Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation (original) (raw)

References

  1. Mohler, H., Benke, D., Rhyner, T., and Sigel, E. 1992. Molecular pharmacology of GABAA receptors, pages 87–100,in Schousboe, A., Diemer, N. H., and Kofod, H. (eds.), Drug research related to neuroactive amino acids, Alfred Benzon Symposium, Munksgaard, Copenhagen.
    Google Scholar
  2. Macdonald, R. L., and Olsen, R. W. 1994. GABAA receptor channels. Annu. Rev. Neurosci. 17:569–602.
    PubMed Google Scholar
  3. Nayeem, N., Green, T. P., Martin, I. L., and Barnard, E. A. 1994. Quaternary structure of the native GABAA receptor determined by electron microscopic image analysis. J. Neurochem. 62:815–818.
    PubMed Google Scholar
  4. Benke, D., Mertens, S., Trzeciak, A., Gillessen, D., and Mohler, H. 1991. GABAA receptors display association of γ2-subunit with α1- and β2/3 subunits. J. Biol. Chem. 266:4478–4483.
    PubMed Google Scholar
  5. Fritschy, J. M., Benke, D., Mertens, S., Oertel, W. H., Bachi, T., and Mohler, H. 1992. Five subtypes of type A γ-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies. Proc. Natl. Acad. Sci. USA 89:6726–6730.
    PubMed Google Scholar
  6. Mertens, S., Benke, D., and Mohler, H. 1993. GABAA receptor populations with novel subunit combinations and drug binding profiles identified in brain by α5- and δ-subunit-specific immunopurification. J. Biol. Chem. 268:5965–5973.
    PubMed Google Scholar
  7. Benke, D., Fritschy, J. M., Trzeciak, A., Bannwarth, W., and Mohler, H. 1994. Distribution, prevalence and drug-binding profile of GABAA-receptors subtypes differing in β-subunit isoform. J. Biol. Chem. 269:27100–27107.
    PubMed Google Scholar
  8. Duggan, M. J., and Stephenson, F. A. 1990. Biochemical evidence for the existence of γ-aminobutyrateA receptor iso-oligomers. J. Biol. Chem. 265:3831–3835.
    PubMed Google Scholar
  9. McKernan, R. M., Quirk, K., Prince, R., Cox, P. A., Gillard, N. P., Ragan, C. I., and Whiting, P. 1991. GABAA receptor subtypes immunopurified from rat brain with α subunit-specific antibodies have unique pharmacological properties. Neuron 7:667–676.
    PubMed Google Scholar
  10. Ruano, D., Araujo, F., Machado, A., Deblas, A. L., and Vitorica, J. 1994. Molecular characterization of type I GABA(A) receptor complex from rat cerebral cortex and hippocampus. Mol. Brain. Res. 25:225–233.
    PubMed Google Scholar
  11. Benke, D., Mertens, S., and Mohler, H. 1991. Ubiquitous presence of GABAA receptors containing the α1-subunit in rat brain demonstrated by immunoprecipitation and immunohistochemistry. Mol. Neuropharmacol. 1:103–110.
    Google Scholar
  12. Marksitzer, R., Benke, D., Fritschy, J. M., and Mohler, H. 1993. GABAA-receptors: Drug binding profile and distribution of receptors containing the α2-subunit in situ. J. Recept. Res. 13:467–477.
    PubMed Google Scholar
  13. Gao, B., Fritschy, J. M., Benke, D., and Mohler, H. 1993. Neuron-specific expression of GABAA-receptor subtypes: differential associations of the α1- and α3-subunits with serotonergic and GABAergic neurons. Neurosci. 54:881–892.
    Google Scholar
  14. Gao, B., Hornung, J. P., and Fritschy, J. M. 1995. Identification of distinct GABAA-receptor subtypes in cholinergic and parvalbumin-positive neurons of the rat and marmoset medial-septum. Neurosci., in press.
  15. Schofield, P. R., Darlison, M. G., Fujita, N., Burt, D. R., Stephenson, F. A., Rodriguez, H., Rhee, L. M., Ramachandran, J., Reale, V., Glencorse, T. A., Seeburg, P. H., and Barnard, E. A. 1987. Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family. Nature 328:221–227.
    PubMed Google Scholar
  16. Malherbe, P., Draguhn, A., Multhaup, G., Beyreuther, K., and Mohler, H. 1990. GABAA-receptor expressed from rat brain α-and β-subunit cDNAs displays potentiation by benzodiazepine receptor ligands. Mol. Brain. Res. 8:199–208.
    PubMed Google Scholar
  17. Sigel, E., Baur, R., Trube, G., Mohler, H., and Malherbe, P. 1990. The effect of subunit composition of rat brain GABAA receptors on channel function. Neuron 5:703–711.
    PubMed Google Scholar
  18. Pritchett, D. B., Sontheimer, H., Shivers, B. D., Ymer, S., Kettenmann, H., Schofield, P. R., and Seeburg, P. H. 1989. Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology. Nature 338:582–585.
    PubMed Google Scholar
  19. Angelotti, T., and Macdonald, R. L. 1993. Assembly of GABAA receptor subunits: α1β1 and α1β1γ2s subunits produce unique ion channels with dissimilar single-channel properties. J. Neurosci. 13:1429–1440.
    PubMed Google Scholar
  20. Pritchett, D. B., Luddens, H., and Seeburg, P. H. 1989. Type I and type II GaBAA-benzodiazepine receptors produced in transfected cells. Science 245:1389–1392.
    PubMed Google Scholar
  21. Pritchett, D. B., and Seeburg, P. H. 1990. γ-aminobutyric acidA receptor α5-subunit creates novel type II benzodiazepine receptor pharmacology. J. Neurochem. 54:1802–1804.
