Malassezia furfur-related colonization and infection of central venous catheters (original) (raw)

Abstract

Objective

To determine the incidence of_Malassezia furfur_-related colonization and infection of central venous catheters.

Design

Prospective clinical study.

Setting

A paediatric intensive care unit at a University Hospital.

Patients

66 newborns with central venous catheters for parenteral nutrition including lipid emulsions (Intralipid®).

Methods

When a central venous catheter was removed, it was rinsed with 1 ml of physiological saline, transported at ambient temperature to the clinical laboratory and cultured on Dixon's medium. The tip of the central venous catheter was used for a bacteriological study using Maki's technique. In case of suspected sepsis, blood cultures were obtained using an Isolator® tube.

Results

74 central venous catheters were included: mean duration of use of a central venous catheters and infusions of lipid emulsion (Intralipid®) were 19.3±10 days and 8.6±8 days respectively. Only 2 central venous catheters (2.7%) were colonized by_Malassezia furfur_: (Mf) one in an asymptomatic newborn, and the other in an infected newborn with signs of sepsis, who most probably died at 4 months of age from refractory hypoxia due to pulmonary hypoplasia, but not from Mf sepsis.

Conclusions

The incidence of_Malassezia furfur_-related colonization of central venous catheters appears to be low but not negligible, which warrants the use of specific culture techniques.

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Authors and Affiliations

  1. Pediatric Intensive Care and Neonatology Department, Centre Hospitalier Universitaire, F-29609, Brest Cedex, France
    J. Sizun, A. Karangwa, J. D. Giroux, D. Alix & L. De Parscau
  2. Mycology Laboratory, Centre Hospitalier Universitaire, F-29609, Brest Cedex, France
    O. Masure & A. M. Simitzis

Authors

  1. J. Sizun
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  2. A. Karangwa
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  3. J. D. Giroux
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  4. O. Masure
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  5. A. M. Simitzis
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  6. D. Alix
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  7. L. De Parscau
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Additional information

This study was partially supported by a clinical research pilot study grant from INSERM France (91CN52)

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Sizun, J., Karangwa, A., Giroux, J.D. et al. _Malassezia furfur_-related colonization and infection of central venous catheters.Intensive Care Med 20, 496–499 (1994). https://doi.org/10.1007/BF01711902

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