Competition for sucrose-pellets in triads of male wistar rats: effects of acute and subchronic chloridazepoxide (original) (raw)
Abstract
Within triads of male Wistar rats, some animals almost completely abstain from competition for palatable sucrose pellets (so-called poor-performing rats), whereas other rats consistently win the competition (so-called high-performing rats). Subchronic (5 mg/kg; 5 consecutive days), but not acute (0.1–20 mg/kg), treatment with chlordiazepoxide temporarily helped poor-performing rats to behave more competitively. This finding, considered together with parallel studies (using high-performing rats), suggested that chloridazepoxide's beneficial effect was only demonstrable when the poor-performing rats had become tolerant to the drug's initial sedative effect.
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References
- Blanchard RJ, Blanchard DC, Takahashi T, Kelley MJ (1977) Attack and defensive behavior in the Albino rat. Anim Behav 25:622–634
Google Scholar - Cooper SJ, Benzodiazepines as appetite-enhancing compounds. Appetite 1:7–19
- Dixon WJ, Mood AM (1966) The statistical sign test. J Am Statist Assoc 41:557–566
Google Scholar - File SE, Hyde JRG (1978) Can social interaction be used to measure anxiety? Br J Pharmacol 62:19–24
Google Scholar - File SE (1986) Effects of chloridazepoxide on competition for a preferred food in the rat. Behav Brain Res 21:195–202
Google Scholar - File SE (1988) How good is social interaction as a test for anxiety? In: Simon P, Soubrie P, and Wildlocher D (eds) Animal models of psychiatric disorders, vol 1. Karger, Basel, pp 151–166
Google Scholar - Gentsch C, Lichtsteiner M, Feer H (1987) Open field and elevated plus-maze: a behavioural comparison between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats and the effects of chloridazepoxide. Behav Brain Res 25:101–107
Google Scholar - Gentsch C, Lichtsteiner M, Feer H (1988a) Competition for sucrose-pellets in trials of male Wistar rats: the individuals performances are differing but stable. Behav Brain Res 27:37–44
Google Scholar - Gentsch C, Lichtsteiner M, Feer H (1988b) Competition for sucrose-pellets in triads of male Wistar rats: effects of three serotonergic drugs. Prog Neuropsychopharmacol Biol Psychiatry 12:639–651
Google Scholar - Gentsch C, Lichsteiner M, Feer H (1988c) Competition for sucrose-pellets in triads of rats: idazoxan improves the poor-performing rats' competition-rate. Psychopharmacology 96:S22
Google Scholar - Gray J (1982) The neuropsychology of anxiety: an enquiry into the function of the septo-hippocampal system. Oxford University Press, Oxford, pp 3–548
Google Scholar - Haefely W, Pieri L, Polc P, Schaffner R (1981) General pharmacology and neuropharmacology of benzodiazepine derivatives. In: Hoffmeister F, Stille G (eds) Handbook of experimental pharmacology, vol 55. Springer, Berlin Heidelberg New York, pp 13–262
Google Scholar - Jaekel J (1976) Wirkung von Psychopharmaka auf soziales und individuelles Verhalten von Tieren. Fortschritte der Veterinär-medizin 25:61–65
Google Scholar - Kostowski W, Plewako W, Bidzinski A (1984) Brain serotonergic neurons: Their role in a form of dominance-subordination in rats. Physiol Behav 33:365–371
Google Scholar - Militzer K, Reinhard HJ, Wecker E (1984) Sozialer Rang, Sexualität und ihre Beziehungen zu morphologischen und biochemischen Befunden bei männlichen DA-Ratten. Z Versuchstierk 26:217–230
Google Scholar - Mitchell JA, Lewis RM, Wilson MC (1989) The effects of d-amphetamine on food competition in male rats. Pharmacol Biochem Behav 27:707–714
Google Scholar - Mos J, Olivier B (1988) Differential effects of selected psychoactive drugs on dominant and subordinate male rats housed in a colony. Neurosci Res Commun 2:29–36
Google Scholar - Olivier B, Mos J (1986) Serenics and aggression. Stress Medicine 2:197–209
Google Scholar - Plewako M, Kostowski W (1984) The effects of lesions of the locus coeruleus and treatment with drugs affecting brain noradrenergic neurotransmission on dominant-subordinate behavior in rats competing for water. Pol J Pharmacol Pharm 36:555–560
Google Scholar - Pratt J, Jenner P, Marsden CD (1985) Comparison of the effect of benzodiazepines and other anticonvulsant drugs on synthesis and utilization of 5-HT in mouse brain. Neuropharmacology 24:59–68
Google Scholar - Saner A, Pletscher A (1979) Effects of diazepam on cerebral 5-hydroxytryptamine synthesis. Eur J Pharmacol 55:315–318
Google Scholar - Soubrie P, Blas C, Ferron A, Glowinski J (1983) Chlordiazepoxide reduces in vivo serotonin release in the basal ganglia of ‘encephale isol’ but not of anesthetized cats: evidence for a dorsal raphe site of action. J Pharmacol Exp Ther 226:526–532
Google Scholar - Traber J, Glaser T (1987) 5-HT1A receptor-related anxiolytics. TIPS 8:432–437
Google Scholar - Trulson ME, Preussler DW, Howell GA, Frederickson CJ (1982) Raphe unit activity in freely moving cats: effects of benzodiazepines. Neuropharmacology 21:1050–1082
Google Scholar
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- Psychiatric University Clinic Basle, Biochemical Laboratory, Wilhelm Kleinstrasse 27, CH-4025, Basle, Switzerland
C. Gentsch, M. Lichtsteiner & H. Feer
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- C. Gentsch
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Gentsch, C., Lichtsteiner, M. & Feer, H. Competition for sucrose-pellets in triads of male wistar rats: effects of acute and subchronic chloridazepoxide.Psychopharmacology 100, 530–534 (1990). https://doi.org/10.1007/BF02244007
- Received: 06 July 1989
- Revised: 10 November 1989
- Issue Date: April 1990
- DOI: https://doi.org/10.1007/BF02244007