Increased serum soluble interleukin-2 receptors in schizophrenic monozygotic twins (original) (raw)
Summary
There is a confusing history of immune findings associated with schizophrenia. At least some of these discrepant results may be artifacts caused by heterogeneity. In an attempt to decrease heterogeneity, we studied three groups of monozygotic twins who were either discordant for schizophrenia, concordant and ill, or concordant and well. This comparison minimizes environmental and genetic variance, and heightens differences that are actually due to the disorder. Overall, schizophrenic subjects had higher levels of serum soluble interleukin-2 receptors (SIL-2Rs) than unaffected individuals (480.8, SD 238.6 U/ml vs 380.9, SD 170.6 U/ml;_F_=5.256,_df_=1.61,_P_=0.02). When data from discordant and concordant twin groups were analysed separately, both the discordant ill twins (_P_=0.06) and concordant ill twin pairs (_P_=0.08) showed trends towards higher serum SIL-2R levels than their respective control groups. These data contribute to the growing body of evidence that immune activation is associated with some forms of schizophrenia.
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Authors and Affiliations
- Department of Psychiatry, University of California, San Diego School of Medicine, 9500 Gilman Drive, 92093, La Jolla, California, USA
Mark Hyman Rapaport, E. Fuller Torrey, Cathy G. McAllister, David L. Nelson, David Pickar & Steven M. Paul - Psychiatric Service of the San Diego Veterans Affairs Medical Center, San Diego, USA
Mark Hyman Rapaport, E. Fuller Torrey, Cathy G. McAllister, David L. Nelson, David Pickar & Steven M. Paul - The Clinical Brain Disorders Branch of the Intramural Research Program, National Institute of Mental Health, St. Elisabeth Hospital, Washington DC, USA
Mark Hyman Rapaport, E. Fuller Torrey, Cathy G. McAllister, David L. Nelson, David Pickar & Steven M. Paul - The Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA
Mark Hyman Rapaport, E. Fuller Torrey, Cathy G. McAllister, David L. Nelson, David Pickar & Steven M. Paul - The Clinical Therapeutics Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Mark Hyman Rapaport, E. Fuller Torrey, Cathy G. McAllister, David L. Nelson, David Pickar & Steven M. Paul - The Division of Intramural Research, National Institute of Mental Health, Bethesda, Maryland, USA
Mark Hyman Rapaport, E. Fuller Torrey, Cathy G. McAllister, David L. Nelson, David Pickar & Steven M. Paul
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- Mark Hyman Rapaport
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The Metabolism Branch of the National Cancer Institute
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Rapaport, M.H., Torrey, E.F., McAllister, C.G. et al. Increased serum soluble interleukin-2 receptors in schizophrenic monozygotic twins.Eur Arch Psychiatry Clin Nuerosci 243, 7–10 (1993). https://doi.org/10.1007/BF02191517
- Received: 31 December 1992
- Issue Date: July 1993
- DOI: https://doi.org/10.1007/BF02191517