    PubMed Google Scholar
  22. Wisden, W., Herb, A., Wieland, H., Keinanen, K., Luddens, H., and Seeburg, P. H. 1991. Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor α4 subunit. FEBS Lett. 289:227–230.
    PubMed Google Scholar
  23. Luddens, H., Pritchett, D. B., Kohler, M., Killisch, I., Keinanen, L., Monyer, H., Sprengel, R., and Seeburg, P. H. 1990. Cerebellar GABAA-receptor selective for a behavioral alcohol antagonist. Nature 346:648–651.
    PubMed Google Scholar
  24. Wieland, H. A., Luddens, H., and Seeburg, P. H. 1992. A single histidine in GABAA receptors is essential for benzodiazepine agonist binding. J. Biol. Chem. 267:1426–1429.
    PubMed Google Scholar
  25. Haefely, W., Martin, J. R., and Schoch, P. 1990. Novel anxiolytics that act as partial agonists at benzodiazepine receptors. Trends Pharmacol. Sci. 11:452–456.
    PubMed Google Scholar
  26. Puia, G., Dudic, I., Vicini, S., and Costa, E. 1992. Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at γ-aminobutyric acid type A receptor. Proc. Natl. Acad. Sci. USA 89:3620–3624.
    PubMed Google Scholar
  27. Wafford, K. A., Whiting, P. J., and Kemp, J. A. 1993. Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant γ-aminobutyric acid receptor subtypes. Mol. Pharmacol. 43:240–244.
    PubMed Google Scholar
  28. Knoflach, F., Drescher, U., Scheurer, L., Malherbe, P., and Mohler, H. 1993. Full and partial agonism displayed by benzodiazepine receptor ligands at different recombinant GABAA receptor subtypes. J. Pharmacol. Exp. Ther. 266:385–391.
    PubMed Google Scholar
  29. Pribilla, I., Neuhaus, R., Huba, R., Hillmann, M., Turner, J. D., Stephens, D. N., and Schneider, H. H. 1993. Abercanil is a full agonist a some, and a partial agonist at other recombinant GABAA receptor subtypes, pages 50–61, in Stephens, D. N. (ed.), Anxiolytic β-carbolines, Springer-Verlag, Berlin.
    Google Scholar
  30. Paysan, J., Kossel, A., Thanos, R., Fritschy, J. M., Mohler, H., and Bolz, J. 1993. Area-specific regulation of the GABAA-receptor α1-subunit in developing rat neocortex deprived of afferent innervation. Soc. Neurosci. Abstracts 19:1107.
    Google Scholar
  31. Fritschy, J. M., Paysan, J., Enna, A., and Mohler, H. 1994. Switch in the expression of rat GABAA-receptor subtypes during postnatal development: an immunohistochemical study. J. Neurosci. 14: 5302–5324.
    PubMed Google Scholar
  32. Paysan, J., Bolz, J., Mohler, H., and Fritschy, J. M. 1994. The GABAA-receptor α1-subunit: an early marker of cortical parcellation. J. Comp. Neurol. 350:133–149.
    PubMed Google Scholar
  33. Paysan, J., Mohler, H., and Fritschy, J. M. 1994. Switch in the expression of GABAA-receptor subtypes during postnatal development. Eur. J. Neurosci. Suppl. 7:81.
    Google Scholar
  34. Hendry, S. H. C., Huntsman, M. M., Vinuela, A., Mohler, H., de Blas, A. L., and Jones, E. G. 1994. GABAA receptor subunit immunoreactivity in primate visual cortex: distribution in macaques and humans and regulation by visual input in adulthood. J. Neurosci. 14:2383–2401.
    PubMed Google Scholar
  35. Huntsman, M. M., Isackson, P. J., and Jones, E. G. 1994. Lamina-specific expression and activity-dependent regulation of seven GABAA receptor subunit mRNAs in monkey visual cortex. J. Neurosci. 14:2236–2259.
    PubMed Google Scholar
  36. Motejlek, K., Hauselmann, R., Leitgeb, S., and Luscher, B. 1994. BSF1, a novel brain-specific DNA-binding protein recognizing a tandemly repeated purine DNA element in the GABAA receptor δ subunit gene. J. Biol. Chem. 269:15265–15273.
    PubMed Google Scholar
  37. Savic, I., Roland, P., Sedvall, G., Persson, A., Pauli, S., and Widen, L. 1988. In-vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci. Lancet 2:863–866.
    PubMed Google Scholar
  38. McDonald, J. W., Garofalo, E. A., Hood, T., Sackellares, J. C., Gilman, S., McKeever, P. E., Troncoso, J. C., and Johnston, M. V. 1991. Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy. Ann. Neurol. 29:529–541.
    PubMed Google Scholar
  39. Faull, R. L. M., Waldvogel, H. J., Nicholson, L. F. B., and Synek, B. J. L. 1993. The distribution of GABAA-benzodiazepine receptors in the basal ganglia in Huntington's disease and in the quinolinic acid-lesioned rat, pages 105–123, in Arbuthnott, G. W. and Emson, P. C. (eds.), Progress in Brain Research, Chemical signalling in the basal ganglia, Vol. 99, Elsevier, Amsterdam.
    Google Scholar
  40. Kokaia, M., Pratt, G. D., Elmer, E., Bengzon, J., Fritschy, J. M., Lindvall, O., and Mohler, H. 1994. Biphasic differential changes of GABAA-receptor subunit mRNA levels in dentate gyrus granule cells following recurrent kindling induced seizures. Mol. Brain. Res. 23:323–332.
    PubMed Google Scholar

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