor. Annu Rev Immunol 14:69–95, 1986
    Google Scholar
  13. Mills GB, Benedict S, Mellors A, Grinstein S, Gelfand EW: Transmembrane signaling by interleukin 2.In Interleukin 2, K Smith (ed). San Diego, CA, Academic Press, 1986, pp 113–135
    Google Scholar
  14. Orita M, Suzuki Y, Sekya T, Hayoski K: Rapid and sensitive detection of point mutations and DNA polymorphism using the polymerase chain reaction. Genomics 5:874–879, 1989
    PubMed Google Scholar
  15. Hanks SK, Quinn AM, Hunter T: The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains. Science 241:42–52, 1988
    PubMed Google Scholar
  16. Seong RH, Chamberlain JW, Parnes JR: Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Nature 356:718–720, 1992
    PubMed Google Scholar
  17. Takahama Y, Singer A: Post-transcriptional regulation of early T cell development by T-cell receptor signals. Science 258:1456–1462, 1992
    PubMed Google Scholar
  18. Gilliland LK, Teh HS, Uckun FM, Norris NA, Teh SJ, Schieven GL, Ledbetter JA: CD4 and CD8 are positive regulators of T-cell receptor signal transduction in early T cell differentiation. J Immunol 146:1759–1765, 1991
    PubMed Google Scholar
  19. Nakayama T, Singer A, Hsi ED, Samelson LE: Intrathymic signaling in immature CD+CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain. Nature 341:651–654, 1989
    PubMed Google Scholar
  20. Doherty PJ, Roifman CM, Pan SH, Cymerman U, Ho SW, Thompson E, Kamel RS, Cohen A: Expression of the human T-cell receptor V beta repertoire. Mol Immunol 28:607–612, 1991
    PubMed Google Scholar
  21. Bosma GC, Fried M, Custer RP, Carroll A, Gibson DM, Bosma MJ: Evidence of functional lymphocytes in some (leaky) SCID mice. J Exp Med 167:1016–1033, 1988
    PubMed Google Scholar
  22. Perlmutter RM, Levin SD, Appleby MW, Anderson SJ, AlberolaIla J: Regulation of lymphocyte function by protein phosphorylation. Annu Rev Immunol 11:451–499, 1993
    PubMed Google Scholar
  23. Chan IT, Limmer A, Louie MC, Bullock ED, Fung LWP, Mak TW, Loh DY: Thymic selection of cytotoxic T cells independent of CD8 alpha-lck association. Science 261:1581–1584, 1993
    PubMed Google Scholar
  24. Weiss A: T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases. Cell 73:209–212, 1993
    PubMed Google Scholar
  25. Samelson LE, Phillips AF, Luong ET, Klausner RD: Association of the_fyn_ protein-tyrosine kinase with the T-cell antigen receptor. Proc Natl Acad Sci USA 87:4358–4362, 1990
    PubMed Google Scholar
  26. Gassmann M, Guttinger M, Amrein KE, Burn P: Protein tyrosine kinase p59_fyn_ is associated with the T cell receptor-CD3 complex in functional human lymphocytes. Eur J Immunol 22:283–286, 1992
    PubMed Google Scholar
  27. Cooke MP, Abraham KM, Forbush KA, Perlmutter RM: Regulation of T-cell receptor signaling by the_src_ family protein-tyrosine kinase (p59_fyn_). Cell 5:281–291, 1991
    Google Scholar
  28. Davidson D, Chow LM, Fournel M, Veillette A: Differential regulation of T-cell antigen responsiveness by isoforms of the_src_-related tyrosine protein kinase p59_fyn_. J Exp Med 175:1483–1492, 1992
    PubMed Google Scholar
  29. Rudd C: CD4, CD8, and the TCR-CD3 complex: A novel class of protein-tyrosine kinase receptor. Immunol Today 11:400–406, 1990
    PubMed Google Scholar
  30. Abraham N, Miceli MC, Parnes JR, Veillette A: Enhancement of T cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56_lck_. Nature 350:62–66, 1991
    PubMed Google Scholar
  31. Kamitz L, Sutor SL, Torigoe T, Reed JC, Bell MP, McKean DJ, Leibson PJ, Abraham RT: Effects of p56_lck_ deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line. Mol Cell Biol 12:4521–4530, 1992
    PubMed Google Scholar
  32. Arpaia E, Shahar M, Dadi H, Cohen A, Roifman CM: Defective T-cell receptor signaling and CD8+ thymic selection in humans lacking_zap_-70 kinase. Cell 76:947–958, 1994
    PubMed Google Scholar
  33. Roifman CM, Mills GB, Cheung RK, Gelfand EW: Mitogenic response of human thymocytes: Identification of functional Ca++-dependent and independent signals. Clin Exp Immunol 66:139–149, 1986
    PubMed Google Scholar
  34. Fowlkes BJ, Pardoll DM: Molecular and cellular events of T cell development. Adv Immunol 44:207–264, 1989
    PubMed Google Scholar
  35. Bill J, Palmer B: Positive selection of CD4+ T cells mediated by MHC class II-bearing stromal cell in the thymic cortex. Nature 341:649–651, 1989
    PubMed Google Scholar
  36. Kisielow P, Teh HS, Bluthmann H, von Boehmer H: Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335:730–733, 1988
    PubMed Google Scholar
  37. Marusic-Galesic S, Stephany DA, Longo DL, Kruisbeek AM: Development of CD4−CD8+ cytotoxic T cells requires interactions with class I MHC determinants. Nature 333:180–183, 1988
    PubMed Google Scholar
  38. Crabtree GR: Contingent genetic regulatory events in T lymphocyte activation. Science 243:355–361, 1989
    PubMed Google Scholar

Download references