Eliakim R, Rachmilewitz D: Potential mediators in inflammatory bowel disease. Gastroenterol Int 5:48–56, 1992 Google Scholar
Mannaioni PF, Masini E, Pistelli A, Salvemini D, Vane JR: Mast cells as a source of superoxide anions and nitric oxide-like factor: Relevance to histamine release. Int J Tissue Reac 13:271–278, 1991 Google Scholar
Kanwar S, Wallace JL, Befus D, Kubes P: Nitric oxide modulates mucosal barrier function: A potential role of mast cells. Gastroenterology 105:A249, 1993 Google Scholar
Oates PJ, Hakkinen JP: Studies on the mechanism of ethanol induced gastric damage in rats. Gastroenterology 94:10–21, 1988 PubMed Google Scholar
Rioux KP, Wallace JL: Activation of mucosal mast cells augments gastric mucosal injury. Gastroenterology 105:A401, 1993 Google Scholar
Stead RH, Tomioka M, Riddell RH, Bienenstock J: Substance P and/or calcitonin gene related peptide are present in subepithelial enteric nerves apposed to intestinal mucosal mast cells.In: Inflammatory Bowel Disease: Current Status and Future Approach. RP MacDermott (ed). Amsterdam, Elsevier Scientific Publications, 1988, pp 43–48 Google Scholar
Whittle BJR, Lopez-Belmonte J: Gastric mucosal damage and protection: Involvement of novel endothelium-derived mediators. In: The Stomach, Physiology, Pathophysiology and Treatment. W Domschke, SJ Konturek (eds). Berlin, Springer-Verlag, 1993, pp 68–82 Google Scholar
Lambrecht N, Butchert H, Responde KM, Muller K-M, Peskar BM: Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin. Gastroenterology 104:1371–1380, 1993 PubMed Google Scholar
Wang L, Stanisz AM, Perdue MH: Activation of mast cells by substance P in the regulation of ion secretion in mouse small intestine. Gastroenterology 104:A156, 1993 Google Scholar
Wallace JL, McKnight GW, Befus D: Capsaicin induced hyperemia in the stomach: Possible contribution of mast cells. Am J Physiol 263:G209-G214, 1992 PubMed Google Scholar
Crowe SE, Perdue MH: Gastrointestinal food hypersensitivity: Basic mechanisms of pathophysiology. Gastroenterology 103:1075–1095, 1992 PubMed Google Scholar
Eliakim R, Karmeli F, Okon E, Rachmilewitz D: Ketotifen effectively prevents mucosal damage in experimental colitis. Gut 33:1498–1503, 1992 PubMed Google Scholar
Pothoulakis C, Karmeli F, Kelly CP, Eliakim R, Joshi MA, O'Keane CJ, Castaglivolo I, LaMont JT, Rachmilewitz D: Ketotifen inhibits clostridium difficile toxin A-induced enteritis in rat ileum. Gastroenterology 105:701–707, 1993 PubMed Google Scholar
Szolcanyi J, Bartho L: Impaired defense mechanism to peptic ulcer in the capsaicin desensitized rat. In: Advanced Physiological Sciences, Vol 15, Gastrointestinal Defense Mechanisms. GY Mozsic, O Hanninen, T Javor (eds). Oxford, Pergamon Press, 1981, pp 39–51 Google Scholar
Martling CR: Sensory nerves containing tachykinins and cGRP in the lower airways. Acta Physiol Scand 563(suppl):1–57, 1987 Google Scholar
Rachmilewitz D, Stamler JS, Karmeli F, Mullins ME, Singel DJ, Loscalzo J, Xavier RJ, Podolsky DK: Peroxynitrite-induced rat colitis—a new model of colonic inflammation. Gastroenterology 105:1681–1688, 1993 PubMed Google Scholar
Bush PA, Gonzalez NE, Griscavage JM, Ignarro LJ: Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline froml-arginine. Biochem Biophys Res Commun 185:960–966, 1992 PubMed Google Scholar
Sharkey KA, Williams RG, Dockray GJ: Sensory substance P innervation of the stomach and pancreas. Demonstration of capsaicin-sensitive sensory neurons in the rat by combined immunohistochemistry and retrograde tracing. Gastroenterology 87:914–921, 1984 PubMed Google Scholar
Leung FN: Role of capsaicin-sensitive afferent nerves in mucosal injury and injury-induced hyperemia in rat colon. Am J Physiol 262:G332–337, 1992 PubMed Google Scholar
Domek MJ, Blackman E, Vidrich A, Kao J, Baker M, Leung FW: Capsaicin pretreatment increases severity of dextran sulfate sodium (DSS)-induced colonic damage in rats. Gastroenterology 105:A615, 1993 Google Scholar
Reinshagen M, Patel A, Sottili M, Procaccino F, French S, Eysslein VE: Effect of sensory neurons in chronic colitis. Gastroenterology 105:A173, 1993 Google Scholar
Barret KE: Involvement of histamine in a rat model of inflammatory bowel disease. Gastroenterology 98:A653, 1990 Google Scholar
Rachmilewitz D, Stamler JS, Bachwich D, Karmeli F, Ackerman Z, Loscalzo J, Podolsky DK: Enhanced colonic NO generation and stimulated NO synthase activity in experimental colitis and in active inflammatory bowel disease. Gastroenterology 105:A236, 1993 Google Scholar
Boughton-Smith NK, Evans SM, Cole AT, Hawkey CJ, Whittle BJR, Moncada S: Induction of nitric oxide synthase in inflamed colon from ulcerative colitis patients. Gastroenterology 105:A236, 1993 Google Scholar
Mourelle M, Videla S, Vilaseca J, Guarner F, Malagelada JR: Induction of nitric oxide synthase in the course of toxic megacolon in a rat model of colitis. Gastroenterology 105:A237, 1993 Google Scholar
Miller HJS, Sadowska-Krowicka A, Chotinaruemol S, Kakkis JL, Clark DA: Amelioration of chronic ileitis by nitric oxide synthase inhibition. J Pharmacol Exp Ther 264:11–16, 1993 PubMed Google Scholar
Stenson WF, Lauristen K, Laursen LS, Rask-Madsen J, Jacobsen O, Naesdal J, Cort D, Goebell H, Peskar B, Hanaver S, Swanson L, Dube L, Rubin P: A clinical trial of Zileuton, a specific inhibitor of 5-lipoxygenase in ulcerative colitis. Gastroenterology 100:A253, 1991. Google Scholar
Sharon P, Stenson WF: Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease. Gastroenterology 86:453–460, 1984 PubMed Google Scholar
Wallace JL, MacNaughton WK, Morris GP, Beck PL: Inhibition of leukotriene synthesis markedly accelerated healing in a rat model of inflammatory bowel disease. Gastroenterology 96:29–36, 1989 PubMed Google Scholar
Fretland DJ, Levin S, Tsai BS, Djuric SW, Widomski DL, Zemaitis JM, Shone RL, Bauer RF: The effect of leukotriene B4 receptor antagonist, SC-41930, on acetic acid induced colonic inflammation. Agents Actions 27:395–397, 1989 PubMed Google Scholar