A marked rise in 5-S-cysteinyl-dopamine levels in guinea-pig striatum following reserpine treatment (original) (raw)

Summary

Reserpine administration (5 mg/kg, i.p.) to guinea pigs resulted in marked and long lasting dopamine (DA) depletion and a rapid, short lasting, increase of 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum. A marked and sustained increase of the level of 5-S-cysteinyl-dopamine, which is an adduct presumably formed following autoxidation of DA, started 3–4 h following the DA and DOPAC changes. Only small changes in the levels of the 5-S-cysteinyl adducts of DOPAC and 3,4-dihydroxyphenylalanine (DOPA) were found.

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1. B. Fornstedt
   Present address: Department of Pharmacology, University of Göteborg, Göteborg, Sweden

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1. Department of Pharmacology, University of Göteborg, Göteborg, Sweden
   A. Carlsson

Authors

1. B. Fornstedt
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2. A. Carlsson
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Fornstedt, B., Carlsson, A. A marked rise in 5-S-cysteinyl-dopamine levels in guinea-pig striatum following reserpine treatment.J. Neural Transmission 76, 155–161 (1989). https://doi.org/10.1007/BF01578755

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• Received: 12 January 1989
• Accepted: 13 January 1989
• Issue Date: June 1989
• DOI: https://doi.org/10.1007/BF01578755

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